THE FUTURE PERSPECTIVES AND NOVEL APPROACH ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM (GRDDS) WITH CURRRENT STATE
Main Article Content
Keywords
Gastroretentivedrug delivery system(GRDDs), CR;Conventional Drug Dosage Form, Bioavailability, Gastric Retention Time
Abstract
Gastroretentive drug delivery systems (GRDDs) are designed to prolong the residence time of a drugin the stomach. This can be beneficial for drugs that are destroyed by stomach acid orthat need to bedelivered in a sustained-release manner.GRDDsare a promising new technology for improving thedelivery of drugs to the gastrointestinal tract. They have the potential to improve the efficacy andsafety of drugs, and to reduce the number of side effects.The primary goal of GRDDsis to improvethe bioavailability and therapeutic efficacy of orally administered drugs.GRDDsare available inGRDDscan take various forms, including tablets, capsules, or multiparticulate systems. They areformulated using various strategies to achieve gastroretention, such as floating systems,mucoadhesive systemsor expandable systems& swelling.The primary focuses of this review paperare to first go through the fundamental idea of GRDDs, the most recent approach to GRDDs, and thesituation of GRDDsdelivery today.In this review,talk about the stomach's physiological conditionand the many components that influence GRDDS. Recently used gastrointestinal technologies suchas expandable,bio/mucoadhesive, low-and high-density-systems, and adhesive have also been brieflystudied, along with their benefits and drawbacks.
References
01.Lopes, C.M.; Bettencourt, C.; Rossi, A.; Buttini, F.; Barata, P. Overview on gastroretentive drug
delivery systems for improving drug bioavailability. Int. J. Pharm. 2016, 510, 144–158.
[PubMed]
02.Pawar H A, DhavaleR. Development and evaluation of gastroretentive floating tablets of an
antidepressant drug by thermoplastic granulation technique. beni-suef university journal of basicand applied sciences. 2014; 3:122-132.
03.Fujimori, J.; Machida, Y.; Tanaka, S.; Nagai, T. Effect of magnetically controlled gastric
residence of sustaine release tablets on bioavailability of acetaminophen. Int. J. Pharm. 1995,119, 47–55. [CrossRef]
04.Hwang, K.-M.; Cho, C.-H.; Tung, N.-T.; Kim, J.-Y.; Rhee, Y.-S.; Park, E.-S. Release kinetics of
highly porous floating tablets containing cilostazol. Eur. J. Pharm. Biopharm. 2017, 115, 39–51.
[CrossRef] [PubMed]
05.Kim, S.; Hwang, K.-M.; Park, Y.S.; Nguyen, T.-T.; Park, E.-S. Preparation and evaluation of
non-effervescent gastroretentive tablets containing pregabalin for once-daily administration anddose proportional pharmacokinetics. Int. J. Pharm. 2018, 550, 160–169. [CrossRef] [PubMed]
06.Lin, H. L., Chen, L. C., Cheng, W. T., Cheng, W. J., Ho, H. O., & Sheu, M. T. (2020). Preparation
and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System
(sf GRDDS) for Enhanced Oral Bioavailability of Nilotinib. Pharmaceutics, 12(2), 137.
07.Jassal, M., Nautiyal, U., Kundlas, J., & Singh, D. (2015). A review: Gastroretentive drug delivery
system (grdds). Indian journal of pharmaceutical and biological research, 3(1), 82.
08.Bhavsar, D. N. (2012). Advances in GRDDS: Raft forming system a review. Journal of drug
delivery and therapeutics, 2(5).
09.Vishwakarma, S. K., Mishra, J. N., & Vishwakarma, D. K. (2021). A REVIEW ON GRDDS
RECENT ADVANCES IN DRUG DELIVERY SYSTEMS AND ITS APPLICATION. WorldJournal of Pharmaceutical Research, 10(11), 1159-1175.
10.Sharma, G., Nautiyal, U., & Ahmad, S. (2019). An overview on gastroretentive drug delivery
system (GRDDS). International Journal of Health and Biological Sciences, 2(2), 1-8.
