OCCURRENCE OF HYPERBILIRUBINEMIA IN NEONATES GIVEN A SHORT-TERM COURSE OF CEFTRIAXONE VERSUS CEFOTAXIME FOR SEPSIS
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Keywords
Sepsis, Hyperbilirubinemia, Ceftriaxone, Cefotaxime
Abstract
Introduction: Sepsis occurring before 28 days after birth is termed as neonatal sepsis. It is a life-threatening infection responsible for significant morbidity and mortality worldwide.
Aim: To compare the incidence of hyperbilirubinemia in neonates given a short-term course of ceftriaxone versus cefotaxime for sepsis.
Methods: A retrospective study conducted in Autonomous State Medical College, Shahjahanpur & Allied Pt. Ram Prasad Bismil Memorial Hospital. Study was carried out by evaluating 110 prescriptions of neonatal sepsis. 110 prescriptions were grouped into two, ceftriaxone prescribed cases included in group-A and cefotaxime prescribed cases included in group-B. At the time of antimicrobial administration, patients were about 15-28 days old and each received at least one dose of ceftriaxone or cefotaxime during hospital admission. Patient characteristics and bilirubin levels were compared between groups.
Results: Majority of the patients were males (68.18%), weighing 3.25kg. At initial visit, an average age of patients was 21 days. Among 110 cases, elevated bilirubin levels were observed in 96(87.27%), only 14 patients had normal bilirubin levels. After treatment with antimicrobial agents, abnormally elevated bilirubin levels were noticed in 5 patients, 2 (3.50%) in ceftriaxone and 3 (5.6%) in cefotaxime treated patients. Bilirubin levels were increased in both the groups but the mean difference was not statistically significant. (p>0.05)
Conclusion: In present study we had observed hyperbilirubinemia in patients received both ceftriaxone and cefotaxime. However cefotaxime received patients had shown slightly higher bilirubin levels as compared with ceftriaxone received patients, but which is not statistically significant(p>0.05).
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Dr. Akhilesh Kumar
Assistant Professor, Department of Pediatrics, Autonomous State Medical College & Allied Pt. Ram Prasad Bismil Memorial Hospital, Shahjahanpur, Uttar Pradesh.
Dr. Rajendra Kumar
Assistant Professor, Department of Pharmacology, Autonomous State Medical College, Firozabad, Uttar Pradesh