Value of Neutrophil gelatinase-associated Lipocalin in serum and peritoneal fluids in the Diagnosis of Spontaneous Bacterial Peritonitis and the Prediction of In hospital mortality
Main Article Content
Keywords
Neutrophil gelatinase-associated Lipocalin (NGAL), Lipocalin 2 (Lcn2), chronic liver disease (CLD), Spontaneous bacterial peritonitis (SBP), In hospital mortality
Abstract
Background Spontaneous bacterial peritonitis (SBP) is one of the most critical complications in chronic liver disease patients with ascites. Lipocalin‑2 (Lcn2), also known as neutrophil gelatinase‑associated lipocalin (NGAL), is a 25‑kDa protein present in peroxidase‑negative granules of neutrophils, and is released following neutrophil activation. Lipocalin‑2 is a promising marker for diagnosis of infections, especially in chronic liver diseases (CLD).
Objective This study aims to evaluate role of serum and ascitic lipocalin-2 as a reliable biomarker in diagnosis of SBP and as a predictor of short term in-hospital mortality in patients with chronic liver disease -related SBP.
Methods This case-cohort study was conducted on 80 patients with CLD &Ascites, 40 patients with SBP infections and 40 patients without SBP . All patients were subjected to measurement of lipocalin-2 levels in both serum and ascitic fluids by enzyme-linked immune-sorbent assay (ELISA) kits . For SBP cases , Siderophores production was determined among bacterial isolates quantitatively by modified CAS assay method and analyzed genetically by multiplex polymerase chain reaction (PCR) ,then cases were followed up for 30 days in hospital mortality.
Results The results indicated that ascites Lipocalin-2 was significantly higher in patients with SBP compared to those without SBP. In ROC analysis, ascites Lipocalin-2 had an AUC of 0.845 as a marker for diagnosis of SBP cases . Sixteen (40%) patients died in the hospital. In the final multivariate model, MELD score, Creatinine , INR, Total and direct bilirubin remain significant predictors of in-hospital mortality (P<0.05).
Conclusion Ascitic fluid Lipocalin-2 level can be used as a diagnostic marker of SBP in hospitalized patients with cirrhosis with high sensitivity and specificity, especially in chronic liver disease patients . MELD score remains an independent predictor of short-term survival in-hospital mortality .
References
1 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
2 Elsherif, A. A., Eldahshan, M. A., Hussein, M. S., & Mohamed, A. M. (2016). Asymptomatic Spontaneous Bacterial Peritonitis in Adult Egyptian Patients with Decompensated Liver Cirrhosis: A Prospective Cohort Study. International Journal of Advanced Biomedicine, 1(1): 5–9.
3 Albillos A, Lario M, Alvarez-Mon M. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. J Hepatol. (2014) 61:1385–96. doi: 10.1016/j.jhep.2014.08.010
4 Bunchorntavakul C, Chamroonkul N, Chavalitdhamrong D. Bacterial infections in cirrhosis: A critical review and practical guidance. World J Hepatol. (2016) 8:307–21. doi: 10.4254/wjh.v8.i6.307
5 Alexandre dA. Akin criteria as a predictor of mortality in cirrhotic patients after spontaneous bacterial peritonitis. Ann Hepatol. (2014) 13:390−5. doi: 10.1016S1665-2681(19)30870-1
6 Iliaz R, Ozpolat T, Baran B, Demir K, Kaymakoglu S, Besisik F, et al. Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers. Eur JGastroen Hepat. (2018) 30:786– 91. doi: 10.1097/MEG.0000000000001111
7 Schwabl P, Bucsics T, Soucek K, Mandorfer M, Bota S. Blacky A. Reiberger T Risk factors for development of spontaneous bacterial peritonitis and subsequent mortality in cirrhotic patients with ascites. Liver Int. (2015) 35:2121–8. doi: 10.1111/liv.12795
8 Terg R, Gadano A, Cartier M, Casciato P, Lucero R. Munoz A. Abecasis R Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: a retrospective study. Liver Int. (2009) 29:415–9. doi: 10.1111/j.1478-3231.2008.01877.x
9 Xiang, Shoushu, Juntao Tan, Chao Tan, Qian Xu, Yuanjiu Wen, Tiantian Wang, Chen Yang, and Wenlong Zhao. 2022. “Establishment and Validation of a Non-Invasive Diagnostic Nomogram to Identify Spontaneous Bacterial Peritonitis in Patients With Decompensated Cirrhosis.” Frontiers in Medicine 8(January):1–10. doi: 10.3389/fmed.2021.797363.
10 Abdel-Razik, Ahmed, Waleed Eldars, Rania Elhelaly, Ahmed A. Eldeeb, Mostafa Abdelsalam, Niveen El-Wakeel, and Alsaid Aboulmagd. 2018. “Homocysteine: A New Diagnostic Marker in Spontaneous Bacterial Peritonitis.” European Journal of Gastroenterology and Hepatology 30(7):779–85. doi: 10.1097/MEG.0000000000001109.
11 Shi, Lei, Dan Wu, Lei Wei, Suxia Liu, Peng Zhao, Bo Tu, Yangxin Xie, Yanan Liu, Xinhua Wang, Liying Liu, Xin Zhang, Zhe Xu, Fusheng Wang, and Enqiang Qin. 2017. “Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis in China: Comparative Microbiology and Therapeutic Implications.” Scientific Reports 7(April):1–7. doi: 10.1038/srep46025.
12 Fouad, T. R., Abdelsameea, E., & Elsabaawy, M. (2019). Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis. 49(3), 189–192. https://doi.org/10.1177/0049475519830265
13. Singal AK, Salameh H and Kamath PS. Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States. Aliment Pharmacol Ther 2014; 40: 105–112.
14 . Barreales M and Ferna´ ndez I. Spontaneous bacterial peritonitis. Rev Esp Enferm Dig 2011; 103: 255–263.
15 . Kaymakoglu S, Eraksoy H, Okten A, et al. Spontaneous ascitic infection in different cirrhotic groups: prevalence, risk factors and the efficacy of cefotaxime therapy. Eur J Gastroenterol Hepatol 1997; 9: 71–76.
16 . Cheong HS, Kang CI, Lee JA, et al. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis Off Publ Infect Dis Soc Am 2009; 48: 1230–1236.
17 . Tandon P and Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26–42.
18 . Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil mlipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033–1043.
19 . Berger T, Togawa A, Duncan GS, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to E. coli infection but not to ischemia reperfusion injury. Proc
Natl Acad Sci USA 2006; 103: 1834–1839.
20 . Cullaro G, Kim G, Pereira MR, et al. ascites neutrophil gelatinase-associated lipocalin identifies spontaneous bacterial peritonitis and predicts mortality in
hospitalized patients with cirrhosis. Dig Dis Sci 2017; 62: 3487–3494.
21 . Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268(14):10425-10432.
22 Bagshaw SM, Bennett M, Haase M, Haase Fielitz A, Egi M, Morimatsu H, et al.(2010):Plasma and urine neutrophil gelatinase associated lipocalin in septic versus non septic acute kidney injury in critical illness. Intensive Care Med 2010; 36:452–461.
23 Nasioudis D and Witkin SS (2015): Neutrophil gelatinase associated lipocalin and Innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
24 Ghoniema EM, Abd El Aziza AM, Abd El Motelba TM, Salama AA, and El Gazzara HM (2017): The value of lipocalin 2 as a predictive biomarker of bacterial infection in hepatic patients.Menoufia Medical Journal, Volume 30 | Number 4 | October-December 2017[Downloaded free from http://www.mmj.eg.net on Friday, April 12, 2019, IP: 197.56.184.94
25 Behairy BE, Salama EI, Allam AA, Ali MA and Abd Elaziz AM (2011):Lipocalin-2 as a Marker of Bacterial Infections in Chronic Liver Disease: A Study in Egyptian Children THE EGYPTIAN JOURNAL OF IMMUNOLOGY Vol. 18 (2), 2011 Page: 31-36.
26 Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917–921.
27 . Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. BBA Rev Cancer. 2012;1826:129–169.
28 Yilmaz A, Sevketoglu E, Gedikbasi A, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24:2387–2392.
29 . Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci. 2012;57:2362–2370. 11. Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
30 Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
31 Piano S, Brocca A, Mareso S, Angeli P. Infections complicating cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2018;38 (Suppl 1):126-33.
32 Fiore M, Maraolo AE, Gentile I, Borgia,G. Leone,S. and Sansone,p. et al. (2017).Current concepts and future strategies in the antimicrobial therapy of emerging gram-positive spontaneous bacterial peritonitis. World J Hepatol. 9(30):1166–1175
33 Acevedo J. Multiresistant bacterial infections in liver cirrhosis: clinical impact and new empirical antibiotic treatment policies. World J Hepatol.2015;7(7):916–921.
34 Abdel Salam, F., El-Toukhy, N., El- kharbotly, E., Mohamed, M., & Ameen, S. (2022). Serum Endocan Levels In Patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.118948.1538
35 ALMEIDA, P. R. L. de, LEÃO, G. S., GONÇALVES, C. D. G., PICON, R. V., & TOVO, C. V. (2018). Impact of Microbiological Changes on Spontaneous Bacterial Peritonitis in Three Different Periods Over 17 Years. Arquivos de Gastroenterologia, 55(1): 23–27.
36 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
37 Fuursted K SL, Hansen F, Dam K, Bojer MS, Hammerum A et al. Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo- beta-lactamase-1 (NDM-1). Microbes and Infection. 2012;14(2):155-158.
38 Wu CC, Wang CK, Chen YC, Lin TH, Jinn TR, Lin CT. IscR regulation of capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. PLoS One. 2014;9(9):e107812.
39 Holden VI, Bachman MA. Diverging roles of bacterial siderophores during infection. Metallomics. 2015;7(6):986-995.
40 S. Naga, I., Ghazal, A., S. Alomari, S., & Gaballah, A. (2021). Detection of Biofilm and Siderophore Encoding Genes Implicated in the Pathogenesis of Klebsiella pneumoniae Isolated from Different Clinical Specimens. Egyptian Journal of Medical Microbiology, 30(1), 101–108. https://doi.org/10.51429/ejmm30113
41 Wilson BR, Bogdan AR ,Miyazawa M, Hashimoto K, and Tsuji Y (2016): Siderophores in Iron Metabolism: From Mechanism to Therapy Potential . Trends Mol Med. 2016 December ; 22(12): 1077–1090. doi:10.1016/j.molmed.2016.10.005
42 Chon YE, Kim SU, Lee CK, Park JY, Kim DY, Han KH, et al. Community-acquired vs. nosocomial spontaneous bacterial peritonitis in patients with liver cirrhosis.Hepato-gastroenterology. 2014;61(136):2283-90.
43 Piano S, Singh V, Caraceni P, Maiwall R, Alessandria C, Fernandez J, et al. Epidemiology, predictors and outcomes of multi drug resistant (MDR) bacterial infections in patients with cirrhosis across the world. Final results of the "Global study". Digestive and Liver Disease. 2018;50(1):2-3.
44 Liu, J., Gao, Y., Wang, X., Qian, Z., Chen, J., Huang, Y., & Meng, Z. (2020). Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis : Multidrug-Resistant Pathogens and Antibiotic Strategies. 61(2), 145–153.
45 Alexopoulou, A., Vasilieva, L., Agiasotelli, D., Siranidi, K., Pouriki, S., Tsiriga, A., Toutouza, M., Dourakis, S. P., Alexopoulou, A., Vasilieva, L., & Agiasotelli, D. (2016). Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. 22(15), 4049–4056. https://doi.org/10.3748/wjg.v22.i15.4049
46 Liu H, Zhu P, Nie C, Ye Q, Gao Y, Liu H, Pang G, Han T. The value of ascitic neutrophil gelatinase-associated lipocalin in decompensated liver cirrhosis with spontaneous bacterial peritonitis. J Clin Lab Anal. 2020 Jun;34(6):e23247. doi: 10.1002/jcla.23247. Epub 2020 Feb 26. PMID: 32100329; PMCID: PMC7307354.
47 pimentel R, Leitão J, Gregório C, Santos L, Carvalho A, Figueiredo P: Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Shift in the Microbial Pattern? A Retrospective Analysis. GE Port J Gastroenterol 2022;29:256-266. doi: 10.1159/000518585
48 Hackman, Henry Kwadwo, George Osei-adjei, Andrew Gordon, Emmanuel Laryea, and Solomon Quaye. 2013. “The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates in Escherichia Coli and Klebsiella The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates .” (July 2014).
49 Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH. Global Dissemination of Carbapenemase-Producing 384 Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods. Front 385 Microbiol. 2016;7:895. Published 2016 Jun 13. doi:10.3389/fmicb.2016.00895.
50 Maniatis T., Fritsch E.F., Sambrook J. (1982) Molecular clo- ning: a laboratory manual. Cold Spring Harbor Lab. Press, New York.
51 Khazaal, M. T., El-Hendawy, H. H., Mabrouk, M. I., Faraag, A. H. I., & Bakkar, M. R. (2022). Antibiotic resistance and siderophores production by clinical Escherichia coli strains. Biotechnologia, 103(2), 169–184. https://doi.org/10.5114/bta.2022.116211
52 Kamath P, Kim W (2007): Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology,45:797-805.
53. Ascione T, Di Flumeri G, Boccia G, De Caro F. Infections in patients affected by liver cirrhosis: an update. Infez Med. 2017;25(2):91-99.
54. Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK: Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010, 139:1246-56, 1256.e1-5. 10.1053/j.gastro.2010.06.019
55. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis. 2001;33:41–48.
56. Yousef MM, Amer AI, M. Zidan A, A. Amer F, M. ElsaidTash R. Spontaneous Bacterial Peritonitis in the Medical Intensive Care Unit of a University Hospital in Egypt: Frequency, Bacteriological Profile, Risk Factors and Outcomes. The International Arabic Journal of Antimicrobial Agents. 2016;6(2):5-14.
57. Salem AM, Eliwa HM, El-saeed NH. Prevalence and characteristics of spontaneous bacterial peritonitis in hospitalized patients with ascites due to liver cirrhosis [Master thesis]. Faculty of Medicine: Cairo University; 2008.
58. Zaki MES, El Shabrawy WO, El-Eshmawy MM, Eletreby SA. The high prevalence of Listeria monocytogenes peritonitis in cirrhotic patients of an Egyptian Medical Center. Journal of Infection and Public Health. 2011;4(4):211-6.
59. El-Amin H, Sabry AMM, Ahmed RE, Makhlouf NA. Types and microbiological spectrum of infections in patients with cirrhosis: A single-centre experience in Upper Egypt. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2017;18(3):159-64.