11.Dehghan, M., & Kha, F. (2009). Gastroretentive drug delivery systems: A patent perspective.
International Journal of Health Research, 2(1).
12.Tomar, A., Upadhyay, A.,Gupta, S. K., & Kumar, S. (2019). An overview on gastroretentive
drug delivery system: current approaches and advancements. Current Research in PharmaceuticalSciences, 12-16.
13.Bera, H.; Kandukuri, S.G.; Nayak, A.K.; Boddupalli, S. Alginate-sterculia gum gel-coated oil-
entrapped alginate beads for gastroretentive risperidone delivery.Carbohydr. Polym.2015,120,74–84. [CrossRef][PubMed]
14.Nappinnai, M.; Sivaneswari, S. Formulation optimization and characterization of gastroretentive
cefpodoxime proxetil mucoadhesive microspheres using 32 factorial design.J. Pharm. Res.2013,
7, 304–309. [CrossRef]
15.Pund, S.; Joshi, A.; Vasu, K.; Nivsarkar, M.; Shishoo, C. Gastroretentive delivery of rifampicin:
In vitro mucoadhesion and in vivo gamma scintigraphy.Int. J. Pharm.2011,411, 106–112.
[CrossRef][PubMed]
16.Wang, L.; Wu, Y.; Li, J.; Qiao, H.; Di, L. Rheological and mucoadhesive properties of
polysaccharide from Bletilla striata with potential use in pharmaceutics as bio-adhesive excipient.
Int. J. Biol. Macromol.2018,120, 529–536. [CrossRef][PubMed]
17.Khutoryanskiy, V.V. Advances in mucoadhesion and mucoadhesive polymers.Macromol.
Biosci.2011,11,748–764. [CrossRef]
18.Vinchurkar, K., Sainy, J., Khan, M. A., Sheetal, M. A. N. E., Mishra, D. K., & Dixit, P. (2022).
Features and Facts of a Gastroretentive Drug Delivery System-A Review. Turkish Journal ofPharmaceutical Sciences, 19(4), 476.
19.Prajapati, V.D.; Jani, G.K.; Khutliwala, T.A.; Zala, B.S. Raft forming system—An upcoming
approach of gastroretentive drug delivery system. J. Control. Release 2013, 168, 151–165.
[CrossRef]
20.Mandal, U.K.; Chatterjee, B.; Senjoti, F.G. Gastro-retentive drug delivery systems and their in
vivo success: A recent update. Asian J. Pharm. Sci. 2016, 11, 575–584. [CrossRef]
21.Prinderre, P.; Sauzet, C.; Fuxen, C. Advances in gastro retentive drug-delivery systems. Expert
Opin. Drug Deliv. 2011, 8, 1189–1203. [CrossRef]
22.Reddy, S., Bijjika, S., & Rao, S. (2017). Approaches to gastroretentive drug delivery systems:
An overview. International Journal of Research in Phytochemistry and Pharmacology, 7(3), 50-63.
23.Kumar, A., Kumari, S., & Srivastava, T. (2018). A REVIEW ON GASTRO RETENTIVE
FLOATING DRUG DELIVERY SYSTEM (GRDDS). Organized by, 418.
24.Adibkia, K., Ghanbarzadeh, S., Mohammadi, G., Atashgah, R. B., & Sabzevari, A. (2013). Gastro
retentive drug delivery systems: A review. Journal of Reports in Pharmaceutical Sciences, 2(2),190-204.
25.Gopal, S. V., Chaurasia, P. K., Pardhe, H. A., Santosh, S. S., & Sonar, N. S. (2020).
Gastroretentive drug delivery system: A systematic review. Asian Journal of Pharmacy andTechnology, 10(4), 278-284.
26.Sanghavi, R. S., Agrawal, O., & Usman, M. R. M. (2022). Gastroretentive drug delivery system:
An overview. Research Journal of Pharmacy and Technology, 15(3), 1343-1347.
27.KUMAR, A., & SRIVASTAVA, R. (2021). In vitro in vivo studies on floating microspheres for
gastroretentive drug delivery system: a review. Asian Journal of Pharmaceutical and ClinicalResearch, 13-26.
