NANOTECHNOLOGICAL AND NANOMATERIALS DENTISTRY: NEXT-GENERATION ANTIMICROBIAL THERAPY

Main Article Content

Kunal Kishor
Pooja Jha
Farha Azmeen
Shefali anand
Keerti Singh

Keywords

Nanotechnology, Nano dentistry, antimicrobial nanomaterials,, targeted drug delivery

Abstract

Nanotechnology has made its mark on almost every current field. Nanotechnological dentistry refers to the application of nanotechnology in the field of dentistry, specifically for the diagnosis, treatment, and prevention of oral health issues. Nanotechnology involves manipulating materials and devices at the nanoscale level, which is at the scale of individual atoms and molecules. This has the potential to revolutionize dentistry by offering more precise and effective solutions for various dental problems. The use of nanotechnology as a strategy to combat antimicrobial resistance has grown over the last few years in both industry and research. This is because nanomaterials have unique size-dependent features that, when used, dramatically improve human life and health.  The number of dental nanoparticles available has grown over time, and a wide spectrum of them have been explored for commercial and clinical applications. Antimicrobial nanoparticles are added to current dental compounds with restorative composite materials to prevent tooth decay and improve biocompatibility. In order to emphasize the successes of nanotechnology in dentistry as well as the present difficulties and anticipated future developments, the review thus offers a thorough analysis and in-depth examination. The management of the microbiome has undergone unprecedented breakthroughs, including the application of peptides, antibodies, phage therapy, and other nanotechnological techniques. Findings from study suggest that focused antimicrobial drug delivery employing nanoparticles modified in some way can kill resistant microbial cells. The aim of this study is to outline current research in nano dentistry and to describe the idea and development of nanoscience as well as its use in medicine.

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References

1. Angel Villegas, N., Silvero Compagnucci, M.J., Sainz Ajá, M., Rocca, D.M., Becerra, M.C., Fabián Molina, G. and Palma, S.D., 2019. Novel antibacterial resin-based filling material containing nanoparticles for the potential one-step treatment of caries. Journal of healthcare Engineering, 2019.
2. Bapat, R.A., Joshi, C.P., Bapat, P., Chaubal, T.V., Pandurangappa, R., Jnanendrappa, N., Gorain, B., Khurana, S. and Kesharwani, P., 2019. The use of nanoparticles as biomaterials in dentistry. Drug discovery today, 24(1), pp.85-98.
3. Bruniera, J.F.B., Gabriel-Silva, L., Goulart, R.S., Silva-Sousa, Y.T.C., Lara, M.G., Pitondo-Silva, A. and Miranda, C.E.S., 2020. Green synthesis, characterization, and antimicrobial evaluation of silver nanoparticles for an intracanal dressing. Brazilian Dental Journal, 31, pp.485-492.
4. Chaloupka, K., Malam, Y. and Seifalian, A.M., 2010. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends in biotechnology, 28(11), pp.580-588.
5. Durán, N., Durán, M., De Jesus, M.B., Seabra, A.B., Fávaro, W.J. and Nakazato, G., 2016. Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity. Nanomedicine: nanotechnology, biology and medicine, 12(3), pp.789-799.
6. Gronwald, B., Kozłowska, L., Kijak, K., Lietz-Kijak, D., Skomro, P., Gronwald, K. and Gronwald, H., 2023. Nanoparticles in Dentistry—Current Literature Review. Coatings, 13(1), p.102.
7. Li, X., Wang, C., Wang, L., Huang, R., Li, W.C., Wang, X., Wong, S.S.W., Cai, Z., Leung, K.C.F. and Jin, L., 2022. A glutathione-responsive silica-based nanosystem capped with in-situ polymerized cell-penetrating poly (disulfide) s for precisely modulating immuno-inflammatory responses. Journal of Colloid and Interface Science, 614, pp.322-336.
8. Montoya, C., Roldan, L., Yu, M., Valliani, S., Ta, C., Yang, M. and Orrego, S., 2023. Smart dental materials for antimicrobial applications. Bioactive Materials, 24, pp.1-19.
9. Wang, Y., Ding, Y., Deng, J., Nie, R. and Meng, X., 2023. Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ. Journal of Dentistry, p.104411.
10. Vazquez-Muñoz, R., Meza-Villezcas, A., Fournier, P.G.J., Soria-Castro, E., Juarez-Moreno, K., Gallego-Hernández, A.L., Bogdanchikova, N., Vazquez-Duhalt, R. and Huerta-Saquero, A., 2019. Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane. PloS one, 14(11), p.e0224904.