60. Muhammad T, Shereen AA, Mabrouk R, Abdallah A. Frequency of Spontaneous Bacterial Peritonitis in Patients of Liver Cirrhosis with Ascites at Tanta University Hospitals. The Medical Journal of Cairo University. 2019;87(March):147-52.
61. Makhlouf NA, Ghaliony MA, El-Dakhli SA, Elfatth AMA, Mahmoud AA. Spontaneous Bacterial Peritonitis among Cirrhotic Patients in Upper Egypt: Clinical and Bacterial Profiles. Journal of Gastroenterology and Hepatology Research. 2019;8(6):3014-9.
62. Kamal SM, Abdelhakam SM, Massoud YM, El Hafeez A, El Aziz KA, Kamal HA. Clinical Profile of patients with Ascitic Fluid Infection at Ain Shams University Hospitals. The Egyptian Journal of Hospital Medicine. 2018;72(9):5241-50.
63. Metwally K, Fouad T, Assem M, Abdelsameea E, Yousery M. Predictors of Spontaneous Bacterial Peritonitis in Patients with Cirrhotic Ascites. Journal of clinical and translational hepatology. 2018;6(4):372-6.
64. Mir M, Rather M, Kadla S, Wani Z, Shah N, editors. Study of etiological profile and resistance pattern of spontaneous bacterial peritonitis in chronicBenha medical journal, vol. 39, issue 2, 2022 664 liver disease. Journal of gastroenterology and hepatology; 2019: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
65. Goel S, Pandey PT, Kumar A, Kumar N, Arora DK, Singh A. Clinico-bacteriological profile of spontaneous bacterial peritonitis in cirrhosis of liver with ascites. International Journal of Research in Medical Sciences. 2019;7(11):4256-60.
66. Oladimeji A, Temi A, Adekunle A et al. (2013): Prevalence of spontaneous bacterial peritonitis in liver cirrhosis with ascites. The Pan African Medical Journal, 15: 128-32.
67 Abd-Elsalam, F., Zeinelabedin, M., Abdelrahman, S., & Gabal, H. (2022). Bacteriological Profile and Antimicrobial Resistance in Ascitic Fluid of Patients with Community Acquired and Nosocomial Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.97727.1490
68 Hafez, M. Z., Abdallah, H., Abdallah, M., Khairy, K., & Abdellatif, K. (2020). Prevalence of Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Ascites and Its Pattern in Aswan University Hospital. 81(October), 1444–1448.
69 Pimentel, R., & Santos, L. (2022). Spontaneous Bacterial Peritonitis in Cirrhotic Patients : A Shift in the Microbial Pattern ? A Retrospective Analysis. 256–266. https://doi.org/10.1159/000518585
70 Taherifard, E., Hosseini-asl, M. K., & Mosayebi, M. A. (2021). Distribution and antimicrobial resistance pattern of pathogens causing spontaneous bacterial peritonitis in patients with cirrhosis at Namazi hospital , southern Iran. 13(3), 425–426.
71 Mohammed A. R.(2018). Plasma Neutrophil Gelatinase-Associated Lipocalin as a biomarker for the diagnosis of hepatorenal syndrome and spontaneous bacterial peritonitis in cirrhotic patients .
72 Ximenes RO, Farias AQ, Helou CM. Early predictors of acute kidney injury in patients with cirrhosis and bacterial infection: urinary neutrophil gelatinase‑associated lipocalin and cardiac output as reliable tools. Kidney Res Clin Pract 2015; 34:140–145.
73 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
74 Metwally, K., Fouad, T., Assem, M., Abdelsameea, E., and Yousery, M. (2018). Predictors of spontaneous bacterial peritonitis in patients with cirrhotic ascites. Journal of Clinical and Translational Hepatology; 6(4): 1–5.
75 Hamed, A. A., Morsy, K. H., & Mohammad, A. N. (2022). Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients. 88(July), 4117–4120.
76. Lee SS, Min HJ, Choi JY, et al. Usefulness of ascitic fluid lactoferrin levels in patients with liver cirrhosis. BMC Gastroenterol.2016;16(1):132.
77 Nasioudis D, Witkin SS. Neutrophil gelatinase‑associated lipocalin and innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
78 Saha, M., Sarkar, S., Sarkar, B., & Sharma, B. K. (2016). Microbial siderophores and their potential applications : a review. 3984–3999. https://doi.org/10.1007/s11356-015-4294-0
79 Calhau, V. (2014). Antimicrobial resistance determinants among Escherichia coli and Klebsiella spp. Tesis, Universira, 151.
80 Ellermann M, Arthur JC. Siderophore-mediated iron acquisition and modulation of host-bacterial interactions. Free Radic Biol Med. 2017;105:68-78.
81 Wasfi, R., Elkhatib, W. F., & Ashour, H. M. (2016). Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals. Scientific Reports, 6(December), 1–11. https://doi.org/10.1038/srep38929
82 Kumar, R., Das, A., Gaur, M., & Pattanayak, A. (2019). Genotypic validation of extended-spectrum β -lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital. Pathogens and Global Health, 113(7), 315–321. https://doi.org/10.1080/20477724.2019.1705020
83 Shakib, P., Kalani, M. T., Ramazanzadeh, R., & Rouhi, S. (2018). Molecular detection of virulence genes in Klebsiella Pneumoniae clinical isolates from Kurdistan Province , Iran Biomed Press. 5(8), 2581–2589.
84 Abduljabbar, A., Aljanaby, J., Hassan, A., & Alhasani, A. (2016). Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. 10(22), 829–843. https://doi.org/10.5897/AJMR2016.8051
85 .Fertas-Aissani R, Messai Y, Alouache S, Bakour R (2013). Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumonia strains isolated from different clinical specimens. Pathol. Biol. 61(5):209-216.
86 KUŞ H, ARSLAN, U., DAĞI, H. T., & FINDIK, D. Hastane Enfeksiyonu Etkeni Klebsiella pneumoniae İzolatlarında Çeşitli Virülans Faktörlerinin Araştırılması. Mikrobiyol Bul. 2017;51(4):329-339.
87 Aljanaby AAJ, & Alhasani, A. H. A. . Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. African Journal of Microbiology Research. 2016;10(22):829-843.
88 Daoud N., Abou Sulaiman A.and Al Kwatli K.H. VIRULENCE DETERMINANTS OF ESCHERICHIA COLI STRAINS HOSPITALS IN SYRIA. (2020). Bulletin of Pharmaceutical Sciences .Assiut University .43(2), 255–264.
89 J. Sarowska, B. Futoma-Koloch, A. Jama- Kmiecik, M. Frej-Madrzak, M. Ksiazczyk, G. Bugla-Ploskonska, et al., "Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports", Gut Pathogens, 11
90 Matin, Z., Clin, A., Antimicrob, M., Matin, F. Z., Rezatofighi, S. E., & Ardakani, M. R. (2021). Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo beta lactamase producing isolates. Annals of Clinical Microbiology and Antimicrobials, 4, 1–13. https://doi.org/10.1186/s12941-021-00457-4
91 Candan, E. D., & Aksöz, N. (2017). Escherichia Coli : Characteristics of Carbapenem Resistance and Virulence Factors. 60(December), 1–12.
92 Cholongitas E, Burroughs A (2012): The evolution in the prioritization for liver transplantation. Ann Gastroenterol., 25(1):6-13.
93 Elzouki, A., Hamad, A., Almasri, H., Ata, M., & Ashour, A. (2021). Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients Patient characteristics and outcomes. 13(10), 8–13. https://doi.org/10.7759/cureus.18999
94 Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflam- mation and cancer. BBA Rev Cancer. 2012;1826:129–169.
95 Wong, Y. J., Kalki, R. C., Lin, K. W., Kumar, R., Tan, J., Teo, E. K., & Li, J. W. (2020). Short- and long-term predictors of spontaneous bacterial peritonitis in Singapore. 61(8), 419–425.
96 Ning, N., Li, T., Zhang, J., Qu, F., Huang, J., Liu, X., Li, Z., Geng, W., & Fu, J. (2018). Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis. 1–11.
97 Rastegar, S., Moradi, M., Kalantar-Neyestanaki, D., Dehdasht, A. G., & Hosseini-Nave, H. (2021). Virulence factors, capsular serotypes and antimicrobial resistance of hypervirulent klebsiella pneumoniae and classical klebsiella pneumoniae in Southeast Iran. Infection and Chemotherapy, 53(1), 345–352. https://doi.org/10.3947/IC.2019.0027
98 Allred BE, Correnti C, Clifton MC, Strong RK, Raymond KN.2013 Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae. ACS Chem Biol 2013; 8:1882–7.
99 Hider RC, Kong X.2010 Chemistry and biology of siderophores. Nat Prod Rep 2010;27:637–57.
100 Crosa, J.H.;Walsh, C.T.2002 Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria. Microbiol. Mol. Biol. Rev. 2002, 66, 223–249.
101 Fischbach, M.A.; Lin, H.; Zhou, L.; Yu, Y.; Abergel, R.J.; Liu, D.R.; Raymond, K.N.;Wanner, B.L.; Strong, R.K.;Walsh, C.T.; et al.2006The Pathogen-Associated IroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2. Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507.
102 Garénaux, A.; Caza, M.; Dozois, C.M.2011 The Ins and Outs of Siderophore Mediated Iron Uptake by Extra-Intestinal PathogenicEscherichia coli. Vet. Microbiol. 2011, 153, 89–98.
103 Dauner M, Skerra A 2020. Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy. Chembiochem. 2020 Mar 2;21(5):601-606. doi: 10.1002/cbic.201900564. Epub 2019 Dec 13. PMID: 31613035; PMCID: PMC7079049.
104 a) K. Hantke, G. Nicholson, W. Rabsch, G. Winkelmann, Proc. Natl. Acad. Sci. USA 2003, 100,3677–3682;b)B.Bister,D.Bischoff, G. J. Nicholson, M. Valdebenito, K. Schneider,G.Winkelmann,K.Hantke,R.D.Süssmuth, BioMetals 2004, 17,471–481
105 a) M. A. Fischbach, H. Lin, L. Zhou, Y. Yu,R.J.Abergel, D. R. Liu, K. N. Raymond, B. L. Wanner,R.K.Strong, C. T. Walsh, A. Aderem, K. D. Smith, Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507;b)M.A.Fischbach, H. Lin, D. R. Liu, C. T. Walsh, Nat. Chem. Biol. 2006, 2,132–138.ChemBioChem
106 Guo, B., Wang, Q., Li, J., Gan, Z., Zhang, X., Wang, Y., & Du, H. (2017). Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection. 8(39), 65386–65396.
107 Golonka R, Yeoh BS, Vijay-Kumar M. The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity. J Innate Immun. 2019;11(3):249-262. doi: 10.1159/000494627. Epub 2019 Jan 3. PMID: 30605903; PMCID: PMC6487204.
108 Hider RC, Kong X. Chemistry and biology of siderophores. Nat Prod Rep. 2010 May; 27(5): 637–57.
109 Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. (2019). Journal of Structural Biology : X Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology: X, 2(May), 100008. https://doi.org/10.1016/j.yjsbx.2019.100008
110 Holden, V. I., Lenio, S., Kuick, R., Ramakrishnan, S. K., Shah, Y. M., & Bachman, A. (2014). Bacterial Siderophores That Evade or Overwhelm Lipocalin 2 Induce Hypoxia Inducible Factor 1 ␣ and Proinflammatory Cytokine Secretion in Cultured Respiratory Epithelial Cells. 82(9), 3826–3836. https://doi.org/10.1128/IAI.01849-14
111 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
112 Munoz-Price, L. S. & Quinn, J. P. The Spread of Klebsiella pneumoniae Carbapenemases: A Tale of Strains, Plasmids, and Transposons. Clinical Infectious Diseases 49, 1739–1741, doi: 10.1086/648078 (2009).
113 Falagas, M. E. & Karageorgopoulos, D. E. Extended-spectrum beta-lactamase-producing organisms. J Hosp Infect 73, 345–354, doi: 10.1016/j.jhin.2009.02.021 (2009).
114 Miro, E. et al. Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates. J Antimicrob Chemother 65, 661–665, doi: 10.1093/jac/dkp504 (2010)
115 Hennequin C., Robin F. (2016) Correlation between antimi- crobial resistance and virulence in Klebsiella pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis. 35(3): 333–341. https://doi.org/10.1007/s10096-015-2559-7; https://www. ncbi.nlm.nih.gov/pubmed/26718943
116 Kallau NHG, Wibawan IWT, Lukman DW, Sudarwanto MB. Detection of multi-drug resistant (MDR) Escherichia coli and tet gene prevalence at a pig farm in Kupang, Indonesia. J Adv Vet Anim Res. 2018;5(4):388–396. doi:10.5455/javar.2018.e289
117 Ibrahim, R. A. (2020). Prevalence of Virulence Genes and Their Association with Antimicrobial Resistance Among Pathogenic E . coli Isolated from Egyptian Patients with Different Clinical Infections. 1221–1236.
118 Cepas, V., & Soto, S. M. (2020). Relationship between Virulence and Resistance among Gram-Negative Bacteria. 1–11.
119 Karam MRA, Habibi M, Bouzari S. Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran. Osong Public Health Res Perspect. 2018 Oct;9(5):217-224. doi: 10.24171/j.phrp.2018.9.5.02. PMID: 30402376; PMCID: PMC6202021.
120 Sundaresan, A. K., Vincent, K., Babu, G., Mohan, M., & Ramakrishnan, J. (2022). Journal of Global Antimicrobial Resistance Association of sequence types , antimicrobial resistance and virulence genes in Indian isolates of Klebsiella pneumoniae : A comparative genomics study. Journal of Global Antimicrobial Resistance, 30, 431–441. https://doi.org/10.1016/j.jgar.2022.05.006
121 Popoiag, R. E., Panaitescu, E., Suceveanu, A. I., Suceveanu, A. P., Micu, S. I., Mazilu, L., Parepa, I., Voinea, F., Costea, D. O., Enache, F., & Fierbințeanu-braticevici, C. (2021). Spontaneous bacterial peritonitis mortality trends of cirrhotic patients in the last decade in Constanta County. 1–6. https://doi.org/10.3892/etm.2021.10164
122 Kim JJ, Tsukamoto MM, Mathur AK, Ghomri YM, Hou LA, Sheibani S, Runyon BA: Delayed paracentesis is associated with increased in-hospital mortality in patients
123 Ding, X., Yu, Y., Chen, M., Wang, C., Kang, Y., & Lou, J. (2019). Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients : community-acquired versus nosocomial infections. 1–8.
