EFFECT OF ELEVATED URIC ACID IN FETOMATERNAL OUTCOME IN PREGNANCY INDUCED HYPERTENSION.
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Abstract
Pregnancy-induced hypertension (PIH) is a major concern in obstetrics, posing risks to both mothers and fetuses. Elevated serum uric acid levels have emerged as a potential indicator in PIH, yet their precise impact on maternal and fetal outcomes remains elusive. This study aimed to investigate the correlation between maternal serum uric acid levels and the outcomes experienced by both the mother and the newborn in cases of pregnancy-induced hypertension. In this cross-sectional study, 50 pregnant women in their second or third trimester diagnosed with pregnancy-induced hypertension (PIH) were included, aged between 18 and 40. Those with pre-existing conditions like chronic hypertension, chronic kidney disease, or diabetes were excluded. Data collection involved recording demographic and clinical information, including age, gestational age, parity, medical history, and blood pressure measurements using a mercury sphygmomanometer. Blood and urine samples were collected for uric acid and albumin level assessments. Diagnostic criteria for preeclampsia and its severity were applied, and fetomaternal outcomes, such as gestational diabetes, preterm birth, intrauterine growth restriction (IUGR), intrauterine death, low birth weight, and Apgar scores, were evaluated. The study found that uric acid levels were significantly associated with pregnancy induced hypertension (p=0.028) and IUGR (p=0.024). No significant correlations were observed between uric acid levels and the mode of delivery, prematurity, intrauterine death, or Apgar scores. However, infants born to mothers with uric acid levels >6 gm/dl were likelier to have low birth weight (p=0.04). Monitoring uric acid levels in PIH cases may serve as a valuable tool for risk assessment and intervention planning, potentially improving maternal and neonatal health outcomes. Further research is warranted to validate these associations and elucidate the underlying mechanisms
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Dr.Meghavini Parmar
Assistant professor, Department of Obstetrics and Gynaecology,GMERS Medical College, Himmatnagar
Dr.Shilpa Ninama
Assistant professor, Department of Obstetrics and Gynaecology, GMERS Medical College, Himmatnagar
Dr.Mayur Gandhi
Professor, Department of Obstetrics and Gynaecology, GMERS Medical College,Sola
Dr.Latika Mehta
Associate professor, Department of Obstetrics and Gynaecology, GMERS Medical College, Himmatnagar