“SYNTHESIS, INSILICO STUDY & ANTI-PROLIFERATIVE ACTIVITY OF NEW DERIVATIVES OF TRI-ARYL IMIDAZOLE”

Main Article Content

Mr. Sandeep P. Gadhwe
Rajesh B. Patil
Chetan S Shirbhate
Govind Kankawale

Keywords

Triaryl imidazole, MTT assay, docking

Abstract

This study focuses on the process of Docking, Synthesis, and Characterization of novel chemotherapeutic agents with the potential Anticancer Activity. The aim is to discover new compounds for the anticancer activity using MCF7 cell lines on Breast Cancer that exhibit promising properties for Cancer Treatment. Imidazole offers better pharmacodynamic characteristics and directly affect membranes at high concentrations, independent of sterols and sterol esters. Recent developments in imidazole derivatives for drug development show improved efficacy & lower toxicity. The docking approach to assess the binding affinity and interaction between compounds & Protein. Radziszewski synthesis scheme with substituted benzyls and quinoline aldehyde employed to create imidazole compounds. The synthesized Compounds are subsequently analyzed using various techniques like NMR (1H), TLC, FT-IR, Mass Spectral data, Biological evaluation to assess their ability to inhibit cancer cell growth or induce cancer cell death. The findings obtained from this study seek to make a valuable contribution to the advancement of novel chemotherapeutic agents with improved anticancer properties.

Abstract 129 | pdf Downloads 79

References

(1) Sonar, J.; Pardeshi, S.; Dokhe, S.; Pawar, R.; Kharat, K.; Zine, A.; Matsagar, B.; Wu, K.; Thore, S. An Efficient Method for the Synthesis of 2,4,5-Trisubstituted Imidazoles Using Lactic Acid as Promoter. SN Appl. Sci. 2019, 1 (9), 1045. https://doi.org/10.1007/s42452-019-0935-0.
(2) Sharghi, H.; Razavi, S. F.; Aberi, M. One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1H-Imidazoles Using Mn2+ Complex of [7-Hydroxy-4-Methyl-8-Coumarinyl] Glycine as a Heterogeneous Catalyst. Catal Lett 2022, 152 (6), 1769–1783. https://doi.org/10.1007/s10562-021-03717-2.
(3) Shelke, K.; Kakade, G.; Shingate, B.; Shingare, M. MICROWAVE-INDUCED ONE-POT SYNTHESIS OF 2,4,5- TRIARYLIMIDAZOLES USING GLYOXYLIC ACID AS A CATALYST UNDER SOLVENT-FREE CONDITIONS. RJC 2008, 1 (3), 489–494.
(4) Otto, S.; Engberts, J. B. F. N. Diels_Alder Reactions in Water. Pure and Applied Chemistry 2000, 72 (7), 1365–1372. https://doi.org/10.1351/pac200072071365.
(5) Pathan, S. K.; Mahaparale, P.; Deshmukh, S.; Une, H.; Arote, R.; Sangshetti, J. Boric Acid: A Versatile Catalyst in Organic Synthesis. In Applications of Nanotechnology for Green Synthesis; Inamuddin, Asiri, A. M., Eds.; Nanotechnology in the Life Sciences; Springer International Publishing: Cham, 2020; pp 457–483. https://doi.org/10.1007/978-3-030-44176-0_17.
(6) Mason, T. J. Ultrasound in Synthetic Organic Chemistry. Chem. Soc. Rev. 1997, 26 (6), 443. https://doi.org/10.1039/cs9972600443.
(7) Siwach, A.; Verma, P. K. Synthesis and Therapeutic Potential of Imidazole Containing Compounds. BMC Chemistry 2021, 15 (1), 12. https://doi.org/10.1186/s13065-020-00730-1.
(8) Pal, S.; Khan, Md. N.; Karamthulla, S.; Choudhury, L. H. Molecular Iodine Catalyzed One-Pot Multicomponent Reactions for the Synthesis of Dihydrochromeno[4,3-b]Pyrazolo[4,3-e]Pyridin-6(7H)-Ones. RSC Adv. 2013, 3 (36), 15705. https://doi.org/10.1039/c3ra41569d.
(9) Hanoon, H. D.; Radhi, S. M.; Abbas, S. K. Simple and Efficient Synthesis of 2,4,5-Triarylsubstituted Imidazole Derivatives via a Multicomponent Reaction Using Microwave Irradiation; Karbala City, Iraq, 2019; p 020005. https://doi.org/10.1063/1.5123062.