124 Cheong HS, Kang CI, Lee JA, Moon SY, Joung MK, Chung DR, Koh KC, Lee NY, Song JH, Peck KR. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis. 2009;48(9):1230–6.
125 Fernández J, Navasa M, Gómez J, Colmenero J, Vila J, Arroyo V, Rodés J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology. 2002;35(1):140–8.
126 Song JY, Jung SJ, Park CW, Sohn JW, Kim WJ, Kim MJ, Cheong HJ.Prognostic significance of infection acquisition sites in spontaneous bacterial peritonitis: nosocomial versus community acquired. J Korean Med Sci. 2006;21(4):666–71.
127 Chaulk J, Carbonneau M, Qamar H, Keough A, Chang HJ, Ma M, Kumar D, Tandon P. Third-generation cephalosporin-resistant spontaneous bacterial peritonitis: a single-Centre experience and summary of existing studies. Can J Gastroenterol Hepatol. 2014;28(2):83–8.
128 Park YH, Lee HC, Song HG, Jung S, Ryu SH, Shin JW, Chung YH, Lee YS, Suh DJ. Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea. J Gastroenterol Hepatol. 2003;18(8):927–33.
129 Heo J, Seo YS, Yim HJ, Hahn T, Park SH, Ahn SH, Park JY, Park JY, Kim MY, Park SK, et al. Clinical features and prognosis of spontaneous bacterial peritonitis in Korean patients with liver cirrhosis: a multicenter retrospective study. Gut Liver. 2009;3(3):197–204.
130 Macnaughtan J, Jalan R. Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis. Am J Gastroenterol 2015; 110:1399-410; quiz 1411.
131 Bhattacharya, C., Das-mondal, M., & Gupta, D. (2019). Annals of Hepatology Infection in cirrhosis : A prospective study. Annals of Hepatology, 18(6), 862–868. https://doi.org/10.1016/j.aohep.2019.07.010
1 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
2 Elsherif, A. A., Eldahshan, M. A., Hussein, M. S., & Mohamed, A. M. (2016). Asymptomatic Spontaneous Bacterial Peritonitis in Adult Egyptian Patients with Decompensated Liver Cirrhosis: A Prospective Cohort Study. International Journal of Advanced Biomedicine, 1(1): 5–9.
3 Albillos A, Lario M, Alvarez-Mon M. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. J Hepatol. (2014) 61:1385–96. doi: 10.1016/j.jhep.2014.08.010
4 Bunchorntavakul C, Chamroonkul N, Chavalitdhamrong D. Bacterial infections in cirrhosis: A critical review and practical guidance. World J Hepatol. (2016) 8:307–21. doi: 10.4254/wjh.v8.i6.307
5 Alexandre dA. Akin criteria as a predictor of mortality in cirrhotic patients after spontaneous bacterial peritonitis. Ann Hepatol. (2014) 13:390−5. doi: 10.1016S1665-2681(19)30870-1
6 Iliaz R, Ozpolat T, Baran B, Demir K, Kaymakoglu S, Besisik F, et al. Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers. Eur JGastroen Hepat. (2018) 30:786– 91. doi: 10.1097/MEG.0000000000001111
7 Schwabl P, Bucsics T, Soucek K, Mandorfer M, Bota S. Blacky A. Reiberger T Risk factors for development of spontaneous bacterial peritonitis and subsequent mortality in cirrhotic patients with ascites. Liver Int. (2015) 35:2121–8. doi: 10.1111/liv.12795
8 Terg R, Gadano A, Cartier M, Casciato P, Lucero R. Munoz A. Abecasis R Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: a retrospective study. Liver Int. (2009) 29:415–9. doi: 10.1111/j.1478-3231.2008.01877.x
9 Xiang, Shoushu, Juntao Tan, Chao Tan, Qian Xu, Yuanjiu Wen, Tiantian Wang, Chen Yang, and Wenlong Zhao. 2022. “Establishment and Validation of a Non-Invasive Diagnostic Nomogram to Identify Spontaneous Bacterial Peritonitis in Patients With Decompensated Cirrhosis.” Frontiers in Medicine 8(January):1–10. doi: 10.3389/fmed.2021.797363.
10 Abdel-Razik, Ahmed, Waleed Eldars, Rania Elhelaly, Ahmed A. Eldeeb, Mostafa Abdelsalam, Niveen El-Wakeel, and Alsaid Aboulmagd. 2018. “Homocysteine: A New Diagnostic Marker in Spontaneous Bacterial Peritonitis.” European Journal of Gastroenterology and Hepatology 30(7):779–85. doi: 10.1097/MEG.0000000000001109.
11 Shi, Lei, Dan Wu, Lei Wei, Suxia Liu, Peng Zhao, Bo Tu, Yangxin Xie, Yanan Liu, Xinhua Wang, Liying Liu, Xin Zhang, Zhe Xu, Fusheng Wang, and Enqiang Qin. 2017. “Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis in China: Comparative Microbiology and Therapeutic Implications.” Scientific Reports 7(April):1–7. doi: 10.1038/srep46025.
12 Fouad, T. R., Abdelsameea, E., & Elsabaawy, M. (2019). Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis. 49(3), 189–192. https://doi.org/10.1177/0049475519830265
13. Singal AK, Salameh H and Kamath PS. Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States. Aliment Pharmacol Ther 2014; 40: 105–112.
14 . Barreales M and Ferna´ ndez I. Spontaneous bacterial peritonitis. Rev Esp Enferm Dig 2011; 103: 255–263.
15 . Kaymakoglu S, Eraksoy H, Okten A, et al. Spontaneous ascitic infection in different cirrhotic groups: prevalence, risk factors and the efficacy of cefotaxime therapy. Eur J Gastroenterol Hepatol 1997; 9: 71–76.
16 . Cheong HS, Kang CI, Lee JA, et al. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis Off Publ Infect Dis Soc Am 2009; 48: 1230–1236.
17 . Tandon P and Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26–42.
18 . Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil mlipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033–1043.
19 . Berger T, Togawa A, Duncan GS, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to E. coli infection but not to ischemia reperfusion injury. Proc
Natl Acad Sci USA 2006; 103: 1834–1839.
20 . Cullaro G, Kim G, Pereira MR, et al. ascites neutrophil gelatinase-associated lipocalin identifies spontaneous bacterial peritonitis and predicts mortality in
hospitalized patients with cirrhosis. Dig Dis Sci 2017; 62: 3487–3494.
21 . Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268(14):10425-10432.
22 Bagshaw SM, Bennett M, Haase M, Haase Fielitz A, Egi M, Morimatsu H, et al.(2010):Plasma and urine neutrophil gelatinase associated lipocalin in septic versus non septic acute kidney injury in critical illness. Intensive Care Med 2010; 36:452–461.
23 Nasioudis D and Witkin SS (2015): Neutrophil gelatinase associated lipocalin and Innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
24 Ghoniema EM, Abd El Aziza AM, Abd El Motelba TM, Salama AA, and El Gazzara HM (2017): The value of lipocalin 2 as a predictive biomarker of bacterial infection in hepatic patients.Menoufia Medical Journal, Volume 30 | Number 4 | October-December 2017[Downloaded free from http://www.mmj.eg.net on Friday, April 12, 2019, IP: 197.56.184.94
25 Behairy BE, Salama EI, Allam AA, Ali MA and Abd Elaziz AM (2011):Lipocalin-2 as a Marker of Bacterial Infections in Chronic Liver Disease: A Study in Egyptian Children THE EGYPTIAN JOURNAL OF IMMUNOLOGY Vol. 18 (2), 2011 Page: 31-36.
26 Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917–921.
27 . Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. BBA Rev Cancer. 2012;1826:129–169.
28 Yilmaz A, Sevketoglu E, Gedikbasi A, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24:2387–2392.
29 . Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci. 2012;57:2362–2370. 11. Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
30 Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
31 Piano S, Brocca A, Mareso S, Angeli P. Infections complicating cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2018;38 (Suppl 1):126-33.
32 Fiore M, Maraolo AE, Gentile I, Borgia,G. Leone,S. and Sansone,p. et al. (2017).Current concepts and future strategies in the antimicrobial therapy of emerging gram-positive spontaneous bacterial peritonitis. World J Hepatol. 9(30):1166–1175
33 Acevedo J. Multiresistant bacterial infections in liver cirrhosis: clinical impact and new empirical antibiotic treatment policies. World J Hepatol.2015;7(7):916–921.
34 Abdel Salam, F., El-Toukhy, N., El- kharbotly, E., Mohamed, M., & Ameen, S. (2022). Serum Endocan Levels In Patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.118948.1538
35 ALMEIDA, P. R. L. de, LEÃO, G. S., GONÇALVES, C. D. G., PICON, R. V., & TOVO, C. V. (2018). Impact of Microbiological Changes on Spontaneous Bacterial Peritonitis in Three Different Periods Over 17 Years. Arquivos de Gastroenterologia, 55(1): 23–27.
36 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
37 Fuursted K SL, Hansen F, Dam K, Bojer MS, Hammerum A et al. Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo- beta-lactamase-1 (NDM-1). Microbes and Infection. 2012;14(2):155-158.
38 Wu CC, Wang CK, Chen YC, Lin TH, Jinn TR, Lin CT. IscR regulation of capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. PLoS One. 2014;9(9):e107812.
39 Holden VI, Bachman MA. Diverging roles of bacterial siderophores during infection. Metallomics. 2015;7(6):986-995.
40 S. Naga, I., Ghazal, A., S. Alomari, S., & Gaballah, A. (2021). Detection of Biofilm and Siderophore Encoding Genes Implicated in the Pathogenesis of Klebsiella pneumoniae Isolated from Different Clinical Specimens. Egyptian Journal of Medical Microbiology, 30(1), 101–108. https://doi.org/10.51429/ejmm30113
41 Wilson BR, Bogdan AR ,Miyazawa M, Hashimoto K, and Tsuji Y (2016): Siderophores in Iron Metabolism: From Mechanism to Therapy Potential . Trends Mol Med. 2016 December ; 22(12): 1077–1090. doi:10.1016/j.molmed.2016.10.005
42 Chon YE, Kim SU, Lee CK, Park JY, Kim DY, Han KH, et al. Community-acquired vs. nosocomial spontaneous bacterial peritonitis in patients with liver cirrhosis.Hepato-gastroenterology. 2014;61(136):2283-90.
43 Piano S, Singh V, Caraceni P, Maiwall R, Alessandria C, Fernandez J, et al. Epidemiology, predictors and outcomes of multi drug resistant (MDR) bacterial infections in patients with cirrhosis across the world. Final results of the "Global study". Digestive and Liver Disease. 2018;50(1):2-3.
44 Liu, J., Gao, Y., Wang, X., Qian, Z., Chen, J., Huang, Y., & Meng, Z. (2020). Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis : Multidrug-Resistant Pathogens and Antibiotic Strategies. 61(2), 145–153.
45 Alexopoulou, A., Vasilieva, L., Agiasotelli, D., Siranidi, K., Pouriki, S., Tsiriga, A., Toutouza, M., Dourakis, S. P., Alexopoulou, A., Vasilieva, L., & Agiasotelli, D. (2016). Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. 22(15), 4049–4056. https://doi.org/10.3748/wjg.v22.i15.4049
46 Liu H, Zhu P, Nie C, Ye Q, Gao Y, Liu H, Pang G, Han T. The value of ascitic neutrophil gelatinase-associated lipocalin in decompensated liver cirrhosis with spontaneous bacterial peritonitis. J Clin Lab Anal. 2020 Jun;34(6):e23247. doi: 10.1002/jcla.23247. Epub 2020 Feb 26. PMID: 32100329; PMCID: PMC7307354.
47 pimentel R, Leitão J, Gregório C, Santos L, Carvalho A, Figueiredo P: Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Shift in the Microbial Pattern? A Retrospective Analysis. GE Port J Gastroenterol 2022;29:256-266. doi: 10.1159/000518585
48 Hackman, Henry Kwadwo, George Osei-adjei, Andrew Gordon, Emmanuel Laryea, and Solomon Quaye. 2013. “The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates in Escherichia Coli and Klebsiella The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates .” (July 2014).
49 Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH. Global Dissemination of Carbapenemase-Producing 384 Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods. Front 385 Microbiol. 2016;7:895. Published 2016 Jun 13. doi:10.3389/fmicb.2016.00895.
50 Maniatis T., Fritsch E.F., Sambrook J. (1982) Molecular clo- ning: a laboratory manual. Cold Spring Harbor Lab. Press, New York.
51 Khazaal, M. T., El-Hendawy, H. H., Mabrouk, M. I., Faraag, A. H. I., & Bakkar, M. R. (2022). Antibiotic resistance and siderophores production by clinical Escherichia coli strains. Biotechnologia, 103(2), 169–184. https://doi.org/10.5114/bta.2022.116211
52 Kamath P, Kim W (2007): Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology,45:797-805.
53. Ascione T, Di Flumeri G, Boccia G, De Caro F. Infections in patients affected by liver cirrhosis: an update. Infez Med. 2017;25(2):91-99.
54. Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK: Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010, 139:1246-56, 1256.e1-5. 10.1053/j.gastro.2010.06.019
55. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis. 2001;33:41–48.
56. Yousef MM, Amer AI, M. Zidan A, A. Amer F, M. ElsaidTash R. Spontaneous Bacterial Peritonitis in the Medical Intensive Care Unit of a University Hospital in Egypt: Frequency, Bacteriological Profile, Risk Factors and Outcomes. The International Arabic Journal of Antimicrobial Agents. 2016;6(2):5-14.
57. Salem AM, Eliwa HM, El-saeed NH. Prevalence and characteristics of spontaneous bacterial peritonitis in hospitalized patients with ascites due to liver cirrhosis [Master thesis]. Faculty of Medicine: Cairo University; 2008.
58. Zaki MES, El Shabrawy WO, El-Eshmawy MM, Eletreby SA. The high prevalence of Listeria monocytogenes peritonitis in cirrhotic patients of an Egyptian Medical Center. Journal of Infection and Public Health. 2011;4(4):211-6.
59. El-Amin H, Sabry AMM, Ahmed RE, Makhlouf NA. Types and microbiological spectrum of infections in patients with cirrhosis: A single-centre experience in Upper Egypt. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2017;18(3):159-64.
