EVALUATION OF CITRUS PARADISE FOR CLINICAL EFFECT AND IMPLICATIONS IN WOMEN WITH DIABETES IN PREGNANCY
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Keywords
Citrus Paradise, Gestational diabetes mellitus, Metformin
Abstract
Objective: Feto-maternal outcomes and Glycemic control in Metformin versus citrus paradise treated Gestational Diabetics
Methodology: This cohort study was conducted from March 2019 to February 2022 at the Department of Obstetrics & Gynecology, Lyari General Hospital Karachi. Pregnant patients presenting in the antenatal clinic at 22-34 weeks of gestation with a singleton pregnancy were subjected to a 75gm oral glucose tolerance test (OGTT). Group 1 was started with Metformin at a dose of 500mg to a maximum dose of 2500mg daily. Group B was given 4 glasses (One glass equal to 250gram) of grapefruit juice daily for pharmacologic effects along with Metformin. Glycosylated hemoglobin (HbA1c), FBS and RBS were measured at the entry to the study and was repeated at each antenatal visit till 36 – 37 weeks of gestation. Maternal and perinatal outcomes were recorded on a predesigned proforma.
Results: In our study, most patients with primigravida 330(66%) and 380(76%) were Group A and B respectively. Fetal outcome mean 7.1±0.78 Apgar score was good in Group-B grapefruit with Metformin as compared with Group-A metformin 7.00±0.79. The mean Weight of the baby was 3±0.23 kg in group A, while 3.1±0.25 kg in group B. When maternal outcomes were tabulated there were significant differences between Group-A and B for HbA1C, FBS and RBS at term, significantly higher in Group-A.
Conclusion: There were lesser neonatal complications and better outcome observed in grapefruits along with metformin group as compared to metformin group in patients with gestational diabetes mellitus.
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Anjum Rehman
Professor of Gynae and Obs, Principal, Shaheed Mohtarma Benazir Bhutto Medical College, Lyari Karachi - Pakistan
Saher Fatima
Professor of Gynae and Obs, Professor, Shaheed Mohtarma Benazir Bhutto Medical College, Lyari Karachi - Pakistan
Zeeshan Ahmed
Senior Lecturer, United Medical and Dental College, Karachi - Pakistan
Ambreen Rehman
Chief Coordinator, Shaheed Mohtarma Benazir Bhutto Medical College, Lyari Karachi - Pakistan
Habiba Rehman
Director Research, Shaheed Mohtarma Benazir Bhutto Medical College, Lyari Karachi - Pakistan