A Critical Review on Health Promoting Benefits of Sana Makki (Senna Alexendrina)

Main Article Content

Muhammad Abbas Khan, Arshad Mehmood Malik, Sehrish khan, Nigah Hussain, Maria Fayyaz, Sajid Hussain

Keywords

Senna Alexendrina, History, Phytochemistry, Beneficial Impact on human health.

Abstract

A plant with a long history of therapeutic usage is senna alexandrina, occasionally referred to to be senna or Alexandrian senna. This paper thoroughly examines Senna alexandrina's many pharmacological traits and therapeutic uses, emphasizing its relevance in both conventional and contemporary medicine. The plant is a crucial component in many herbal laxatives due to its active components, especially anthraquinone glycosides, which have strong laxative effects. Recent study has shown its potential to manage a variety of health issues in addition to its well-established usefulness in relieving constipation. Currently with the discovery of modern drugs and their significance, natural products-based drugs are also looked for their potency in treating various microbial and other infections. Senna alexandrina is an evergreen shrub grown throughout the year. It has antimicrobial and anti-inflammatory properties. It is commercially grown in Pakistan, India, Sudan, and Egypt. It has been used in Indian conventional-medicine for its good pharmacological effects. The objectives of current review are to discuss the chemical components, uses and potential effects on human health of senna plant. This paper provides a thorough examination of Senna alexandrina's medical significance, highlighting the plant's numerous therapeutic uses. Understanding the scientific underpinnings of the plant's conventional application is essential for optimizing its advantages and reducing any possible hazards as interest in natural medicines rises.