60. Muhammad T, Shereen AA, Mabrouk R, Abdallah A. Frequency of Spontaneous Bacterial Peritonitis in Patients of Liver Cirrhosis with Ascites at Tanta University Hospitals. The Medical Journal of Cairo University. 2019;87(March):147-52.
61. Makhlouf NA, Ghaliony MA, El-Dakhli SA, Elfatth AMA, Mahmoud AA. Spontaneous Bacterial Peritonitis among Cirrhotic Patients in Upper Egypt: Clinical and Bacterial Profiles. Journal of Gastroenterology and Hepatology Research. 2019;8(6):3014-9.
62. Kamal SM, Abdelhakam SM, Massoud YM, El Hafeez A, El Aziz KA, Kamal HA. Clinical Profile of patients with Ascitic Fluid Infection at Ain Shams University Hospitals. The Egyptian Journal of Hospital Medicine. 2018;72(9):5241-50.
63. Metwally K, Fouad T, Assem M, Abdelsameea E, Yousery M. Predictors of Spontaneous Bacterial Peritonitis in Patients with Cirrhotic Ascites. Journal of clinical and translational hepatology. 2018;6(4):372-6.
64. Mir M, Rather M, Kadla S, Wani Z, Shah N, editors. Study of etiological profile and resistance pattern of spontaneous bacterial peritonitis in chronicBenha medical journal, vol. 39, issue 2, 2022 664 liver disease. Journal of gastroenterology and hepatology; 2019: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
65. Goel S, Pandey PT, Kumar A, Kumar N, Arora DK, Singh A. Clinico-bacteriological profile of spontaneous bacterial peritonitis in cirrhosis of liver with ascites. International Journal of Research in Medical Sciences. 2019;7(11):4256-60.
66. Oladimeji A, Temi A, Adekunle A et al. (2013): Prevalence of spontaneous bacterial peritonitis in liver cirrhosis with ascites. The Pan African Medical Journal, 15: 128-32.
67 Abd-Elsalam, F., Zeinelabedin, M., Abdelrahman, S., & Gabal, H. (2022). Bacteriological Profile and Antimicrobial Resistance in Ascitic Fluid of Patients with Community Acquired and Nosocomial Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.97727.1490
68 Hafez, M. Z., Abdallah, H., Abdallah, M., Khairy, K., & Abdellatif, K. (2020). Prevalence of Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Ascites and Its Pattern in Aswan University Hospital. 81(October), 1444–1448.
69 Pimentel, R., & Santos, L. (2022). Spontaneous Bacterial Peritonitis in Cirrhotic Patients : A Shift in the Microbial Pattern ? A Retrospective Analysis. 256–266. https://doi.org/10.1159/000518585
70 Taherifard, E., Hosseini-asl, M. K., & Mosayebi, M. A. (2021). Distribution and antimicrobial resistance pattern of pathogens causing spontaneous bacterial peritonitis in patients with cirrhosis at Namazi hospital , southern Iran. 13(3), 425–426.
71 Mohammed A. R.(2018). Plasma Neutrophil Gelatinase-Associated Lipocalin as a biomarker for the diagnosis of hepatorenal syndrome and spontaneous bacterial peritonitis in cirrhotic patients .
72 Ximenes RO, Farias AQ, Helou CM. Early predictors of acute kidney injury in patients with cirrhosis and bacterial infection: urinary neutrophil gelatinase‑associated lipocalin and cardiac output as reliable tools. Kidney Res Clin Pract 2015; 34:140–145.
73 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
74 Metwally, K., Fouad, T., Assem, M., Abdelsameea, E., and Yousery, M. (2018). Predictors of spontaneous bacterial peritonitis in patients with cirrhotic ascites. Journal of Clinical and Translational Hepatology; 6(4): 1–5.
75 Hamed, A. A., Morsy, K. H., & Mohammad, A. N. (2022). Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients. 88(July), 4117–4120.
76. Lee SS, Min HJ, Choi JY, et al. Usefulness of ascitic fluid lactoferrin levels in patients with liver cirrhosis. BMC Gastroenterol.2016;16(1):132.
77 Nasioudis D, Witkin SS. Neutrophil gelatinase‑associated lipocalin and innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
78 Saha, M., Sarkar, S., Sarkar, B., & Sharma, B. K. (2016). Microbial siderophores and their potential applications : a review. 3984–3999. https://doi.org/10.1007/s11356-015-4294-0
79 Calhau, V. (2014). Antimicrobial resistance determinants among Escherichia coli and Klebsiella spp. Tesis, Universira, 151.
80 Ellermann M, Arthur JC. Siderophore-mediated iron acquisition and modulation of host-bacterial interactions. Free Radic Biol Med. 2017;105:68-78.
81 Wasfi, R., Elkhatib, W. F., & Ashour, H. M. (2016). Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals. Scientific Reports, 6(December), 1–11. https://doi.org/10.1038/srep38929
82 Kumar, R., Das, A., Gaur, M., & Pattanayak, A. (2019). Genotypic validation of extended-spectrum β -lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital. Pathogens and Global Health, 113(7), 315–321. https://doi.org/10.1080/20477724.2019.1705020
83 Shakib, P., Kalani, M. T., Ramazanzadeh, R., & Rouhi, S. (2018). Molecular detection of virulence genes in Klebsiella Pneumoniae clinical isolates from Kurdistan Province , Iran Biomed Press. 5(8), 2581–2589.
84 Abduljabbar, A., Aljanaby, J., Hassan, A., & Alhasani, A. (2016). Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. 10(22), 829–843. https://doi.org/10.5897/AJMR2016.8051
85 .Fertas-Aissani R, Messai Y, Alouache S, Bakour R (2013). Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumonia strains isolated from different clinical specimens. Pathol. Biol. 61(5):209-216.
86 KUŞ H, ARSLAN, U., DAĞI, H. T., & FINDIK, D. Hastane Enfeksiyonu Etkeni Klebsiella pneumoniae İzolatlarında Çeşitli Virülans Faktörlerinin Araştırılması. Mikrobiyol Bul. 2017;51(4):329-339.
87 Aljanaby AAJ, & Alhasani, A. H. A. . Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. African Journal of Microbiology Research. 2016;10(22):829-843.
88 Daoud N., Abou Sulaiman A.and Al Kwatli K.H. VIRULENCE DETERMINANTS OF ESCHERICHIA COLI STRAINS HOSPITALS IN SYRIA. (2020). Bulletin of Pharmaceutical Sciences .Assiut University .43(2), 255–264.
89 J. Sarowska, B. Futoma-Koloch, A. Jama- Kmiecik, M. Frej-Madrzak, M. Ksiazczyk, G. Bugla-Ploskonska, et al., "Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports", Gut Pathogens, 11
90 Matin, Z., Clin, A., Antimicrob, M., Matin, F. Z., Rezatofighi, S. E., & Ardakani, M. R. (2021). Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo beta lactamase producing isolates. Annals of Clinical Microbiology and Antimicrobials, 4, 1–13. https://doi.org/10.1186/s12941-021-00457-4
91 Candan, E. D., & Aksöz, N. (2017). Escherichia Coli : Characteristics of Carbapenem Resistance and Virulence Factors. 60(December), 1–12.
92 Cholongitas E, Burroughs A (2012): The evolution in the prioritization for liver transplantation. Ann Gastroenterol., 25(1):6-13.
93 Elzouki, A., Hamad, A., Almasri, H., Ata, M., & Ashour, A. (2021). Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients Patient characteristics and outcomes. 13(10), 8–13. https://doi.org/10.7759/cureus.18999
94 Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflam- mation and cancer. BBA Rev Cancer. 2012;1826:129–169.
95 Wong, Y. J., Kalki, R. C., Lin, K. W., Kumar, R., Tan, J., Teo, E. K., & Li, J. W. (2020). Short- and long-term predictors of spontaneous bacterial peritonitis in Singapore. 61(8), 419–425.
96 Ning, N., Li, T., Zhang, J., Qu, F., Huang, J., Liu, X., Li, Z., Geng, W., & Fu, J. (2018). Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis. 1–11.
97 Rastegar, S., Moradi, M., Kalantar-Neyestanaki, D., Dehdasht, A. G., & Hosseini-Nave, H. (2021). Virulence factors, capsular serotypes and antimicrobial resistance of hypervirulent klebsiella pneumoniae and classical klebsiella pneumoniae in Southeast Iran. Infection and Chemotherapy, 53(1), 345–352. https://doi.org/10.3947/IC.2019.0027
98 Allred BE, Correnti C, Clifton MC, Strong RK, Raymond KN.2013 Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae. ACS Chem Biol 2013; 8:1882–7.
99 Hider RC, Kong X.2010 Chemistry and biology of siderophores. Nat Prod Rep 2010;27:637–57.
100 Crosa, J.H.;Walsh, C.T.2002 Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria. Microbiol. Mol. Biol. Rev. 2002, 66, 223–249.
101 Fischbach, M.A.; Lin, H.; Zhou, L.; Yu, Y.; Abergel, R.J.; Liu, D.R.; Raymond, K.N.;Wanner, B.L.; Strong, R.K.;Walsh, C.T.; et al.2006The Pathogen-Associated IroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2. Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507.
102 Garénaux, A.; Caza, M.; Dozois, C.M.2011 The Ins and Outs of Siderophore Mediated Iron Uptake by Extra-Intestinal PathogenicEscherichia coli. Vet. Microbiol. 2011, 153, 89–98.
103 Dauner M, Skerra A 2020. Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy. Chembiochem. 2020 Mar 2;21(5):601-606. doi: 10.1002/cbic.201900564. Epub 2019 Dec 13. PMID: 31613035; PMCID: PMC7079049.
104 a) K. Hantke, G. Nicholson, W. Rabsch, G. Winkelmann, Proc. Natl. Acad. Sci. USA 2003, 100,3677–3682;b)B.Bister,D.Bischoff, G. J. Nicholson, M. Valdebenito, K. Schneider,G.Winkelmann,K.Hantke,R.D.Süssmuth, BioMetals 2004, 17,471–481
105 a) M. A. Fischbach, H. Lin, L. Zhou, Y. Yu,R.J.Abergel, D. R. Liu, K. N. Raymond, B. L. Wanner,R.K.Strong, C. T. Walsh, A. Aderem, K. D. Smith, Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507;b)M.A.Fischbach, H. Lin, D. R. Liu, C. T. Walsh, Nat. Chem. Biol. 2006, 2,132–138.ChemBioChem
106 Guo, B., Wang, Q., Li, J., Gan, Z., Zhang, X., Wang, Y., & Du, H. (2017). Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection. 8(39), 65386–65396.
107 Golonka R, Yeoh BS, Vijay-Kumar M. The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity. J Innate Immun. 2019;11(3):249-262. doi: 10.1159/000494627. Epub 2019 Jan 3. PMID: 30605903; PMCID: PMC6487204.
108 Hider RC, Kong X. Chemistry and biology of siderophores. Nat Prod Rep. 2010 May; 27(5): 637–57.
109 Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. (2019). Journal of Structural Biology : X Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology: X, 2(May), 100008. https://doi.org/10.1016/j.yjsbx.2019.100008
110 Holden, V. I., Lenio, S., Kuick, R., Ramakrishnan, S. K., Shah, Y. M., & Bachman, A. (2014). Bacterial Siderophores That Evade or Overwhelm Lipocalin 2 Induce Hypoxia Inducible Factor 1 ␣ and Proinflammatory Cytokine Secretion in Cultured Respiratory Epithelial Cells. 82(9), 3826–3836. https://doi.org/10.1128/IAI.01849-14
111 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
112 Munoz-Price, L. S. & Quinn, J. P. The Spread of Klebsiella pneumoniae Carbapenemases: A Tale of Strains, Plasmids, and Transposons. Clinical Infectious Diseases 49, 1739–1741, doi: 10.1086/648078 (2009).
113 Falagas, M. E. & Karageorgopoulos, D. E. Extended-spectrum beta-lactamase-producing organisms. J Hosp Infect 73, 345–354, doi: 10.1016/j.jhin.2009.02.021 (2009).
114 Miro, E. et al. Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates. J Antimicrob Chemother 65, 661–665, doi: 10.1093/jac/dkp504 (2010)
115 Hennequin C., Robin F. (2016) Correlation between antimi- crobial resistance and virulence in Klebsiella pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis. 35(3): 333–341. https://doi.org/10.1007/s10096-015-2559-7; https://www. ncbi.nlm.nih.gov/pubmed/26718943
116 Kallau NHG, Wibawan IWT, Lukman DW, Sudarwanto MB. Detection of multi-drug resistant (MDR) Escherichia coli and tet gene prevalence at a pig farm in Kupang, Indonesia. J Adv Vet Anim Res. 2018;5(4):388–396. doi:10.5455/javar.2018.e289
117 Ibrahim, R. A. (2020). Prevalence of Virulence Genes and Their Association with Antimicrobial Resistance Among Pathogenic E . coli Isolated from Egyptian Patients with Different Clinical Infections. 1221–1236.
118 Cepas, V., & Soto, S. M. (2020). Relationship between Virulence and Resistance among Gram-Negative Bacteria. 1–11.
119 Karam MRA, Habibi M, Bouzari S. Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran. Osong Public Health Res Perspect. 2018 Oct;9(5):217-224. doi: 10.24171/j.phrp.2018.9.5.02. PMID: 30402376; PMCID: PMC6202021.
120 Sundaresan, A. K., Vincent, K., Babu, G., Mohan, M., & Ramakrishnan, J. (2022). Journal of Global Antimicrobial Resistance Association of sequence types , antimicrobial resistance and virulence genes in Indian isolates of Klebsiella pneumoniae : A comparative genomics study. Journal of Global Antimicrobial Resistance, 30, 431–441. https://doi.org/10.1016/j.jgar.2022.05.006
121 Popoiag, R. E., Panaitescu, E., Suceveanu, A. I., Suceveanu, A. P., Micu, S. I., Mazilu, L., Parepa, I., Voinea, F., Costea, D. O., Enache, F., & Fierbințeanu-braticevici, C. (2021). Spontaneous bacterial peritonitis mortality trends of cirrhotic patients in the last decade in Constanta County. 1–6. https://doi.org/10.3892/etm.2021.10164
122 Kim JJ, Tsukamoto MM, Mathur AK, Ghomri YM, Hou LA, Sheibani S, Runyon BA: Delayed paracentesis is associated with increased in-hospital mortality in patients
123 Ding, X., Yu, Y., Chen, M., Wang, C., Kang, Y., & Lou, J. (2019). Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients : community-acquired versus nosocomial infections. 1–8.
