SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES
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Keywords
Synthesis, Quinolines, Anti-bacterial and anti-fungal activities
Abstract
In the present study some novel Quinoline derivatives (1 to 11) have been synthesized by the reaction of 7-hydroxy 4-methyl Coumarin and Benzene Sulphonamide derivatives which are formed from starting materials Resorcinol, Ethyl Acetoacetate and Sulphanilamide compounds. The synthesized compounds were evaluated and characterized by TLC, melting point and spectral methods. All synthesized Quinoline derivatives were screened for Anti-bacterial activity and Antifungal activity. Some of the synthesized compounds showed good and moderate Anti-microbial activity.
References
2. Singh V, Singh J, Kumar K, Kad G. Acceleration of the Pechmann Reaction by Microwave Irradiation: Application to the Preparation of Coumarins. J of Chem. Research,1997; S:58–59.
3. Dinakaran V, Unnissa H, Kalishwari E. Synthesis and antibacterial activity of some 2,3- disubstituted quinoline-4(3H) ones. Indian J of Het chem.,2008;347-350.
4. Radha I H, Radi M. Synthesis of novel 2-quinolone derivatives. African J of Pure and Applied Chem,2010;4(10):228-32.
5. Hashem S, Monna H, Sakinesh E. A novel method for the synthesis of N- sulfonyl aldimines using AlCl3 under solvent-free conditions (SFC). ARKIVOC, 2007 (XV): 255- 64.
6. Dharmchand P, Deivedi S, Syed R, Singhal R. Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives. Pharmaceuticals, 2010;3:2416-25
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Gudivada Sridevi
Assistant Professor Department of Pharmaceutical Chemistry Victoria College of Pharmacy
Dr. Mohammad Mansoor
Professor and HOD Department of Pharmacology Victoria College of Pharmacy Email:
Chowpati Ramya
Victoria College of Pharmacy, Nallapadu, Guntur-522005, Andhra Pradesh, India.
Vangipurapu Nagalakshmi
Victoria College of Pharmacy, Nallapadu, Guntur-522005, Andhra Pradesh, India.