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References

Abdallh, S. S. A. (2019). Determination of Concentration of Elements in Senna Alexadrina by X-Ray Fluorescence (Doctoral dissertation, Sudan University of Science and Technology).
Ahmad, M., Khan, M.A., Zafar, M., Arshad, M., Sultana, S. and Abbasi, B.H., 2010. Use of chemotaxonomic markers for misidentified medicinal plants used in traditional medicines. Journal of Medicinal Plants Research, 4(13), pp.1244-1252.
Ahmed, M. (2015). Some medicinal plant resources and traditional uses in Pakistan. Journal of Plant Breeding and Crop Science, 7(5), 158-162.
Ahmed, S. I., Hayat, M. Q., Tahir, M., Mansoor, Q., Ismail, M., Keck, K., &and Bates, R. B. (2016). Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl. BMC complementary and alternative medicine, 16(1), 1-
Anonymous (2003) The Ayurvedic Pharmacopoeia of India (2nd ed.) New Delhi: Governament of India, Ministry of Health and Family Welfare, Department of AYUSH, Part 1, pp. 225.
BHAKSHU, L. M., & RAJU, R. V. (2023). Phytochemical and Pharmacological Appraisal of Cassia angustifolia Vahl.(Syn.: Senna alexandrina Mill.). Phytochemical Composition and Pharmacy of Medicinal Plants: 2-volume set, 35.
Balasankar, D., Vanilarasu, K., Preetha, P. S., Rajeswari, S., Umadevi, M., & Bhowmik, D. 2013). Senna–A medical miracle plant. Journal of medicinal plants studies, 1(3), 41-47.
Balasankar, D., Vanilarasu, K., Preetha, P. S., Umadevi, S. R. M., & Bhowmik, D. (2013). Journal of medicinal plants studies. Journal of Medicinal Plants, 1(3).
Balasankar, D., Vanilarasu, K., Preetha, P.S., Rajeswari, S., Umadevi, M. and Bhowmik, D., 2013. Senna–A medical miracle plant. Journal of medicinal plants studies, 1(3), pp.41-47.
Boaduo NKK, Katerere D, Eloff JN, Naidoo V (2014) Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in South Africa using in vitro methods. Pharmaceutical biology 52: 756–761. pmid:24559378.
Borrelli, F. and Izzo, AA. (2000): The Plant Kingdom as a Source of Anti-ulcer Remedies. Phytotherapy Research, 14(8):581–591.
Bruneton J (1995) Pharmacognosy, phytochemistry, medicinal plants. Lavoisier Publishing
Chaubey, M.; Khanna, M.; Mehrotra, S.; Singh, S.; Kapoor, V. P. Abstracts of Papers; 4th National Conference, Indian Society of Chemists and Biologists: Lucknow, India, January 2000, p. 23.
Delfan B, Bahmani M, Kazemeini H, Zargaran A, Rafieian-Kopaei M, et al. (2016) Identification of Effective Medicinal Plants for Hyperlipidemia: An Ethnobotanical Study in Lorestan Province, West of Iran. Traditional and Integrative Medicine: 28–34.
Duke JA. Handbook of Medicinal Herbs. 2nd ed. Boca Raton, FL: CRC Press, 2002.
Duke, J. A. (2008). Duke’s Handbook of Medicinal Plants of the Bible CRC press s. 237-240.
Dziedzic, S. Z., & Hudson, B. J. (1984). Phenolic acids and related compounds as antioxidants for edible oils. Food Chemistry, 14(1), 45-51.
European Commission (EC). (2019). EU Novel food catalogue.
Farag MA, Porzel A, Mahrous EA, Mo’men M, Wessjohann LA (2015) Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis. Analytical and bioanalytical chemistry 407: 1937–1949. pmid:25577360
Gerard Haiek and Stephen Tillett, 2010. El Jardín Medicinal de la Revista El Palo de arco, el Sen, el Yagrumo y la Zarzaparrilla. Revista Facultad de Farmacia .Vol. 73 . Nº 2 . 44-45.
Ghorbani A (2017) Mechanisms of antidiabetic effects of flavonoid rutin. Biomedicine & Pharmacotherapy 96: 305–312. pmid:29017142
Goraya, G. S., & Ved, D. K. (2017). Medicinal plants in India: an assessment of their demand and supply. National Medicinal Plants Board, Ministry of AYUSH, Government of India. New Delhi and Indian Council of Forestry Research & Education, Dehradun.
Grubben, G. J. H., & Denton, O. A. (2004). Plant resources of tropical Africa 2. Vegetables. Plant resources of tropical Africa 2. Vegetables.
Nimrouzi, M., & Zarshenas, M. M. (2019). Holistic approach to functional constipation: Perspective of traditional Persian medicine. Chinese journal of integrative medicine, 25(11), 867-872.
Naz, H., Nawaz, H., Hanif, M. A., Ayub, M. A., & Khatun, S. (2020). Indian Senna. In Medicinal Plants of South Asia (pp. 439-449). Elsevier.
Osman N, Jambi E, Aseri N (2017) Assessment of antidiabetic and antioxidant activities of Cassia angustifolia and Feoniculum vulgare in diabetic rats. International Journal of Pharmaceutical Research & Allied Sciences 6.
Osunga, S., Amuka, O., Machocho, A. K., & Getabu, A. ETHNOBOTANY OF SOME MEMBERS OF THE GENUS CASSIA (SENNA).
Parsaei, P., Bahmani, M., Naghdi, N., Asadi-Samani, M., & Rafieian-Kopaei, M. (2016). The most important medicinal plants effective on constipation by the ethnobotanical documents in Iran: A review. Der Pharmacia Lettre, 8(2), 188-19
Passmore, A.P., Wilson-Davies, K., Stoker, C. and Scott, M.E., 1993. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. British Medical Journal, 307(6907), pp.769-771.
Ramchander, J., & Middha, A. (2017). Recent advances on Senna as a laxative: A comprehensive review. J. Pharmacognosy Phytochemistry, 6(2), 349-353.
Sanghi, R., Bhatttacharya, B., & Singh, V. (2002). Cassia angustifolia seed gum as an effective natural coagulant for decolourisation of dye solutions. Green Chemistry, 4(3), 252-254
Săvulescu E, Georgescu MI, Popa V, Luchian V. Morphological and Anatomical Properties of the Senna Alexandrina Mill.(Cassia Angustifolia Vahl.); 2018. Sciendo. pp. 305–310.
Săvulescu, E., Georgescu, M. I., Popa, V., & Luchian, V. (2018). Morphological and Anatomical Properties of the Senna alexandrina Mill. (Cassia Angustifolia Vahl.). Sciendo, 305-310.
Singh R, Kaur N, Kishore L, Gupta GK (2013) Management of diabetic complications: a chemical constituents based approach. Journal of ethnopharmacology 150: 51–70. pmid:24041460
Singh, K., (1992). Senna in the puerperium. Pharmacology, 44: 23-25.
T. H. El-Morsy. (2013): “Antibiotic Properties of Leaf Extracts of Senna alexandrina (L)”. J Am Sci 9(1):288- 292]. (ISSN: 1545-1003.
TRADESTAT-Export Import Data Bank Version 7.1. Kolkata, India: Government of India, Ministry of Commerce & Industry; 2018. Available at: https://tradestat.commerce.gov.in/eidb/icomq.asp. Accessed August 2, 2021.
Tripathi, Y.C., (1999). Cassia angustifolia, a versatile medicinal crop. International Tree Crops Journal, 10(2), pp.121-129.
Wang, X., Wang, T., Pan, T., Huang, M., Ren, W., Xu, G, & Moneim, A. E. A. (2020). Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats. Environmental Science and Pollution Research, 27(6), 5981-5992.
Werner, C., & Merz, B. (2007). Assessment report on Cassia senna L.
Werner, C., & Merz, B. (2007). Assessment report on Cassia senna L. and Cassia angustifolia Vahl, folium. European Medicines Agency, London, 1-32.
Wu QP, Wang ZJ, Fu MH, Tang LY, He Y, Fang J, Gong QF (2007) Chemical constituents from the leaves of Cassia angustifolia. Zhong Yao Cai 30:1250–1252.