124 Cheong HS, Kang CI, Lee JA, Moon SY, Joung MK, Chung DR, Koh KC, Lee NY, Song JH, Peck KR. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis. 2009;48(9):1230–6.
125 Fernández J, Navasa M, Gómez J, Colmenero J, Vila J, Arroyo V, Rodés J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology. 2002;35(1):140–8.
126 Song JY, Jung SJ, Park CW, Sohn JW, Kim WJ, Kim MJ, Cheong HJ.Prognostic significance of infection acquisition sites in spontaneous bacterial peritonitis: nosocomial versus community acquired. J Korean Med Sci. 2006;21(4):666–71.
127 Chaulk J, Carbonneau M, Qamar H, Keough A, Chang HJ, Ma M, Kumar D, Tandon P. Third-generation cephalosporin-resistant spontaneous bacterial peritonitis: a single-Centre experience and summary of existing studies. Can J Gastroenterol Hepatol. 2014;28(2):83–8.
128 Park YH, Lee HC, Song HG, Jung S, Ryu SH, Shin JW, Chung YH, Lee YS, Suh DJ. Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea. J Gastroenterol Hepatol. 2003;18(8):927–33.
129 Heo J, Seo YS, Yim HJ, Hahn T, Park SH, Ahn SH, Park JY, Park JY, Kim MY, Park SK, et al. Clinical features and prognosis of spontaneous bacterial peritonitis in Korean patients with liver cirrhosis: a multicenter retrospective study. Gut Liver. 2009;3(3):197–204.
130 Macnaughtan J, Jalan R. Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis. Am J Gastroenterol 2015; 110:1399-410; quiz 1411.
131 Bhattacharya, C., Das-mondal, M., & Gupta, D. (2019). Annals of Hepatology Infection in cirrhosis : A prospective study. Annals of Hepatology, 18(6), 862–868. https://doi.org/10.1016/j.aohep.2019.07.010
2 Elsherif, A. A., Eldahshan, M. A., Hussein, M. S., & Mohamed, A. M. (2016). Asymptomatic Spontaneous Bacterial Peritonitis in Adult Egyptian Patients with Decompensated Liver Cirrhosis: A Prospective Cohort Study. International Journal of Advanced Biomedicine, 1(1): 5–9.
3 Albillos A, Lario M, Alvarez-Mon M. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. J Hepatol. (2014) 61:1385–96. doi: 10.1016/j.jhep.2014.08.010
4 Bunchorntavakul C, Chamroonkul N, Chavalitdhamrong D. Bacterial infections in cirrhosis: A critical review and practical guidance. World J Hepatol. (2016) 8:307–21. doi: 10.4254/wjh.v8.i6.307
5 Alexandre dA. Akin criteria as a predictor of mortality in cirrhotic patients after spontaneous bacterial peritonitis. Ann Hepatol. (2014) 13:390−5. doi: 10.1016S1665-2681(19)30870-1
6 Iliaz R, Ozpolat T, Baran B, Demir K, Kaymakoglu S, Besisik F, et al. Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers. Eur JGastroen Hepat. (2018) 30:786– 91. doi: 10.1097/MEG.0000000000001111
7 Schwabl P, Bucsics T, Soucek K, Mandorfer M, Bota S. Blacky A. Reiberger T Risk factors for development of spontaneous bacterial peritonitis and subsequent mortality in cirrhotic patients with ascites. Liver Int. (2015) 35:2121–8. doi: 10.1111/liv.12795
8 Terg R, Gadano A, Cartier M, Casciato P, Lucero R. Munoz A. Abecasis R Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: a retrospective study. Liver Int. (2009) 29:415–9. doi: 10.1111/j.1478-3231.2008.01877.x
9 Xiang, Shoushu, Juntao Tan, Chao Tan, Qian Xu, Yuanjiu Wen, Tiantian Wang, Chen Yang, and Wenlong Zhao. 2022. “Establishment and Validation of a Non-Invasive Diagnostic Nomogram to Identify Spontaneous Bacterial Peritonitis in Patients With Decompensated Cirrhosis.” Frontiers in Medicine 8(January):1–10. doi: 10.3389/fmed.2021.797363.
10 Abdel-Razik, Ahmed, Waleed Eldars, Rania Elhelaly, Ahmed A. Eldeeb, Mostafa Abdelsalam, Niveen El-Wakeel, and Alsaid Aboulmagd. 2018. “Homocysteine: A New Diagnostic Marker in Spontaneous Bacterial Peritonitis.” European Journal of Gastroenterology and Hepatology 30(7):779–85. doi: 10.1097/MEG.0000000000001109.
11 Shi, Lei, Dan Wu, Lei Wei, Suxia Liu, Peng Zhao, Bo Tu, Yangxin Xie, Yanan Liu, Xinhua Wang, Liying Liu, Xin Zhang, Zhe Xu, Fusheng Wang, and Enqiang Qin. 2017. “Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis in China: Comparative Microbiology and Therapeutic Implications.” Scientific Reports 7(April):1–7. doi: 10.1038/srep46025.
12 Fouad, T. R., Abdelsameea, E., & Elsabaawy, M. (2019). Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis. 49(3), 189–192. https://doi.org/10.1177/0049475519830265
13. Singal AK, Salameh H and Kamath PS. Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States. Aliment Pharmacol Ther 2014; 40: 105–112.
14 . Barreales M and Ferna´ ndez I. Spontaneous bacterial peritonitis. Rev Esp Enferm Dig 2011; 103: 255–263.
15 . Kaymakoglu S, Eraksoy H, Okten A, et al. Spontaneous ascitic infection in different cirrhotic groups: prevalence, risk factors and the efficacy of cefotaxime therapy. Eur J Gastroenterol Hepatol 1997; 9: 71–76.
16 . Cheong HS, Kang CI, Lee JA, et al. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis Off Publ Infect Dis Soc Am 2009; 48: 1230–1236.
17 . Tandon P and Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26–42.
18 . Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil mlipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033–1043.
19 . Berger T, Togawa A, Duncan GS, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to E. coli infection but not to ischemia reperfusion injury. Proc
Natl Acad Sci USA 2006; 103: 1834–1839.
20 . Cullaro G, Kim G, Pereira MR, et al. ascites neutrophil gelatinase-associated lipocalin identifies spontaneous bacterial peritonitis and predicts mortality in
hospitalized patients with cirrhosis. Dig Dis Sci 2017; 62: 3487–3494.
21 . Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268(14):10425-10432.
22 Bagshaw SM, Bennett M, Haase M, Haase Fielitz A, Egi M, Morimatsu H, et al.(2010):Plasma and urine neutrophil gelatinase associated lipocalin in septic versus non septic acute kidney injury in critical illness. Intensive Care Med 2010; 36:452–461.
23 Nasioudis D and Witkin SS (2015): Neutrophil gelatinase associated lipocalin and Innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
24 Ghoniema EM, Abd El Aziza AM, Abd El Motelba TM, Salama AA, and El Gazzara HM (2017): The value of lipocalin 2 as a predictive biomarker of bacterial infection in hepatic patients.Menoufia Medical Journal, Volume 30 | Number 4 | October-December 2017[Downloaded free from http://www.mmj.eg.net on Friday, April 12, 2019, IP: 197.56.184.94
25 Behairy BE, Salama EI, Allam AA, Ali MA and Abd Elaziz AM (2011):Lipocalin-2 as a Marker of Bacterial Infections in Chronic Liver Disease: A Study in Egyptian Children THE EGYPTIAN JOURNAL OF IMMUNOLOGY Vol. 18 (2), 2011 Page: 31-36.
26 Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917–921.
27 . Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. BBA Rev Cancer. 2012;1826:129–169.
28 Yilmaz A, Sevketoglu E, Gedikbasi A, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24:2387–2392.
29 . Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci. 2012;57:2362–2370. 11. Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
30 Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
31 Piano S, Brocca A, Mareso S, Angeli P. Infections complicating cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2018;38 (Suppl 1):126-33.
32 Fiore M, Maraolo AE, Gentile I, Borgia,G. Leone,S. and Sansone,p. et al. (2017).Current concepts and future strategies in the antimicrobial therapy of emerging gram-positive spontaneous bacterial peritonitis. World J Hepatol. 9(30):1166–1175
33 Acevedo J. Multiresistant bacterial infections in liver cirrhosis: clinical impact and new empirical antibiotic treatment policies. World J Hepatol.2015;7(7):916–921.
34 Abdel Salam, F., El-Toukhy, N., El- kharbotly, E., Mohamed, M., & Ameen, S. (2022). Serum Endocan Levels In Patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.118948.1538
35 ALMEIDA, P. R. L. de, LEÃO, G. S., GONÇALVES, C. D. G., PICON, R. V., & TOVO, C. V. (2018). Impact of Microbiological Changes on Spontaneous Bacterial Peritonitis in Three Different Periods Over 17 Years. Arquivos de Gastroenterologia, 55(1): 23–27.
36 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
37 Fuursted K SL, Hansen F, Dam K, Bojer MS, Hammerum A et al. Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo- beta-lactamase-1 (NDM-1). Microbes and Infection. 2012;14(2):155-158.
38 Wu CC, Wang CK, Chen YC, Lin TH, Jinn TR, Lin CT. IscR regulation of capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. PLoS One. 2014;9(9):e107812.
39 Holden VI, Bachman MA. Diverging roles of bacterial siderophores during infection. Metallomics. 2015;7(6):986-995.
40 S. Naga, I., Ghazal, A., S. Alomari, S., & Gaballah, A. (2021). Detection of Biofilm and Siderophore Encoding Genes Implicated in the Pathogenesis of Klebsiella pneumoniae Isolated from Different Clinical Specimens. Egyptian Journal of Medical Microbiology, 30(1), 101–108. https://doi.org/10.51429/ejmm30113
41 Wilson BR, Bogdan AR ,Miyazawa M, Hashimoto K, and Tsuji Y (2016): Siderophores in Iron Metabolism: From Mechanism to Therapy Potential . Trends Mol Med. 2016 December ; 22(12): 1077–1090. doi:10.1016/j.molmed.2016.10.005
42 Chon YE, Kim SU, Lee CK, Park JY, Kim DY, Han KH, et al. Community-acquired vs. nosocomial spontaneous bacterial peritonitis in patients with liver cirrhosis.Hepato-gastroenterology. 2014;61(136):2283-90.
43 Piano S, Singh V, Caraceni P, Maiwall R, Alessandria C, Fernandez J, et al. Epidemiology, predictors and outcomes of multi drug resistant (MDR) bacterial infections in patients with cirrhosis across the world. Final results of the "Global study". Digestive and Liver Disease. 2018;50(1):2-3.
44 Liu, J., Gao, Y., Wang, X., Qian, Z., Chen, J., Huang, Y., & Meng, Z. (2020). Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis : Multidrug-Resistant Pathogens and Antibiotic Strategies. 61(2), 145–153.
45 Alexopoulou, A., Vasilieva, L., Agiasotelli, D., Siranidi, K., Pouriki, S., Tsiriga, A., Toutouza, M., Dourakis, S. P., Alexopoulou, A., Vasilieva, L., & Agiasotelli, D. (2016). Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. 22(15), 4049–4056. https://doi.org/10.3748/wjg.v22.i15.4049
46 Liu H, Zhu P, Nie C, Ye Q, Gao Y, Liu H, Pang G, Han T. The value of ascitic neutrophil gelatinase-associated lipocalin in decompensated liver cirrhosis with spontaneous bacterial peritonitis. J Clin Lab Anal. 2020 Jun;34(6):e23247. doi: 10.1002/jcla.23247. Epub 2020 Feb 26. PMID: 32100329; PMCID: PMC7307354.
47 pimentel R, Leitão J, Gregório C, Santos L, Carvalho A, Figueiredo P: Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Shift in the Microbial Pattern? A Retrospective Analysis. GE Port J Gastroenterol 2022;29:256-266. doi: 10.1159/000518585
48 Hackman, Henry Kwadwo, George Osei-adjei, Andrew Gordon, Emmanuel Laryea, and Solomon Quaye. 2013. “The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates in Escherichia Coli and Klebsiella The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates .” (July 2014).
49 Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH. Global Dissemination of Carbapenemase-Producing 384 Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods. Front 385 Microbiol. 2016;7:895. Published 2016 Jun 13. doi:10.3389/fmicb.2016.00895.
50 Maniatis T., Fritsch E.F., Sambrook J. (1982) Molecular clo- ning: a laboratory manual. Cold Spring Harbor Lab. Press, New York.
51 Khazaal, M. T., El-Hendawy, H. H., Mabrouk, M. I., Faraag, A. H. I., & Bakkar, M. R. (2022). Antibiotic resistance and siderophores production by clinical Escherichia coli strains. Biotechnologia, 103(2), 169–184. https://doi.org/10.5114/bta.2022.116211
52 Kamath P, Kim W (2007): Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology,45:797-805.
53. Ascione T, Di Flumeri G, Boccia G, De Caro F. Infections in patients affected by liver cirrhosis: an update. Infez Med. 2017;25(2):91-99.
54. Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK: Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010, 139:1246-56, 1256.e1-5. 10.1053/j.gastro.2010.06.019
55. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis. 2001;33:41–48.
56. Yousef MM, Amer AI, M. Zidan A, A. Amer F, M. ElsaidTash R. Spontaneous Bacterial Peritonitis in the Medical Intensive Care Unit of a University Hospital in Egypt: Frequency, Bacteriological Profile, Risk Factors and Outcomes. The International Arabic Journal of Antimicrobial Agents. 2016;6(2):5-14.
57. Salem AM, Eliwa HM, El-saeed NH. Prevalence and characteristics of spontaneous bacterial peritonitis in hospitalized patients with ascites due to liver cirrhosis [Master thesis]. Faculty of Medicine: Cairo University; 2008.
58. Zaki MES, El Shabrawy WO, El-Eshmawy MM, Eletreby SA. The high prevalence of Listeria monocytogenes peritonitis in cirrhotic patients of an Egyptian Medical Center. Journal of Infection and Public Health. 2011;4(4):211-6.
59. El-Amin H, Sabry AMM, Ahmed RE, Makhlouf NA. Types and microbiological spectrum of infections in patients with cirrhosis: A single-centre experience in Upper Egypt. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2017;18(3):159-64.
60. Muhammad T, Shereen AA, Mabrouk R, Abdallah A. Frequency of Spontaneous Bacterial Peritonitis in Patients of Liver Cirrhosis with Ascites at Tanta University Hospitals. The Medical Journal of Cairo University. 2019;87(March):147-52.
