ISONIAZID-INDUCED ANTI-CONVULSION ACTIVITY OF QUERCUS INFECTORIA EXTRACT

Main Article Content

Abdul Sohil Khan
Arpit Shrivastava
Kaynaat Khan
Amit Biswas
Prateek Kumar Jain
Harshita Jain

Keywords

Convulsions, Epilepsy, Quercus infectoria, Medicinal plants, Phytochemicals, Isoniazid

Abstract

For the purpose of discovering and create novel antiepileptic drugs, scientists and researchers are still concentrating on medicinal plants as a potential source of lead compounds. Thus this study deals with effect of Quercus infectoria extract on Isoniazid-induced convulsion. The phytochemical studies revealed the presence of volatile oil, Cumarins, anthraquinones, triterpenes, flavonoids, phenol, saponin & tannin. The total flavonoid & phenol conbtent was found to be 13.9±0.21 mgQE/g and 7.30±0.15 mgGAE/g respectively. In case of Q. infectoria the onset of seizure was at 240 seconds while seizure duration lasted for 30 seconds only. Q. infectoria does not showed dose dependent manner but delayed onset of seizure and decreases duration of seizure. This study was the first to study and revealed anticonvulsant activity of Q. infectoria and this could be the better supplement or medication for prevention and treatment of epileptic seizure arising from down regulation of GABAergic transmission oxidative stress. This finding suggests that Q. infectoria supplementation may be used as a potential neuroprotective drug.

Abstract 62 | pdf Downloads 45

References

1. Thijs RD, Surges R, O'Brien TJ, Sander JW. Epilepsy in adults. The Lancet. 2019 Feb 16;393(10172):689-701.
2. Beghi E. The epidemiology of epilepsy. Neuroepidemiology. 2020 Dec 18;54(2):185-91.
3. Shin, MD C, McNamara, MD JO. Mechanism of epilepsy. Annual review of medicine. 1994 Feb;45(1):379-89.
4. Perucca E. An introduction to antiepileptic drugs. Epilepsia. 2005 Jun;46:31-7.
5. Mohsin RA, Choudhary MI. Medicinal plants with anticonvulsant activities. Studies in Natural Products Chemistry. 2000 Jan 1;22:507-53.
6. Chauhan AK, Dobhal MP, Joshi BC. A review of medicinal plants showing anticonvulsant activity. Journal of ethnopharmacology. 1988 Jan 1;22(1):11-23.
7. Ikram M, Nowshad F. Constituents of Quercus infectoria. Planta medica. 1977 May;31(03):286-7.
8. Elham A, Arken M, Kalimanjan G, Arkin A, Iminjan M. A review of the phytochemical, pharmacological, pharmacokinetic, and toxicological evaluation of Quercus Infectoria galls. Journal of Ethnopharmacology. 2021 Jun 12;273:113592.
9. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, Nirali Prakashan. Page no. 2005:7-4

Most read articles by the same author(s)