SOLID DISPERSION TECHNIQUE TO ENHANCE THE SOLUBILITY AND BIOAVAILABILITY OF TELMISARTAN AND HYDROCHLOROTHIAZIDE

Main Article Content

Vaishali. Madhukar Vaidya
Dr. Deshraj Shyamkant Chumbhale

Keywords

Telmisartan and hydrochlorothiazide, solid dispersions, PEG 6000 and Gelucire 50/13

Abstract

Objectives: The main objective of the present investigation to develop and evaluate solid dispersions of BCS Class II drugs Telmisartan and hydrochlorothiazide employing various polymers, compatible with conventional manufacturing method to enhance solubility of poorly soluble drugs


Materials and Methods: In this study, Telmisartan and hydrochlorothiazide solid dispersion were prepared using PEG 6000 and Gelucire 50/13 by solvent evaporation method. Solid dispersions and pure Telmisartan in the form of powder were characterized in comparison with pure drug and corresponding physical mixtures in the same ratios by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), powder X-ray diffractogram, and in vitro drug release.


Results: SD formulation of both drug Telmisartan and hydrochlorothiazide was prepared by using two different carrier like PEG 6000 and Gelucire 50/13 in 1:1, 1:3, 1:5 and 1:7 drug to polymer ratio by solvent evaporation method & selected for characterization. The DSC study indicated that the crystalline nature of Telmisartan and hydrochlorothiazide was reduced to amorphous. The diffraction pattern of the solid dispersions in each figure indicates that diffraction peaks at 2ɵ values has less intensity than that of pure drugs. This indicated that the crystalline nature of drug sample was converted to amorphous. Scanning electron microscope photographs of solid dispersion seem to be more porous in nature. From the in vitro drug release profile, it can be seen that formulation PSD3 shows higher dissolution rate i.e. 97.54±2.87% compared with other formulations. It is predicted that, increasing concentration of carrier, increases the drug dissolution rate.


Conclusion: This study has shown that the solid dispersion of Telmisartan and hydrochlorothiazide using carrier can be promising formulation for solubility and dissolution enhancement. Synthetic polymers used have shown promising results in the modification of drug release from the formulations

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