61. Makhlouf NA, Ghaliony MA, El-Dakhli SA, Elfatth AMA, Mahmoud AA. Spontaneous Bacterial Peritonitis among Cirrhotic Patients in Upper Egypt: Clinical and Bacterial Profiles. Journal of Gastroenterology and Hepatology Research. 2019;8(6):3014-9.
62. Kamal SM, Abdelhakam SM, Massoud YM, El Hafeez A, El Aziz KA, Kamal HA. Clinical Profile of patients with Ascitic Fluid Infection at Ain Shams University Hospitals. The Egyptian Journal of Hospital Medicine. 2018;72(9):5241-50.
63. Metwally K, Fouad T, Assem M, Abdelsameea E, Yousery M. Predictors of Spontaneous Bacterial Peritonitis in Patients with Cirrhotic Ascites. Journal of clinical and translational hepatology. 2018;6(4):372-6.
64. Mir M, Rather M, Kadla S, Wani Z, Shah N, editors. Study of etiological profile and resistance pattern of spontaneous bacterial peritonitis in chronicBenha medical journal, vol. 39, issue 2, 2022 664 liver disease. Journal of gastroenterology and hepatology; 2019: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
65. Goel S, Pandey PT, Kumar A, Kumar N, Arora DK, Singh A. Clinico-bacteriological profile of spontaneous bacterial peritonitis in cirrhosis of liver with ascites. International Journal of Research in Medical Sciences. 2019;7(11):4256-60.
66. Oladimeji A, Temi A, Adekunle A et al. (2013): Prevalence of spontaneous bacterial peritonitis in liver cirrhosis with ascites. The Pan African Medical Journal, 15: 128-32.
67 Abd-Elsalam, F., Zeinelabedin, M., Abdelrahman, S., & Gabal, H. (2022). Bacteriological Profile and Antimicrobial Resistance in Ascitic Fluid of Patients with Community Acquired and Nosocomial Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.97727.1490
68 Hafez, M. Z., Abdallah, H., Abdallah, M., Khairy, K., & Abdellatif, K. (2020). Prevalence of Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Ascites and Its Pattern in Aswan University Hospital. 81(October), 1444–1448.
69 Pimentel, R., & Santos, L. (2022). Spontaneous Bacterial Peritonitis in Cirrhotic Patients : A Shift in the Microbial Pattern ? A Retrospective Analysis. 256–266. https://doi.org/10.1159/000518585
70 Taherifard, E., Hosseini-asl, M. K., & Mosayebi, M. A. (2021). Distribution and antimicrobial resistance pattern of pathogens causing spontaneous bacterial peritonitis in patients with cirrhosis at Namazi hospital , southern Iran. 13(3), 425–426.
71 Mohammed A. R.(2018). Plasma Neutrophil Gelatinase-Associated Lipocalin as a biomarker for the diagnosis of hepatorenal syndrome and spontaneous bacterial peritonitis in cirrhotic patients .
72 Ximenes RO, Farias AQ, Helou CM. Early predictors of acute kidney injury in patients with cirrhosis and bacterial infection: urinary neutrophil gelatinase‑associated lipocalin and cardiac output as reliable tools. Kidney Res Clin Pract 2015; 34:140–145.
73 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
74 Metwally, K., Fouad, T., Assem, M., Abdelsameea, E., and Yousery, M. (2018). Predictors of spontaneous bacterial peritonitis in patients with cirrhotic ascites. Journal of Clinical and Translational Hepatology; 6(4): 1–5.
75 Hamed, A. A., Morsy, K. H., & Mohammad, A. N. (2022). Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients. 88(July), 4117–4120.
76. Lee SS, Min HJ, Choi JY, et al. Usefulness of ascitic fluid lactoferrin levels in patients with liver cirrhosis. BMC Gastroenterol.2016;16(1):132.
77 Nasioudis D, Witkin SS. Neutrophil gelatinase‑associated lipocalin and innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
78 Saha, M., Sarkar, S., Sarkar, B., & Sharma, B. K. (2016). Microbial siderophores and their potential applications : a review. 3984–3999. https://doi.org/10.1007/s11356-015-4294-0
79 Calhau, V. (2014). Antimicrobial resistance determinants among Escherichia coli and Klebsiella spp. Tesis, Universira, 151.
80 Ellermann M, Arthur JC. Siderophore-mediated iron acquisition and modulation of host-bacterial interactions. Free Radic Biol Med. 2017;105:68-78.
81 Wasfi, R., Elkhatib, W. F., & Ashour, H. M. (2016). Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals. Scientific Reports, 6(December), 1–11. https://doi.org/10.1038/srep38929
82 Kumar, R., Das, A., Gaur, M., & Pattanayak, A. (2019). Genotypic validation of extended-spectrum β -lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital. Pathogens and Global Health, 113(7), 315–321. https://doi.org/10.1080/20477724.2019.1705020
83 Shakib, P., Kalani, M. T., Ramazanzadeh, R., & Rouhi, S. (2018). Molecular detection of virulence genes in Klebsiella Pneumoniae clinical isolates from Kurdistan Province , Iran Biomed Press. 5(8), 2581–2589.
84 Abduljabbar, A., Aljanaby, J., Hassan, A., & Alhasani, A. (2016). Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. 10(22), 829–843. https://doi.org/10.5897/AJMR2016.8051
85 .Fertas-Aissani R, Messai Y, Alouache S, Bakour R (2013). Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumonia strains isolated from different clinical specimens. Pathol. Biol. 61(5):209-216.
86 KUŞ H, ARSLAN, U., DAĞI, H. T., & FINDIK, D. Hastane Enfeksiyonu Etkeni Klebsiella pneumoniae İzolatlarında Çeşitli Virülans Faktörlerinin Araştırılması. Mikrobiyol Bul. 2017;51(4):329-339.
87 Aljanaby AAJ, & Alhasani, A. H. A. . Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. African Journal of Microbiology Research. 2016;10(22):829-843.
88 Daoud N., Abou Sulaiman A.and Al Kwatli K.H. VIRULENCE DETERMINANTS OF ESCHERICHIA COLI STRAINS HOSPITALS IN SYRIA. (2020). Bulletin of Pharmaceutical Sciences .Assiut University .43(2), 255–264.
89 J. Sarowska, B. Futoma-Koloch, A. Jama- Kmiecik, M. Frej-Madrzak, M. Ksiazczyk, G. Bugla-Ploskonska, et al., "Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports", Gut Pathogens, 11
90 Matin, Z., Clin, A., Antimicrob, M., Matin, F. Z., Rezatofighi, S. E., & Ardakani, M. R. (2021). Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo beta lactamase producing isolates. Annals of Clinical Microbiology and Antimicrobials, 4, 1–13. https://doi.org/10.1186/s12941-021-00457-4
91 Candan, E. D., & Aksöz, N. (2017). Escherichia Coli : Characteristics of Carbapenem Resistance and Virulence Factors. 60(December), 1–12.
92 Cholongitas E, Burroughs A (2012): The evolution in the prioritization for liver transplantation. Ann Gastroenterol., 25(1):6-13.
93 Elzouki, A., Hamad, A., Almasri, H., Ata, M., & Ashour, A. (2021). Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients Patient characteristics and outcomes. 13(10), 8–13. https://doi.org/10.7759/cureus.18999
94 Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflam- mation and cancer. BBA Rev Cancer. 2012;1826:129–169.
95 Wong, Y. J., Kalki, R. C., Lin, K. W., Kumar, R., Tan, J., Teo, E. K., & Li, J. W. (2020). Short- and long-term predictors of spontaneous bacterial peritonitis in Singapore. 61(8), 419–425.
96 Ning, N., Li, T., Zhang, J., Qu, F., Huang, J., Liu, X., Li, Z., Geng, W., & Fu, J. (2018). Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis. 1–11.
97 Rastegar, S., Moradi, M., Kalantar-Neyestanaki, D., Dehdasht, A. G., & Hosseini-Nave, H. (2021). Virulence factors, capsular serotypes and antimicrobial resistance of hypervirulent klebsiella pneumoniae and classical klebsiella pneumoniae in Southeast Iran. Infection and Chemotherapy, 53(1), 345–352. https://doi.org/10.3947/IC.2019.0027
98 Allred BE, Correnti C, Clifton MC, Strong RK, Raymond KN.2013 Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae. ACS Chem Biol 2013; 8:1882–7.
99 Hider RC, Kong X.2010 Chemistry and biology of siderophores. Nat Prod Rep 2010;27:637–57.
100 Crosa, J.H.;Walsh, C.T.2002 Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria. Microbiol. Mol. Biol. Rev. 2002, 66, 223–249.
101 Fischbach, M.A.; Lin, H.; Zhou, L.; Yu, Y.; Abergel, R.J.; Liu, D.R.; Raymond, K.N.;Wanner, B.L.; Strong, R.K.;Walsh, C.T.; et al.2006The Pathogen-Associated IroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2. Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507.
102 Garénaux, A.; Caza, M.; Dozois, C.M.2011 The Ins and Outs of Siderophore Mediated Iron Uptake by Extra-Intestinal PathogenicEscherichia coli. Vet. Microbiol. 2011, 153, 89–98.
103 Dauner M, Skerra A 2020. Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy. Chembiochem. 2020 Mar 2;21(5):601-606. doi: 10.1002/cbic.201900564. Epub 2019 Dec 13. PMID: 31613035; PMCID: PMC7079049.
104 a) K. Hantke, G. Nicholson, W. Rabsch, G. Winkelmann, Proc. Natl. Acad. Sci. USA 2003, 100,3677–3682;b)B.Bister,D.Bischoff, G. J. Nicholson, M. Valdebenito, K. Schneider,G.Winkelmann,K.Hantke,R.D.Süssmuth, BioMetals 2004, 17,471–481
105 a) M. A. Fischbach, H. Lin, L. Zhou, Y. Yu,R.J.Abergel, D. R. Liu, K. N. Raymond, B. L. Wanner,R.K.Strong, C. T. Walsh, A. Aderem, K. D. Smith, Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507;b)M.A.Fischbach, H. Lin, D. R. Liu, C. T. Walsh, Nat. Chem. Biol. 2006, 2,132–138.ChemBioChem
106 Guo, B., Wang, Q., Li, J., Gan, Z., Zhang, X., Wang, Y., & Du, H. (2017). Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection. 8(39), 65386–65396.
107 Golonka R, Yeoh BS, Vijay-Kumar M. The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity. J Innate Immun. 2019;11(3):249-262. doi: 10.1159/000494627. Epub 2019 Jan 3. PMID: 30605903; PMCID: PMC6487204.
108 Hider RC, Kong X. Chemistry and biology of siderophores. Nat Prod Rep. 2010 May; 27(5): 637–57.
109 Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. (2019). Journal of Structural Biology : X Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology: X, 2(May), 100008. https://doi.org/10.1016/j.yjsbx.2019.100008
110 Holden, V. I., Lenio, S., Kuick, R., Ramakrishnan, S. K., Shah, Y. M., & Bachman, A. (2014). Bacterial Siderophores That Evade or Overwhelm Lipocalin 2 Induce Hypoxia Inducible Factor 1 ␣ and Proinflammatory Cytokine Secretion in Cultured Respiratory Epithelial Cells. 82(9), 3826–3836. https://doi.org/10.1128/IAI.01849-14
111 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
112 Munoz-Price, L. S. & Quinn, J. P. The Spread of Klebsiella pneumoniae Carbapenemases: A Tale of Strains, Plasmids, and Transposons. Clinical Infectious Diseases 49, 1739–1741, doi: 10.1086/648078 (2009).
113 Falagas, M. E. & Karageorgopoulos, D. E. Extended-spectrum beta-lactamase-producing organisms. J Hosp Infect 73, 345–354, doi: 10.1016/j.jhin.2009.02.021 (2009).
114 Miro, E. et al. Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates. J Antimicrob Chemother 65, 661–665, doi: 10.1093/jac/dkp504 (2010)
115 Hennequin C., Robin F. (2016) Correlation between antimi- crobial resistance and virulence in Klebsiella pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis. 35(3): 333–341. https://doi.org/10.1007/s10096-015-2559-7; https://www. ncbi.nlm.nih.gov/pubmed/26718943
116 Kallau NHG, Wibawan IWT, Lukman DW, Sudarwanto MB. Detection of multi-drug resistant (MDR) Escherichia coli and tet gene prevalence at a pig farm in Kupang, Indonesia. J Adv Vet Anim Res. 2018;5(4):388–396. doi:10.5455/javar.2018.e289
117 Ibrahim, R. A. (2020). Prevalence of Virulence Genes and Their Association with Antimicrobial Resistance Among Pathogenic E . coli Isolated from Egyptian Patients with Different Clinical Infections. 1221–1236.
118 Cepas, V., & Soto, S. M. (2020). Relationship between Virulence and Resistance among Gram-Negative Bacteria. 1–11.
119 Karam MRA, Habibi M, Bouzari S. Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran. Osong Public Health Res Perspect. 2018 Oct;9(5):217-224. doi: 10.24171/j.phrp.2018.9.5.02. PMID: 30402376; PMCID: PMC6202021.
120 Sundaresan, A. K., Vincent, K., Babu, G., Mohan, M., & Ramakrishnan, J. (2022). Journal of Global Antimicrobial Resistance Association of sequence types , antimicrobial resistance and virulence genes in Indian isolates of Klebsiella pneumoniae : A comparative genomics study. Journal of Global Antimicrobial Resistance, 30, 431–441. https://doi.org/10.1016/j.jgar.2022.05.006
121 Popoiag, R. E., Panaitescu, E., Suceveanu, A. I., Suceveanu, A. P., Micu, S. I., Mazilu, L., Parepa, I., Voinea, F., Costea, D. O., Enache, F., & Fierbințeanu-braticevici, C. (2021). Spontaneous bacterial peritonitis mortality trends of cirrhotic patients in the last decade in Constanta County. 1–6. https://doi.org/10.3892/etm.2021.10164
122 Kim JJ, Tsukamoto MM, Mathur AK, Ghomri YM, Hou LA, Sheibani S, Runyon BA: Delayed paracentesis is associated with increased in-hospital mortality in patients
123 Ding, X., Yu, Y., Chen, M., Wang, C., Kang, Y., & Lou, J. (2019). Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients : community-acquired versus nosocomial infections. 1–8.
124 Cheong HS, Kang CI, Lee JA, Moon SY, Joung MK, Chung DR, Koh KC, Lee NY, Song JH, Peck KR. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis. 2009;48(9):1230–6.
125 Fernández J, Navasa M, Gómez J, Colmenero J, Vila J, Arroyo V, Rodés J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology. 2002;35(1):140–8.