28.Patole, R., Chaware, B., Mohite, V., & Redasani, V. (2023). A Review for Gastro-Retentive Drug
Delivery System. Asian Journal of Pharmaceutical Research and Development, 11(4), 79-94.
29.Sawanny, R., Sharma, A., Jain, S., Mukherjee, S., & Khamkat, P. (2023). Gastro Retentive Drug
Delivery System: Latest Approach towards Novel Drug Delivery. Research Journal of Pharmacyand Technology, 16(1), 453-458.
30.Jeganath, S. (2022). Recent approaches of gastroretentive drug delivery system–a review. Asian
Journal of Pharmaceutics (AJP), 16(1).
31.Landge, P., Lavande, J., Swami, A., & Dharashive, V. (2023). A Review on Gastroretentive Drug
Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology, 15(1), 62-68.
32.Jeong, S.H.; Park, K. Development of sustained release fast-disintegrating tablets using various
polymer-coated ion-exchange resin complexes.Int. J. Pharm.2008,353, 195–204. [CrossRef]33.Torres, D.; Boado, L.; Blanco, D.; Vila-Jato, J.L. Comparison between aqueous and non-aqueous
solvent evaporation methods for microencapsulation of drug–resin complexes.Int. J. Pharm.
1998,173, 171–182.[CrossRef]
34.Farag, Y.; Nairn, J.G. Rate of release of organic carboxylic acids from ion-exchange resins.J.
Pharm. Sci.1988,77, 872–875. [CrossRef][PubMed]
35.El-said, I.A.; Aboelwafa, A.A.; Khalil, R.M.; ElGazayerly, O.N. Baclofen novel gastroretentive
extended release gellan gum superporous hydrogel hybrid system: In vitro and in vivo evaluation.
Durg Deliv.2016,23, 101–112. [CrossRef][PubMed]
36.Chandrashekar, G.; Udupa, N. Biodegradable Injectable Implant Systems for Long Term Drug
Delivery Using Poly (Lactic-co-glycolic) Acid Copolymers.J. Pharm. Pharmacol.1996,48,669–674. [CrossRef][PubMed]
37.Turner, P.V.; Brabb, T.; Pekow, C.; Vasbinder, M.A. Administration of substances to laboratory
animals: Routes of administration and factors to consider.J. Am. Assoc. Lab. Anim. Sci.2011
,
50, 600–613.
38.Badve, S.S.; Sher, P.; Korde, A.; Pawar, A.P. Development of hollow/porous calcium pectinate
beads for floating-pulsatile drug delivery.Eur. J. Pharm. Biopharm.2007,65, 85–93. [CrossRef]
[PubMed]
delivery systems for improving drug bioavailability. Int. J. Pharm. 2016, 510, 144–158.
[PubMed]
02.Pawar H A, DhavaleR. Development and evaluation of gastroretentive floating tablets of an
antidepressant drug by thermoplastic granulation technique. beni-suef university journal of basicand applied sciences. 2014; 3:122-132.
03.Fujimori, J.; Machida, Y.; Tanaka, S.; Nagai, T. Effect of magnetically controlled gastric
residence of sustaine release tablets on bioavailability of acetaminophen. Int. J. Pharm. 1995,119, 47–55. [CrossRef]
04.Hwang, K.-M.; Cho, C.-H.; Tung, N.-T.; Kim, J.-Y.; Rhee, Y.-S.; Park, E.-S. Release kinetics of
highly porous floating tablets containing cilostazol. Eur. J. Pharm. Biopharm. 2017, 115, 39–51.
[CrossRef] [PubMed]
05.Kim, S.; Hwang, K.-M.; Park, Y.S.; Nguyen, T.-T.; Park, E.-S. Preparation and evaluation of
non-effervescent gastroretentive tablets containing pregabalin for once-daily administration anddose proportional pharmacokinetics. Int. J. Pharm. 2018, 550, 160–169. [CrossRef] [PubMed]
06.Lin, H. L., Chen, L. C., Cheng, W. T., Cheng, W. J., Ho, H. O., & Sheu, M. T. (2020). Preparation
and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System
(sf GRDDS) for Enhanced Oral Bioavailability of Nilotinib. Pharmaceutics, 12(2), 137.
