Significance Of Dietary Factors In Occurrence, Prevention And Treatment Of Esophageal Carcinoma
Main Article Content
Keywords
esophageal cancer, nutritional supplement, dietary factors
Abstract
Esophageal cancer (EC) is a relatively rare cancer but highly fatal cancer due to delayed diagnosis and its malignant aggressive nature. Chemotherapy, radiotherapy, and esophagectomy are the main treatments for EC. However, recently, another complementary treatment has emerged in EC care: nutrition therapy.
Nutrition therapy utilizes diet and supplements to ensure that patients have enough nutrition to undergo treatment with minimal side-effects and long-term consequences by increasing treatment efficacy, vulnerability of EC cells, and reducing recurrence. The purpose of this study is to identify various EC-causing factors, pre- and post-operative circumstances & dietary habits that influence their development, along with the clinical steps that can be taken to improve EC care through nutrition therapy. We also emphasize the role of various nutritional components and supplements in EC prevention, cancer treatment efficacy, and rates of overall survival (OS) and recurrence.We found that several substances, including 5-fluorouracil, beta-carotene, and moringa, have anti-tumor properties, whereas vitamin C, and zinc also have the ability to boost the efficacy of treatment. Supplemental nutrition, such as glutamine, zinc, and omega-3 fatty acids, also decreased toxicity and stopped muscle deterioration after initial therapy.
On the other hand, we found that alcohol, smoking, red meat, excessive hot beverages, and self-diagnosing supplements like B12 can all lead to increased risk of developing EC. Hence, individualized nutrition can minimize side effects, preserve muscle mass, and avert malnutrition
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Abeer Asif, Shaifa Saleem, Ayesha Abdul Qadir Memon, Muhammad Mustafa, Arif Mahmood, Ghulam Rasool Bhurgri, Fahad Jibran Siyal, Muhammad Osama, & Calvin R. Wei. (2023). Significance Of Dietary Factors In Occurrence, Prevention And Treatment Of Esophageal Carcinoma. Journal of Population Therapeutics and Clinical Pharmacology, 30(1), 676–697. https://doi.org/10.53555/jptcp.v30i1.3103
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Author Biographies
Abeer Asif
KAM School of Life Science, Forman Christian College University (FCCU), Lahore, Pakistan
Shaifa Saleem
School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan
Ayesha Abdul Qadir Memon
Department of Pharmacy Practice, University of Karachi, Karachi, Pakistan
Muhammad Mustafa
KAM School of Life Science, Forman Christian College University (FCCU), Lahore, Pakistan
Arif Mahmood
Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China
Ghulam Rasool Bhurgri
Department of Pharmacology & Therapeutics, Indus Medical College, University of Modern Science, Tando Muhammad Khan, Sindh, Pakistan.
Fahad Jibran Siyal
Department of Pharmacology, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Sindh, Pakistan.
Muhammad Osama
Department of Pharmacology, University of Karachi, Karachi, Pakistan.
Calvin R. Wei
Department of Research and Development, Shing Huei Group, Taipei, Taiwan,