126 Song JY, Jung SJ, Park CW, Sohn JW, Kim WJ, Kim MJ, Cheong HJ.Prognostic significance of infection acquisition sites in spontaneous bacterial peritonitis: nosocomial versus community acquired. J Korean Med Sci. 2006;21(4):666–71.
127 Chaulk J, Carbonneau M, Qamar H, Keough A, Chang HJ, Ma M, Kumar D, Tandon P. Third-generation cephalosporin-resistant spontaneous bacterial peritonitis: a single-Centre experience and summary of existing studies. Can J Gastroenterol Hepatol. 2014;28(2):83–8.
128 Park YH, Lee HC, Song HG, Jung S, Ryu SH, Shin JW, Chung YH, Lee YS, Suh DJ. Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea. J Gastroenterol Hepatol. 2003;18(8):927–33.
129 Heo J, Seo YS, Yim HJ, Hahn T, Park SH, Ahn SH, Park JY, Park JY, Kim MY, Park SK, et al. Clinical features and prognosis of spontaneous bacterial peritonitis in Korean patients with liver cirrhosis: a multicenter retrospective study. Gut Liver. 2009;3(3):197–204.
130 Macnaughtan J, Jalan R. Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis. Am J Gastroenterol 2015; 110:1399-410; quiz 1411.
131 Bhattacharya, C., Das-mondal, M., & Gupta, D. (2019). Annals of Hepatology Infection in cirrhosis : A prospective study. Annals of Hepatology, 18(6), 862–868. https://doi.org/10.1016/j.aohep.2019.07.010
1 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
2 Elsherif, A. A., Eldahshan, M. A., Hussein, M. S., & Mohamed, A. M. (2016). Asymptomatic Spontaneous Bacterial Peritonitis in Adult Egyptian Patients with Decompensated Liver Cirrhosis: A Prospective Cohort Study. International Journal of Advanced Biomedicine, 1(1): 5–9.
3 Albillos A, Lario M, Alvarez-Mon M. Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. J Hepatol. (2014) 61:1385–96. doi: 10.1016/j.jhep.2014.08.010
4 Bunchorntavakul C, Chamroonkul N, Chavalitdhamrong D. Bacterial infections in cirrhosis: A critical review and practical guidance. World J Hepatol. (2016) 8:307–21. doi: 10.4254/wjh.v8.i6.307
5 Alexandre dA. Akin criteria as a predictor of mortality in cirrhotic patients after spontaneous bacterial peritonitis. Ann Hepatol. (2014) 13:390−5. doi: 10.1016S1665-2681(19)30870-1
6 Iliaz R, Ozpolat T, Baran B, Demir K, Kaymakoglu S, Besisik F, et al. Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers. Eur JGastroen Hepat. (2018) 30:786– 91. doi: 10.1097/MEG.0000000000001111
7 Schwabl P, Bucsics T, Soucek K, Mandorfer M, Bota S. Blacky A. Reiberger T Risk factors for development of spontaneous bacterial peritonitis and subsequent mortality in cirrhotic patients with ascites. Liver Int. (2015) 35:2121–8. doi: 10.1111/liv.12795
8 Terg R, Gadano A, Cartier M, Casciato P, Lucero R. Munoz A. Abecasis R Serum creatinine and bilirubin predict renal failure and mortality in patients with spontaneous bacterial peritonitis: a retrospective study. Liver Int. (2009) 29:415–9. doi: 10.1111/j.1478-3231.2008.01877.x
9 Xiang, Shoushu, Juntao Tan, Chao Tan, Qian Xu, Yuanjiu Wen, Tiantian Wang, Chen Yang, and Wenlong Zhao. 2022. “Establishment and Validation of a Non-Invasive Diagnostic Nomogram to Identify Spontaneous Bacterial Peritonitis in Patients With Decompensated Cirrhosis.” Frontiers in Medicine 8(January):1–10. doi: 10.3389/fmed.2021.797363.
10 Abdel-Razik, Ahmed, Waleed Eldars, Rania Elhelaly, Ahmed A. Eldeeb, Mostafa Abdelsalam, Niveen El-Wakeel, and Alsaid Aboulmagd. 2018. “Homocysteine: A New Diagnostic Marker in Spontaneous Bacterial Peritonitis.” European Journal of Gastroenterology and Hepatology 30(7):779–85. doi: 10.1097/MEG.0000000000001109.
11 Shi, Lei, Dan Wu, Lei Wei, Suxia Liu, Peng Zhao, Bo Tu, Yangxin Xie, Yanan Liu, Xinhua Wang, Liying Liu, Xin Zhang, Zhe Xu, Fusheng Wang, and Enqiang Qin. 2017. “Nosocomial and Community-Acquired Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis in China: Comparative Microbiology and Therapeutic Implications.” Scientific Reports 7(April):1–7. doi: 10.1038/srep46025.
12 Fouad, T. R., Abdelsameea, E., & Elsabaawy, M. (2019). Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis. 49(3), 189–192. https://doi.org/10.1177/0049475519830265
13. Singal AK, Salameh H and Kamath PS. Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States. Aliment Pharmacol Ther 2014; 40: 105–112.
14 . Barreales M and Ferna´ ndez I. Spontaneous bacterial peritonitis. Rev Esp Enferm Dig 2011; 103: 255–263.
15 . Kaymakoglu S, Eraksoy H, Okten A, et al. Spontaneous ascitic infection in different cirrhotic groups: prevalence, risk factors and the efficacy of cefotaxime therapy. Eur J Gastroenterol Hepatol 1997; 9: 71–76.
16 . Cheong HS, Kang CI, Lee JA, et al. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis Off Publ Infect Dis Soc Am 2009; 48: 1230–1236.
17 . Tandon P and Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26–42.
18 . Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil mlipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033–1043.
19 . Berger T, Togawa A, Duncan GS, et al. Lipocalin 2-deficient mice exhibit increased sensitivity to E. coli infection but not to ischemia reperfusion injury. Proc
Natl Acad Sci USA 2006; 103: 1834–1839.
20 . Cullaro G, Kim G, Pereira MR, et al. ascites neutrophil gelatinase-associated lipocalin identifies spontaneous bacterial peritonitis and predicts mortality in
hospitalized patients with cirrhosis. Dig Dis Sci 2017; 62: 3487–3494.
21 . Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem. 1993;268(14):10425-10432.
22 Bagshaw SM, Bennett M, Haase M, Haase Fielitz A, Egi M, Morimatsu H, et al.(2010):Plasma and urine neutrophil gelatinase associated lipocalin in septic versus non septic acute kidney injury in critical illness. Intensive Care Med 2010; 36:452–461.
23 Nasioudis D and Witkin SS (2015): Neutrophil gelatinase associated lipocalin and Innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
24 Ghoniema EM, Abd El Aziza AM, Abd El Motelba TM, Salama AA, and El Gazzara HM (2017): The value of lipocalin 2 as a predictive biomarker of bacterial infection in hepatic patients.Menoufia Medical Journal, Volume 30 | Number 4 | October-December 2017[Downloaded free from http://www.mmj.eg.net on Friday, April 12, 2019, IP: 197.56.184.94
25 Behairy BE, Salama EI, Allam AA, Ali MA and Abd Elaziz AM (2011):Lipocalin-2 as a Marker of Bacterial Infections in Chronic Liver Disease: A Study in Egyptian Children THE EGYPTIAN JOURNAL OF IMMUNOLOGY Vol. 18 (2), 2011 Page: 31-36.
26 Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432(7019):917–921.
27 . Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. BBA Rev Cancer. 2012;1826:129–169.
28 Yilmaz A, Sevketoglu E, Gedikbasi A, et al. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatr Nephrol. 2009;24:2387–2392.
29 . Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis. Dig Dis Sci. 2012;57:2362–2370. 11. Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
30 Roth GA, Nickl S, Lebherz-Eichinger D, et al. Lipocalin-2 serum levels are increased in acute hepatic failure. TPS. 2013;45:241–244.
31 Piano S, Brocca A, Mareso S, Angeli P. Infections complicating cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2018;38 (Suppl 1):126-33.
32 Fiore M, Maraolo AE, Gentile I, Borgia,G. Leone,S. and Sansone,p. et al. (2017).Current concepts and future strategies in the antimicrobial therapy of emerging gram-positive spontaneous bacterial peritonitis. World J Hepatol. 9(30):1166–1175
33 Acevedo J. Multiresistant bacterial infections in liver cirrhosis: clinical impact and new empirical antibiotic treatment policies. World J Hepatol.2015;7(7):916–921.
34 Abdel Salam, F., El-Toukhy, N., El- kharbotly, E., Mohamed, M., & Ameen, S. (2022). Serum Endocan Levels In Patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.118948.1538
35 ALMEIDA, P. R. L. de, LEÃO, G. S., GONÇALVES, C. D. G., PICON, R. V., & TOVO, C. V. (2018). Impact of Microbiological Changes on Spontaneous Bacterial Peritonitis in Three Different Periods Over 17 Years. Arquivos de Gastroenterologia, 55(1): 23–27.
36 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
37 Fuursted K SL, Hansen F, Dam K, Bojer MS, Hammerum A et al. Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo- beta-lactamase-1 (NDM-1). Microbes and Infection. 2012;14(2):155-158.
38 Wu CC, Wang CK, Chen YC, Lin TH, Jinn TR, Lin CT. IscR regulation of capsular polysaccharide biosynthesis and iron-acquisition systems in Klebsiella pneumoniae CG43. PLoS One. 2014;9(9):e107812.
39 Holden VI, Bachman MA. Diverging roles of bacterial siderophores during infection. Metallomics. 2015;7(6):986-995.
40 S. Naga, I., Ghazal, A., S. Alomari, S., & Gaballah, A. (2021). Detection of Biofilm and Siderophore Encoding Genes Implicated in the Pathogenesis of Klebsiella pneumoniae Isolated from Different Clinical Specimens. Egyptian Journal of Medical Microbiology, 30(1), 101–108. https://doi.org/10.51429/ejmm30113
41 Wilson BR, Bogdan AR ,Miyazawa M, Hashimoto K, and Tsuji Y (2016): Siderophores in Iron Metabolism: From Mechanism to Therapy Potential . Trends Mol Med. 2016 December ; 22(12): 1077–1090. doi:10.1016/j.molmed.2016.10.005
42 Chon YE, Kim SU, Lee CK, Park JY, Kim DY, Han KH, et al. Community-acquired vs. nosocomial spontaneous bacterial peritonitis in patients with liver cirrhosis.Hepato-gastroenterology. 2014;61(136):2283-90.
43 Piano S, Singh V, Caraceni P, Maiwall R, Alessandria C, Fernandez J, et al. Epidemiology, predictors and outcomes of multi drug resistant (MDR) bacterial infections in patients with cirrhosis across the world. Final results of the "Global study". Digestive and Liver Disease. 2018;50(1):2-3.
44 Liu, J., Gao, Y., Wang, X., Qian, Z., Chen, J., Huang, Y., & Meng, Z. (2020). Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis : Multidrug-Resistant Pathogens and Antibiotic Strategies. 61(2), 145–153.
45 Alexopoulou, A., Vasilieva, L., Agiasotelli, D., Siranidi, K., Pouriki, S., Tsiriga, A., Toutouza, M., Dourakis, S. P., Alexopoulou, A., Vasilieva, L., & Agiasotelli, D. (2016). Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia. 22(15), 4049–4056. https://doi.org/10.3748/wjg.v22.i15.4049
46 Liu H, Zhu P, Nie C, Ye Q, Gao Y, Liu H, Pang G, Han T. The value of ascitic neutrophil gelatinase-associated lipocalin in decompensated liver cirrhosis with spontaneous bacterial peritonitis. J Clin Lab Anal. 2020 Jun;34(6):e23247. doi: 10.1002/jcla.23247. Epub 2020 Feb 26. PMID: 32100329; PMCID: PMC7307354.
47 pimentel R, Leitão J, Gregório C, Santos L, Carvalho A, Figueiredo P: Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Shift in the Microbial Pattern? A Retrospective Analysis. GE Port J Gastroenterol 2022;29:256-266. doi: 10.1159/000518585
48 Hackman, Henry Kwadwo, George Osei-adjei, Andrew Gordon, Emmanuel Laryea, and Solomon Quaye. 2013. “The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates in Escherichia Coli and Klebsiella The Reliability of Using Vitek 2 Compact System to Detect Extended-Spectrum Beta-Lactamase-Producing Isolates .” (July 2014).
49 Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH. Global Dissemination of Carbapenemase-Producing 384 Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods. Front 385 Microbiol. 2016;7:895. Published 2016 Jun 13. doi:10.3389/fmicb.2016.00895.
50 Maniatis T., Fritsch E.F., Sambrook J. (1982) Molecular clo- ning: a laboratory manual. Cold Spring Harbor Lab. Press, New York.
51 Khazaal, M. T., El-Hendawy, H. H., Mabrouk, M. I., Faraag, A. H. I., & Bakkar, M. R. (2022). Antibiotic resistance and siderophores production by clinical Escherichia coli strains. Biotechnologia, 103(2), 169–184. https://doi.org/10.5114/bta.2022.116211
52 Kamath P, Kim W (2007): Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology,45:797-805.
53. Ascione T, Di Flumeri G, Boccia G, De Caro F. Infections in patients affected by liver cirrhosis: an update. Infez Med. 2017;25(2):91-99.
54. Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK: Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010, 139:1246-56, 1256.e1-5. 10.1053/j.gastro.2010.06.019
55. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis. 2001;33:41–48.
56. Yousef MM, Amer AI, M. Zidan A, A. Amer F, M. ElsaidTash R. Spontaneous Bacterial Peritonitis in the Medical Intensive Care Unit of a University Hospital in Egypt: Frequency, Bacteriological Profile, Risk Factors and Outcomes. The International Arabic Journal of Antimicrobial Agents. 2016;6(2):5-14.
57. Salem AM, Eliwa HM, El-saeed NH. Prevalence and characteristics of spontaneous bacterial peritonitis in hospitalized patients with ascites due to liver cirrhosis [Master thesis]. Faculty of Medicine: Cairo University; 2008.
58. Zaki MES, El Shabrawy WO, El-Eshmawy MM, Eletreby SA. The high prevalence of Listeria monocytogenes peritonitis in cirrhotic patients of an Egyptian Medical Center. Journal of Infection and Public Health. 2011;4(4):211-6.
