ETHNO-PHARMACOLOGICAL INVESTIGATION OF SOME PLANTS FOR THE MANAGEMENT OF NEPHROTOXICITY

Main Article Content

Parag Manohar Barhate
Dr. Prashant Soni

Keywords

medicinal plant, phytochemicals, kidney disease, nephrotoxicity, nephroprotective.

Abstract

By 2040, kidney illnesses are anticipated to rank as the sixth greatest cause of mortality. Kidney injury is brought on by a number of physiological failures that are categorized as pre-, intra-, and post-renal causes. Pre-renal factors include things like diabetes, liver disorders, rhabdomyolysis, and intestinal microbiota, whereas post-renal causes include things like lithiasis, or blood clots in the ureters, prostate cancer, urethral blockages, prostate elongation, and urinary tract infections. Drug nephrotoxicity has also been identified as a significant contributor to kidney damage. Because certain medications have negative side effects, it is important to include additional therapy options for these disorders, such as nephroprotective agents. Plants are a rich source of nephroprotective compounds that can help at various stages of the physiological pathways that harm the kidneys. Plants are employed in traditional medicine for a variety of purposes, including as antioxidants, anti-inflammatories, diuretics, and anticancer agents. Scientific evidence is needed to substantiate some plants' nephroprotective properties because the mechanism of action of some of the plants that have been empirically employed is still unknown. The current study includes plants that reduce nephrotoxicity and phytochemicals that have nephroprotective effects

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