ETHNO-PHARMACOLOGICAL INVESTIGATION OF SOME PLANTS FOR THE MANAGEMENT OF NEPHROTOXICITY
Main Article Content
Keywords
medicinal plant, phytochemicals, kidney disease, nephrotoxicity, nephroprotective.
Abstract
By 2040, kidney illnesses are anticipated to rank as the sixth greatest cause of mortality. Kidney injury is brought on by a number of physiological failures that are categorized as pre-, intra-, and post-renal causes. Pre-renal factors include things like diabetes, liver disorders, rhabdomyolysis, and intestinal microbiota, whereas post-renal causes include things like lithiasis, or blood clots in the ureters, prostate cancer, urethral blockages, prostate elongation, and urinary tract infections. Drug nephrotoxicity has also been identified as a significant contributor to kidney damage. Because certain medications have negative side effects, it is important to include additional therapy options for these disorders, such as nephroprotective agents. Plants are a rich source of nephroprotective compounds that can help at various stages of the physiological pathways that harm the kidneys. Plants are employed in traditional medicine for a variety of purposes, including as antioxidants, anti-inflammatories, diuretics, and anticancer agents. Scientific evidence is needed to substantiate some plants' nephroprotective properties because the mechanism of action of some of the plants that have been empirically employed is still unknown. The current study includes plants that reduce nephrotoxicity and phytochemicals that have nephroprotective effects
References
1. Smith HW. The kidney: structure and function in health and disease. Oxford University Press, USA; 1951
2. Deray G, Martinez F, Katlama C, Levaltier B, Beaufils H, Danis M, Rozenheim M, Baumelou A, Dohin E, Gentilini M, Jacobs C. Foscarnet nephrotoxicity: mechanism, incidence and prevention. American journal of nephrology. 1989 Oct 28;9(4):316-21.
3. Perazella MA. Renal vulnerability to drug toxicity. Clinical Journal of the American Society of Nephrology. 2009 Jul 1;4(7):1275-83.
4. Zhou Y, Vaidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, Miller TJ, Bonventre JV, Goering PL. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicological sciences. 2008 Jan 1;101(1):159-70.
5. Sabbahy ME, Vaidya VS. Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2011 Sep;3(5):606-18.
6. Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The clinical biochemist reviews. 2016 May;37(2):85.
7. McManus MS, Wynter-Minott S. Guidelines for chronic kidney disease: Defining, staging, and managing in primary care. The journal for Nurse practitioners. 2017 Jun 1;13(6):400-10.
8. Hultstrom M, Becirovic-Agic M, Jönsson S. Comparison of acute kidney injury of different etiology reveals in-common mechanisms of tissue damage. Physiological genomics. 2018 Mar 1;50(3):127-41.
9. Barnett LM, Cummings BS. Nephrotoxicity and renal pathophysiology: a contemporary perspective. Toxicological Sciences. 2018 Aug 1;164(2):379-90.
10. Blantz RC, Gabbai FB. Glomerular hemodynamics in pathophysiologic conditions. American Journal of Hypertension. 1989 Nov 1;2(11_Pt_2):208S-12S.
11. Hostetter TH, Troy JL, Brenner BM. Glomerular hemodynamics in experimental diabetes mellitus. Kidney international. 1981 Mar 1;19(3):410-5.
12. Baines RJ, Brunskill NJ. Tubular toxicity of proteinuria. Nature Reviews Nephrology. 2011 Mar;7(3):177-80.
13. Yarlagadda SG, Perazella MA. Drug-induced crystal nephropathy: an update. Expert opinion on drug safety. 2008 Mar 1;7(2):147-58.
14. Sauret JM, Marinides G, Wang GK. Rhabdomyolysis. American family physician. 2002 Mar 1;65(5):907-13.
15. Krane V, Wanner C. Statins, inflammation and kidney disease. Nature Reviews Nephrology. 2011 Jul;7(7):385-97.
16. Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, et al. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine. Pharmacol Res Perspect. 2017;5:1–13.
17. Boudonck KJ, Mitchell MW, Német L, Keresztes L, Nyska A, Shinar D, Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicologic pathology. 2009 Apr;37(3):280-92.
18. McGraw, N.J.; Krul, E.S.; Grunz-Borgmann, E.; Parrish, A.R. Soy-based renoprotection. World J. Nephrol. 2016, 5, 233–257.
19. Moorthi, R.N.; Vorland, C.J.; Gallant, K.M.H. Diet and Diabetic Kidney Disease: Plant Versus Animal Protein. Curr. Diabetes Rep. 2017, 17, 15.
20. Chinnappan SM, George A, Thaggikuppe P, et al. Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats. Evidence-Based Complementary and Alternative Medicine. 2019:1-6.
