SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES

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Gudivada Sridevi
Dr. Mohammad Mansoor
Chowpati Ramya
Vangipurapu Nagalakshmi

Keywords

Synthesis, Quinolines, Anti-bacterial and anti-fungal activities

Abstract

In the present study some novel Quinoline derivatives (1 to 11) have been synthesized by the reaction of 7-hydroxy 4-methyl Coumarin and Benzene Sulphonamide derivatives which are formed from starting materials Resorcinol, Ethyl Acetoacetate and Sulphanilamide compounds. The synthesized compounds were evaluated and characterized by TLC, melting point and spectral methods. All synthesized Quinoline derivatives were screened for Anti-bacterial activity and Antifungal activity. Some of the synthesized compounds showed good and moderate Anti-microbial activity.

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