07.Jassal, M., Nautiyal, U., Kundlas, J., & Singh, D. (2015). A review: Gastroretentive drug delivery
system (grdds). Indian journal of pharmaceutical and biological research, 3(1), 82.
08.Bhavsar, D. N. (2012). Advances in GRDDS: Raft forming system a review. Journal of drug
delivery and therapeutics, 2(5).
09.Vishwakarma, S. K., Mishra, J. N., & Vishwakarma, D. K. (2021). A REVIEW ON GRDDS
RECENT ADVANCES IN DRUG DELIVERY SYSTEMS AND ITS APPLICATION. WorldJournal of Pharmaceutical Research, 10(11), 1159-1175.
10.Sharma, G., Nautiyal, U., & Ahmad, S. (2019). An overview on gastroretentive drug delivery
system (GRDDS). International Journal of Health and Biological Sciences, 2(2), 1-8.
11.Dehghan, M., & Kha, F. (2009). Gastroretentive drug delivery systems: A patent perspective.
International Journal of Health Research, 2(1).
12.Tomar, A., Upadhyay, A.,Gupta, S. K., & Kumar, S. (2019). An overview on gastroretentive
drug delivery system: current approaches and advancements. Current Research in PharmaceuticalSciences, 12-16.
13.Bera, H.; Kandukuri, S.G.; Nayak, A.K.; Boddupalli, S. Alginate-sterculia gum gel-coated oil-
entrapped alginate beads for gastroretentive risperidone delivery.Carbohydr. Polym.2015,120,74–84. [CrossRef][PubMed]
14.Nappinnai, M.; Sivaneswari, S. Formulation optimization and characterization of gastroretentive
cefpodoxime proxetil mucoadhesive microspheres using 32 factorial design.J. Pharm. Res.2013,
7, 304–309. [CrossRef]
15.Pund, S.; Joshi, A.; Vasu, K.; Nivsarkar, M.; Shishoo, C. Gastroretentive delivery of rifampicin:
In vitro mucoadhesion and in vivo gamma scintigraphy.Int. J. Pharm.2011,411, 106–112.
[CrossRef][PubMed]
16.Wang, L.; Wu, Y.; Li, J.; Qiao, H.; Di, L. Rheological and mucoadhesive properties of
polysaccharide from Bletilla striata with potential use in pharmaceutics as bio-adhesive excipient.
Int. J. Biol. Macromol.2018,120, 529–536. [CrossRef][PubMed]
17.Khutoryanskiy, V.V. Advances in mucoadhesion and mucoadhesive polymers.Macromol.
Biosci.2011,11,748–764. [CrossRef]
18.Vinchurkar, K., Sainy, J., Khan, M. A., Sheetal, M. A. N. E., Mishra, D. K., & Dixit, P. (2022).
Features and Facts of a Gastroretentive Drug Delivery System-A Review. Turkish Journal ofPharmaceutical Sciences, 19(4), 476.
19.Prajapati, V.D.; Jani, G.K.; Khutliwala, T.A.; Zala, B.S. Raft forming system—An upcoming
approach of gastroretentive drug delivery system. J. Control. Release 2013, 168, 151–165.
[CrossRef]
20.Mandal, U.K.; Chatterjee, B.; Senjoti, F.G. Gastro-retentive drug delivery systems and their in
vivo success: A recent update. Asian J. Pharm. Sci. 2016, 11, 575–584. [CrossRef]
21.Prinderre, P.; Sauzet, C.; Fuxen, C. Advances in gastro retentive drug-delivery systems. Expert
Opin. Drug Deliv. 2011, 8, 1189–1203. [CrossRef]
22.Reddy, S., Bijjika, S., & Rao, S. (2017). Approaches to gastroretentive drug delivery systems:
An overview. International Journal of Research in Phytochemistry and Pharmacology, 7(3), 50-63.
23.Kumar, A., Kumari, S., & Srivastava, T. (2018). A REVIEW ON GASTRO RETENTIVE
FLOATING DRUG DELIVERY SYSTEM (GRDDS). Organized by, 418.