21. Rethinam G, Duraiswamy A, Reddy GD, Elankani P, Srinivasan SK. Nephroprotective effect of Sphaeranthus amaranthoides Burm f.: Sivakaranthai (a Siddha Kayakalpa drug) against gentamicin induced nephrotoxicity. Advances in Traditional Medicine. 2021; 20:1-10.
22. Amarasiri AM, Attanayake AP, Jayatilaka KA, Mudduwa LK. Acute nephroprotective and antioxidant activities of aqueous leaf extract of Plectranthus amboinicus (Roxb.) grown in Sri Lanka. J. Pharmacogn. Phytochem. 2018;7(4):155-61.
23. Kanase V, Mane DJ. A pharmacognostic and pharmacological review on Alstonia scholaris. Asian J Pharm Clin Res. 2018;11(12):22-6.
24. Balakrishna V, Kumar DS, Lakshmi T. Tamarindus indica L.(Fabaceae): Extent of explored use in traditional medicine. Asian J Pharm Clin Res. 2020; 13:28-32.
25. Kpemissi M, Eklu-Gadegbeku K, Veerapur VP, et al. Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies. Heliyon. 2019 ;5(3):1-35.
26. Askari H, Enayati N, Ahmadian-Attari MM, Bakhtiyari M, Alirezaei A. Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats. Iranian Journal of Pharmaceutical Research. 2021;20(1):40-52.
27. Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology. 2005 Sep 1;212(2-3):116-23.
28. Murtaza G, Karim S, Akram MR, Khan SA, Azhar S, Mumtaz A, Bin Asad MH. Caffeic acid phenethyl ester and therapeutic potentials. BioMed Research International. 2014 May 29;2014.
29. Ali BH, Al Moundhri MS. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food and chemical toxicology. 2006 Aug 1;44(8):1173-83.
30. Sundararajan R, Bharampuram A, Koduru R. A review on phytoconstituents for nephroprotective activity. Pharmacophore. 2014 Jan 1;5(1):160-82.
31. Saleem U, Ahmad B, Rehman K, Mahmood S, Alam M, Erum A. Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits. Pakistan journal of pharmaceutical sciences. 2012 Oct 1;25(4).
32. Srivastava AK, Kaushik D, Lal VK, Behera BR. Chapter-2 Prospectives of Indian Nephroprotective Medicinal Plants. Chief Editor. 2020:15.
33. Nagaraj M, Sunitha S, Varalakshmi P. Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure. Journal of applied toxicology: an international journal. 2000 Sep;20(5):413-7.
34. Shirwaikar, A; Issac, D; Malini, S (2004), "Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure", Journal of Ethnopharmacology, 90 (1), 81– 86
35. Bhattacharya S, Gachhui R, Sil PC. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food and chemical toxicology. 2013 Oct 1;60:328-40.
36. Naghizadeh B, Mansouri SM, Mashhadian NV. Crocin attenuates cisplatin-induced renal oxidative stress in rats. Food and chemical toxicology. 2010 Oct 1;48(10):2650-5.
37. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine. 2013 May 1;3(5):337-52.
38. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biological and Pharmaceutical Bulletin. 2009 Jan 1;32(1):61-7.
39. Zhu JX, Wang Y, Kong LD, Yang C, Zhang X. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Journal of ethnopharmacology. 2004 Jul 1;93(1):133-40.
40. Tavafi M, Ahmadvand H, Tamjidipoor A, Delfan B, Khalatbari AR. Satureja khozestanica essential oil ameliorates progression of diabetic nephropathy in uninephrectomized diabetic rats. Tissue and Cell. 2011 Feb 1;43(1):45-51.
41. Patel PK, Patel MA, Vyas BA, Shah DR, Gandhi TR. Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) against ethylene glycol induced urolithiasis in rats. Journal of ethnopharmacology. 2012 Oct 31;144(1):160-70.
42. Ajith TA, Aswathy MS, Hema U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and chemical toxicology. 2008 Sep 1;46(9):3178-81.
43. Rao, NK, "Anti-hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform extract", Iran Journal of Pharmacology and Therapeutics. 2006, 5, 47–50.
44. Jyothilakshmi V, Thellamudhu G, Kumar A, Khurana A, Nayak D, Kalaiselvi P. Preliminary investigation on ultra high diluted B. vulgaris in experimental urolithiasis. Homeopathy. 2013 Jul;102(03):172-8.
45. Annie S, Rajagopal PL, Malini S. Effect of Cassia auriculata Linn. root extract on cisplatin and gentamicin-induced renal injury. Phytomedicine. 2005 Aug 2;12(8):555-60.
46. Venkatesan N, Punithavathi D, Arumugam V. Curcumin prevents adriamycin nephrotoxicity in rats. British journal of pharmacology. 2000 Jan;129(2):231-4.
