NEUROMODULATORY PROPERTIES OF ADANSONIA DIGITATA LEAF EXTRACT AND ITS FLAVONOIDS ON ANIMAL MODELS OF NEURODEGENERATION

Abstract

Neurodegeneration is a progressive damage of structure and function of neurons involving numerous cellular pathways leading to a condition termed as neurodegenerative disease (NDD), affecting the normal functioning of motor activity and cognition. Irrespective of the various pathways and cascades involved in initiation and progression of NDD, oxidative stress, emerges as a chief runner in executing the severity of NDD. In general, oxidative stress and mitochondrial dysfunction are known to play key roles in the pathophysiology of NDD. Adansonia digitata plant leaves extracts play a very significant role in neuroprotection as compare to synthetic medications with fewer side effects. Oxidative damage or oxidative stress leads to the production of reactive oxygen species (ROS), and leading to the peroxidation of cell membrane leading to disrupt the integrity and function of the cell membrane and causing cell death or neurodegeneration. Our study showed that groups treated with leaves extract of Adansonia Digitata significantly reduced the level of MDA and other free radicle species and have anti scavenging activity. Mineral components of the plant extract from Adansonia digitata may potentially contribute to its pain-relieving actions in neuropathic pain in addition to its flavonoid contents. The electrolytes that are most prevalent in the Adansonia digitata (Seed, Fruit, Leaf, and Bark) plant consist of Mg, Ca, Fe, Zn, and Mn. It has been reported to have a broad range of therapeutic value. Thus, plant extract of Adansonia digitata may be explored further for its potential in neuromodulation and neurodegenerative diseases.