24.Adibkia, K., Ghanbarzadeh, S., Mohammadi, G., Atashgah, R. B., & Sabzevari, A. (2013). Gastro
retentive drug delivery systems: A review. Journal of Reports in Pharmaceutical Sciences, 2(2),190-204.
25.Gopal, S. V., Chaurasia, P. K., Pardhe, H. A., Santosh, S. S., & Sonar, N. S. (2020).
Gastroretentive drug delivery system: A systematic review. Asian Journal of Pharmacy andTechnology, 10(4), 278-284.
26.Sanghavi, R. S., Agrawal, O., & Usman, M. R. M. (2022). Gastroretentive drug delivery system:
An overview. Research Journal of Pharmacy and Technology, 15(3), 1343-1347.
27.KUMAR, A., & SRIVASTAVA, R. (2021). In vitro in vivo studies on floating microspheres for
gastroretentive drug delivery system: a review. Asian Journal of Pharmaceutical and ClinicalResearch, 13-26.
28.Patole, R., Chaware, B., Mohite, V., & Redasani, V. (2023). A Review for Gastro-Retentive Drug
Delivery System. Asian Journal of Pharmaceutical Research and Development, 11(4), 79-94.
29.Sawanny, R., Sharma, A., Jain, S., Mukherjee, S., & Khamkat, P. (2023). Gastro Retentive Drug
Delivery System: Latest Approach towards Novel Drug Delivery. Research Journal of Pharmacyand Technology, 16(1), 453-458.
30.Jeganath, S. (2022). Recent approaches of gastroretentive drug delivery system–a review. Asian
Journal of Pharmaceutics (AJP), 16(1).
31.Landge, P., Lavande, J., Swami, A., & Dharashive, V. (2023). A Review on Gastroretentive Drug
Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology, 15(1), 62-68.
32.Jeong, S.H.; Park, K. Development of sustained release fast-disintegrating tablets using various
polymer-coated ion-exchange resin complexes.Int. J. Pharm.2008,353, 195–204. [CrossRef]33.Torres, D.; Boado, L.; Blanco, D.; Vila-Jato, J.L. Comparison between aqueous and non-aqueous
solvent evaporation methods for microencapsulation of drug–resin complexes.Int. J. Pharm.
1998,173, 171–182.[CrossRef]
34.Farag, Y.; Nairn, J.G. Rate of release of organic carboxylic acids from ion-exchange resins.J.
Pharm. Sci.1988,77, 872–875. [CrossRef][PubMed]
35.El-said, I.A.; Aboelwafa, A.A.; Khalil, R.M.; ElGazayerly, O.N. Baclofen novel gastroretentive
extended release gellan gum superporous hydrogel hybrid system: In vitro and in vivo evaluation.
Durg Deliv.2016,23, 101–112. [CrossRef][PubMed]
36.Chandrashekar, G.; Udupa, N. Biodegradable Injectable Implant Systems for Long Term Drug
Delivery Using Poly (Lactic-co-glycolic) Acid Copolymers.J. Pharm. Pharmacol.1996,48,669–674. [CrossRef][PubMed]
37.Turner, P.V.; Brabb, T.; Pekow, C.; Vasbinder, M.A. Administration of substances to laboratory
animals: Routes of administration and factors to consider.J. Am. Assoc. Lab. Anim. Sci.2011
,
50, 600–613.
38.Badve, S.S.; Sher, P.; Korde, A.; Pawar, A.P. Development of hollow/porous calcium pectinate
beads for floating-pulsatile drug delivery.Eur. J. Pharm. Biopharm.2007,65, 85–93. [CrossRef]
[PubMed]
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Sep 19, 2023
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Pal, R., Pandey, P., Nogai, L., Arushi, Anand, A., Suthar, P., SahdevKeskar, M., & Kumar, V. (2023). THE FUTURE PERSPECTIVES AND NOVEL APPROACH ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM (GRDDS) WITH CURRRENT STATE. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 594–613. https://doi.org/10.53555/jptcp.v30i17.2852
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