47. Yadav N, Khandelwal S. Therapeutic efficacy of Picroliv in chronic cadmium toxicity. Food and chemical toxicology. 2009 Apr 1;47(4):871-9.
48. Zhao YY. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review. Journal of ethnopharmacology. 2013 Aug 26;149(1):35-48.
49. Kiefer D, Pantuso T. Panax ginseng. American family physician. 2003 Oct 15;68(8):1539-42.
2. Deray G, Martinez F, Katlama C, Levaltier B, Beaufils H, Danis M, Rozenheim M, Baumelou A, Dohin E, Gentilini M, Jacobs C. Foscarnet nephrotoxicity: mechanism, incidence and prevention. American journal of nephrology. 1989 Oct 28;9(4):316-21.
3. Perazella MA. Renal vulnerability to drug toxicity. Clinical Journal of the American Society of Nephrology. 2009 Jul 1;4(7):1275-83.
4. Zhou Y, Vaidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, Miller TJ, Bonventre JV, Goering PL. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicological sciences. 2008 Jan 1;101(1):159-70.
5. Sabbahy ME, Vaidya VS. Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2011 Sep;3(5):606-18.
6. Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The clinical biochemist reviews. 2016 May;37(2):85.
7. McManus MS, Wynter-Minott S. Guidelines for chronic kidney disease: Defining, staging, and managing in primary care. The journal for Nurse practitioners. 2017 Jun 1;13(6):400-10.
8. Hultstrom M, Becirovic-Agic M, Jönsson S. Comparison of acute kidney injury of different etiology reveals in-common mechanisms of tissue damage. Physiological genomics. 2018 Mar 1;50(3):127-41.
9. Barnett LM, Cummings BS. Nephrotoxicity and renal pathophysiology: a contemporary perspective. Toxicological Sciences. 2018 Aug 1;164(2):379-90.
10. Blantz RC, Gabbai FB. Glomerular hemodynamics in pathophysiologic conditions. American Journal of Hypertension. 1989 Nov 1;2(11_Pt_2):208S-12S.
11. Hostetter TH, Troy JL, Brenner BM. Glomerular hemodynamics in experimental diabetes mellitus. Kidney international. 1981 Mar 1;19(3):410-5.
12. Baines RJ, Brunskill NJ. Tubular toxicity of proteinuria. Nature Reviews Nephrology. 2011 Mar;7(3):177-80.
13. Yarlagadda SG, Perazella MA. Drug-induced crystal nephropathy: an update. Expert opinion on drug safety. 2008 Mar 1;7(2):147-58.
14. Sauret JM, Marinides G, Wang GK. Rhabdomyolysis. American family physician. 2002 Mar 1;65(5):907-13.
15. Krane V, Wanner C. Statins, inflammation and kidney disease. Nature Reviews Nephrology. 2011 Jul;7(7):385-97.
16. Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, et al. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine. Pharmacol Res Perspect. 2017;5:1–13.
17. Boudonck KJ, Mitchell MW, Német L, Keresztes L, Nyska A, Shinar D, Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicologic pathology. 2009 Apr;37(3):280-92.
18. McGraw, N.J.; Krul, E.S.; Grunz-Borgmann, E.; Parrish, A.R. Soy-based renoprotection. World J. Nephrol. 2016, 5, 233–257.
19. Moorthi, R.N.; Vorland, C.J.; Gallant, K.M.H. Diet and Diabetic Kidney Disease: Plant Versus Animal Protein. Curr. Diabetes Rep. 2017, 17, 15.
20. Chinnappan SM, George A, Thaggikuppe P, et al. Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats. Evidence-Based Complementary and Alternative Medicine. 2019:1-6.
21. Rethinam G, Duraiswamy A, Reddy GD, Elankani P, Srinivasan SK. Nephroprotective effect of Sphaeranthus amaranthoides Burm f.: Sivakaranthai (a Siddha Kayakalpa drug) against gentamicin induced nephrotoxicity. Advances in Traditional Medicine. 2021; 20:1-10.
22. Amarasiri AM, Attanayake AP, Jayatilaka KA, Mudduwa LK. Acute nephroprotective and antioxidant activities of aqueous leaf extract of Plectranthus amboinicus (Roxb.) grown in Sri Lanka. J. Pharmacogn. Phytochem. 2018;7(4):155-61.
23. Kanase V, Mane DJ. A pharmacognostic and pharmacological review on Alstonia scholaris. Asian J Pharm Clin Res. 2018;11(12):22-6.
24. Balakrishna V, Kumar DS, Lakshmi T. Tamarindus indica L.(Fabaceae): Extent of explored use in traditional medicine. Asian J Pharm Clin Res. 2020; 13:28-32.
25. Kpemissi M, Eklu-Gadegbeku K, Veerapur VP, et al. Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies. Heliyon. 2019 ;5(3):1-35.
26. Askari H, Enayati N, Ahmadian-Attari MM, Bakhtiyari M, Alirezaei A. Protective Effects of Descurainia sophia against Gentamicin Induced Nephrotoxicity in Rats. Iranian Journal of Pharmaceutical Research. 2021;20(1):40-52.
27. Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology. 2005 Sep 1;212(2-3):116-23.
28. Murtaza G, Karim S, Akram MR, Khan SA, Azhar S, Mumtaz A, Bin Asad MH. Caffeic acid phenethyl ester and therapeutic potentials. BioMed Research International. 2014 May 29;2014.
29. Ali BH, Al Moundhri MS. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food and chemical toxicology. 2006 Aug 1;44(8):1173-83.
30. Sundararajan R, Bharampuram A, Koduru R. A review on phytoconstituents for nephroprotective activity. Pharmacophore. 2014 Jan 1;5(1):160-82.
31. Saleem U, Ahmad B, Rehman K, Mahmood S, Alam M, Erum A. Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits. Pakistan journal of pharmaceutical sciences. 2012 Oct 1;25(4).
32. Srivastava AK, Kaushik D, Lal VK, Behera BR. Chapter-2 Prospectives of Indian Nephroprotective Medicinal Plants. Chief Editor. 2020:15.
33. Nagaraj M, Sunitha S, Varalakshmi P. Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure. Journal of applied toxicology: an international journal. 2000 Sep;20(5):413-7.
34. Shirwaikar, A; Issac, D; Malini, S (2004), "Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure", Journal of Ethnopharmacology, 90 (1), 81– 86
35. Bhattacharya S, Gachhui R, Sil PC. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food and chemical toxicology. 2013 Oct 1;60:328-40.
36. Naghizadeh B, Mansouri SM, Mashhadian NV. Crocin attenuates cisplatin-induced renal oxidative stress in rats. Food and chemical toxicology. 2010 Oct 1;48(10):2650-5.
37. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine. 2013 May 1;3(5):337-52.
38. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biological and Pharmaceutical Bulletin. 2009 Jan 1;32(1):61-7.
39. Zhu JX, Wang Y, Kong LD, Yang C, Zhang X. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Journal of ethnopharmacology. 2004 Jul 1;93(1):133-40.
40. Tavafi M, Ahmadvand H, Tamjidipoor A, Delfan B, Khalatbari AR. Satureja khozestanica essential oil ameliorates progression of diabetic nephropathy in uninephrectomized diabetic rats. Tissue and Cell. 2011 Feb 1;43(1):45-51.
41. Patel PK, Patel MA, Vyas BA, Shah DR, Gandhi TR. Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) against ethylene glycol induced urolithiasis in rats. Journal of ethnopharmacology. 2012 Oct 31;144(1):160-70.
42. Ajith TA, Aswathy MS, Hema U. Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and chemical toxicology. 2008 Sep 1;46(9):3178-81.
43. Rao, NK, "Anti-hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform extract", Iran Journal of Pharmacology and Therapeutics. 2006, 5, 47–50.
44. Jyothilakshmi V, Thellamudhu G, Kumar A, Khurana A, Nayak D, Kalaiselvi P. Preliminary investigation on ultra high diluted B. vulgaris in experimental urolithiasis. Homeopathy. 2013 Jul;102(03):172-8.
45. Annie S, Rajagopal PL, Malini S. Effect of Cassia auriculata Linn. root extract on cisplatin and gentamicin-induced renal injury. Phytomedicine. 2005 Aug 2;12(8):555-60.
46. Venkatesan N, Punithavathi D, Arumugam V. Curcumin prevents adriamycin nephrotoxicity in rats. British journal of pharmacology. 2000 Jan;129(2):231-4.
47. Yadav N, Khandelwal S. Therapeutic efficacy of Picroliv in chronic cadmium toxicity. Food and chemical toxicology. 2009 Apr 1;47(4):871-9.
48. Zhao YY. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review. Journal of ethnopharmacology. 2013 Aug 26;149(1):35-48.
49. Kiefer D, Pantuso T. Panax ginseng. American family physician. 2003 Oct 15;68(8):1539-42.
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Mar 14, 2023
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Parag Manohar Barhate, & Dr. Prashant Soni. (2023). ETHNO-PHARMACOLOGICAL INVESTIGATION OF SOME PLANTS FOR THE MANAGEMENT OF NEPHROTOXICITY. Journal of Population Therapeutics and Clinical Pharmacology, 30(5), 748–757. https://doi.org/10.53555/jptcp.v30i5.3033
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Author Biographies
Parag Manohar Barhate
Research Scholar, Sarvepalli Radhakrishnan University Bhopal (M.P.)
Dr. Prashant Soni
Professor, Dr. APJ Abdul Kalam College of Pharmacy, Bhopal (M.P.)