59. El-Amin H, Sabry AMM, Ahmed RE, Makhlouf NA. Types and microbiological spectrum of infections in patients with cirrhosis: A single-centre experience in Upper Egypt. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2017;18(3):159-64.
60. Muhammad T, Shereen AA, Mabrouk R, Abdallah A. Frequency of Spontaneous Bacterial Peritonitis in Patients of Liver Cirrhosis with Ascites at Tanta University Hospitals. The Medical Journal of Cairo University. 2019;87(March):147-52.
61. Makhlouf NA, Ghaliony MA, El-Dakhli SA, Elfatth AMA, Mahmoud AA. Spontaneous Bacterial Peritonitis among Cirrhotic Patients in Upper Egypt: Clinical and Bacterial Profiles. Journal of Gastroenterology and Hepatology Research. 2019;8(6):3014-9.
62. Kamal SM, Abdelhakam SM, Massoud YM, El Hafeez A, El Aziz KA, Kamal HA. Clinical Profile of patients with Ascitic Fluid Infection at Ain Shams University Hospitals. The Egyptian Journal of Hospital Medicine. 2018;72(9):5241-50.
63. Metwally K, Fouad T, Assem M, Abdelsameea E, Yousery M. Predictors of Spontaneous Bacterial Peritonitis in Patients with Cirrhotic Ascites. Journal of clinical and translational hepatology. 2018;6(4):372-6.
64. Mir M, Rather M, Kadla S, Wani Z, Shah N, editors. Study of etiological profile and resistance pattern of spontaneous bacterial peritonitis in chronicBenha medical journal, vol. 39, issue 2, 2022 664 liver disease. Journal of gastroenterology and hepatology; 2019: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.
65. Goel S, Pandey PT, Kumar A, Kumar N, Arora DK, Singh A. Clinico-bacteriological profile of spontaneous bacterial peritonitis in cirrhosis of liver with ascites. International Journal of Research in Medical Sciences. 2019;7(11):4256-60.
66. Oladimeji A, Temi A, Adekunle A et al. (2013): Prevalence of spontaneous bacterial peritonitis in liver cirrhosis with ascites. The Pan African Medical Journal, 15: 128-32.
67 Abd-Elsalam, F., Zeinelabedin, M., Abdelrahman, S., & Gabal, H. (2022). Bacteriological Profile and Antimicrobial Resistance in Ascitic Fluid of Patients with Community Acquired and Nosocomial Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2022.97727.1490
68 Hafez, M. Z., Abdallah, H., Abdallah, M., Khairy, K., & Abdellatif, K. (2020). Prevalence of Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Ascites and Its Pattern in Aswan University Hospital. 81(October), 1444–1448.
69 Pimentel, R., & Santos, L. (2022). Spontaneous Bacterial Peritonitis in Cirrhotic Patients : A Shift in the Microbial Pattern ? A Retrospective Analysis. 256–266. https://doi.org/10.1159/000518585
70 Taherifard, E., Hosseini-asl, M. K., & Mosayebi, M. A. (2021). Distribution and antimicrobial resistance pattern of pathogens causing spontaneous bacterial peritonitis in patients with cirrhosis at Namazi hospital , southern Iran. 13(3), 425–426.
71 Mohammed A. R.(2018). Plasma Neutrophil Gelatinase-Associated Lipocalin as a biomarker for the diagnosis of hepatorenal syndrome and spontaneous bacterial peritonitis in cirrhotic patients .
72 Ximenes RO, Farias AQ, Helou CM. Early predictors of acute kidney injury in patients with cirrhosis and bacterial infection: urinary neutrophil gelatinase‑associated lipocalin and cardiac output as reliable tools. Kidney Res Clin Pract 2015; 34:140–145.
73 Biomy, H., Ramadan, N., Ameen, S., Kandil, A. E. din, & Galal, Z. (2021). Evaluation of Ascitic Fluid Neutrophil Gelatinase Associated Lipocalin in patients with Spontaneous Bacterial Peritonitis. Benha Medical Journal, 0(0), 0–0. https://doi.org/10.21608/bmfj.2021.73302.1410
74 Metwally, K., Fouad, T., Assem, M., Abdelsameea, E., and Yousery, M. (2018). Predictors of spontaneous bacterial peritonitis in patients with cirrhotic ascites. Journal of Clinical and Translational Hepatology; 6(4): 1–5.
75 Hamed, A. A., Morsy, K. H., & Mohammad, A. N. (2022). Prognostic Factors of Short-Term Mortality in Spontaneous Bacterial Peritonitis Patients. 88(July), 4117–4120.
76. Lee SS, Min HJ, Choi JY, et al. Usefulness of ascitic fluid lactoferrin levels in patients with liver cirrhosis. BMC Gastroenterol.2016;16(1):132.
77 Nasioudis D, Witkin SS. Neutrophil gelatinase‑associated lipocalin and innate immune responses to bacterial infections. Med Microbiol Immunol 2015; 204:471–479.
78 Saha, M., Sarkar, S., Sarkar, B., & Sharma, B. K. (2016). Microbial siderophores and their potential applications : a review. 3984–3999. https://doi.org/10.1007/s11356-015-4294-0
79 Calhau, V. (2014). Antimicrobial resistance determinants among Escherichia coli and Klebsiella spp. Tesis, Universira, 151.
80 Ellermann M, Arthur JC. Siderophore-mediated iron acquisition and modulation of host-bacterial interactions. Free Radic Biol Med. 2017;105:68-78.
81 Wasfi, R., Elkhatib, W. F., & Ashour, H. M. (2016). Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals. Scientific Reports, 6(December), 1–11. https://doi.org/10.1038/srep38929
82 Kumar, R., Das, A., Gaur, M., & Pattanayak, A. (2019). Genotypic validation of extended-spectrum β -lactamase and virulence factors in multidrug resistance Klebsiella pneumoniae in an Indian hospital. Pathogens and Global Health, 113(7), 315–321. https://doi.org/10.1080/20477724.2019.1705020
83 Shakib, P., Kalani, M. T., Ramazanzadeh, R., & Rouhi, S. (2018). Molecular detection of virulence genes in Klebsiella Pneumoniae clinical isolates from Kurdistan Province , Iran Biomed Press. 5(8), 2581–2589.
84 Abduljabbar, A., Aljanaby, J., Hassan, A., & Alhasani, A. (2016). Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. 10(22), 829–843. https://doi.org/10.5897/AJMR2016.8051
85 .Fertas-Aissani R, Messai Y, Alouache S, Bakour R (2013). Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumonia strains isolated from different clinical specimens. Pathol. Biol. 61(5):209-216.
86 KUŞ H, ARSLAN, U., DAĞI, H. T., & FINDIK, D. Hastane Enfeksiyonu Etkeni Klebsiella pneumoniae İzolatlarında Çeşitli Virülans Faktörlerinin Araştırılması. Mikrobiyol Bul. 2017;51(4):329-339.
87 Aljanaby AAJ, & Alhasani, A. H. A. . Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. African Journal of Microbiology Research. 2016;10(22):829-843.
88 Daoud N., Abou Sulaiman A.and Al Kwatli K.H. VIRULENCE DETERMINANTS OF ESCHERICHIA COLI STRAINS HOSPITALS IN SYRIA. (2020). Bulletin of Pharmaceutical Sciences .Assiut University .43(2), 255–264.
89 J. Sarowska, B. Futoma-Koloch, A. Jama- Kmiecik, M. Frej-Madrzak, M. Ksiazczyk, G. Bugla-Ploskonska, et al., "Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports", Gut Pathogens, 11
90 Matin, Z., Clin, A., Antimicrob, M., Matin, F. Z., Rezatofighi, S. E., & Ardakani, M. R. (2021). Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo beta lactamase producing isolates. Annals of Clinical Microbiology and Antimicrobials, 4, 1–13. https://doi.org/10.1186/s12941-021-00457-4
91 Candan, E. D., & Aksöz, N. (2017). Escherichia Coli : Characteristics of Carbapenem Resistance and Virulence Factors. 60(December), 1–12.
92 Cholongitas E, Burroughs A (2012): The evolution in the prioritization for liver transplantation. Ann Gastroenterol., 25(1):6-13.
93 Elzouki, A., Hamad, A., Almasri, H., Ata, M., & Ashour, A. (2021). Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients Patient characteristics and outcomes. 13(10), 8–13. https://doi.org/10.7759/cureus.18999
94 Chakraborty S, Kaur S, Guha S, Batra SK. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflam- mation and cancer. BBA Rev Cancer. 2012;1826:129–169.
95 Wong, Y. J., Kalki, R. C., Lin, K. W., Kumar, R., Tan, J., Teo, E. K., & Li, J. W. (2020). Short- and long-term predictors of spontaneous bacterial peritonitis in Singapore. 61(8), 419–425.
96 Ning, N., Li, T., Zhang, J., Qu, F., Huang, J., Liu, X., Li, Z., Geng, W., & Fu, J. (2018). Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis. 1–11.
97 Rastegar, S., Moradi, M., Kalantar-Neyestanaki, D., Dehdasht, A. G., & Hosseini-Nave, H. (2021). Virulence factors, capsular serotypes and antimicrobial resistance of hypervirulent klebsiella pneumoniae and classical klebsiella pneumoniae in Southeast Iran. Infection and Chemotherapy, 53(1), 345–352. https://doi.org/10.3947/IC.2019.0027
98 Allred BE, Correnti C, Clifton MC, Strong RK, Raymond KN.2013 Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae. ACS Chem Biol 2013; 8:1882–7.
99 Hider RC, Kong X.2010 Chemistry and biology of siderophores. Nat Prod Rep 2010;27:637–57.
100 Crosa, J.H.;Walsh, C.T.2002 Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria. Microbiol. Mol. Biol. Rev. 2002, 66, 223–249.
101 Fischbach, M.A.; Lin, H.; Zhou, L.; Yu, Y.; Abergel, R.J.; Liu, D.R.; Raymond, K.N.;Wanner, B.L.; Strong, R.K.;Walsh, C.T.; et al.2006The Pathogen-Associated IroA Gene Cluster Mediates Bacterial Evasion of Lipocalin 2. Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507.
102 Garénaux, A.; Caza, M.; Dozois, C.M.2011 The Ins and Outs of Siderophore Mediated Iron Uptake by Extra-Intestinal PathogenicEscherichia coli. Vet. Microbiol. 2011, 153, 89–98.
103 Dauner M, Skerra A 2020. Scavenging Bacterial Siderophores with Engineered Lipocalin Proteins as an Alternative Antimicrobial Strategy. Chembiochem. 2020 Mar 2;21(5):601-606. doi: 10.1002/cbic.201900564. Epub 2019 Dec 13. PMID: 31613035; PMCID: PMC7079049.
104 a) K. Hantke, G. Nicholson, W. Rabsch, G. Winkelmann, Proc. Natl. Acad. Sci. USA 2003, 100,3677–3682;b)B.Bister,D.Bischoff, G. J. Nicholson, M. Valdebenito, K. Schneider,G.Winkelmann,K.Hantke,R.D.Süssmuth, BioMetals 2004, 17,471–481
105 a) M. A. Fischbach, H. Lin, L. Zhou, Y. Yu,R.J.Abergel, D. R. Liu, K. N. Raymond, B. L. Wanner,R.K.Strong, C. T. Walsh, A. Aderem, K. D. Smith, Proc. Natl. Acad. Sci. USA 2006, 103,16502–16507;b)M.A.Fischbach, H. Lin, D. R. Liu, C. T. Walsh, Nat. Chem. Biol. 2006, 2,132–138.ChemBioChem
106 Guo, B., Wang, Q., Li, J., Gan, Z., Zhang, X., Wang, Y., & Du, H. (2017). Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection. 8(39), 65386–65396.
107 Golonka R, Yeoh BS, Vijay-Kumar M. The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity. J Innate Immun. 2019;11(3):249-262. doi: 10.1159/000494627. Epub 2019 Jan 3. PMID: 30605903; PMCID: PMC6487204.
108 Hider RC, Kong X. Chemistry and biology of siderophores. Nat Prod Rep. 2010 May; 27(5): 637–57.
109 Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. (2019). Journal of Structural Biology : X Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology: X, 2(May), 100008. https://doi.org/10.1016/j.yjsbx.2019.100008
110 Holden, V. I., Lenio, S., Kuick, R., Ramakrishnan, S. K., Shah, Y. M., & Bachman, A. (2014). Bacterial Siderophores That Evade or Overwhelm Lipocalin 2 Induce Hypoxia Inducible Factor 1 ␣ and Proinflammatory Cytokine Secretion in Cultured Respiratory Epithelial Cells. 82(9), 3826–3836. https://doi.org/10.1128/IAI.01849-14
111 Wang Y., Zhao S., Han L., Guo X., Chen M., Ni Y., Zhang Y., Cui Z., He P. (2014) Drug resistance and virulence of uro- pathogenic Escherichia coli from Shanghai, China. J. Antibiot. (Tokyo). 67(12): 799–805. https://doi.org/ 10.1038/ja.2014.72; http://dx.doi.org/10.1038/ja.2014.72
112 Munoz-Price, L. S. & Quinn, J. P. The Spread of Klebsiella pneumoniae Carbapenemases: A Tale of Strains, Plasmids, and Transposons. Clinical Infectious Diseases 49, 1739–1741, doi: 10.1086/648078 (2009).
113 Falagas, M. E. & Karageorgopoulos, D. E. Extended-spectrum beta-lactamase-producing organisms. J Hosp Infect 73, 345–354, doi: 10.1016/j.jhin.2009.02.021 (2009).
114 Miro, E. et al. Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates. J Antimicrob Chemother 65, 661–665, doi: 10.1093/jac/dkp504 (2010)
115 Hennequin C., Robin F. (2016) Correlation between antimi- crobial resistance and virulence in Klebsiella pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis. 35(3): 333–341. https://doi.org/10.1007/s10096-015-2559-7; https://www. ncbi.nlm.nih.gov/pubmed/26718943
116 Kallau NHG, Wibawan IWT, Lukman DW, Sudarwanto MB. Detection of multi-drug resistant (MDR) Escherichia coli and tet gene prevalence at a pig farm in Kupang, Indonesia. J Adv Vet Anim Res. 2018;5(4):388–396. doi:10.5455/javar.2018.e289
117 Ibrahim, R. A. (2020). Prevalence of Virulence Genes and Their Association with Antimicrobial Resistance Among Pathogenic E . coli Isolated from Egyptian Patients with Different Clinical Infections. 1221–1236.
118 Cepas, V., & Soto, S. M. (2020). Relationship between Virulence and Resistance among Gram-Negative Bacteria. 1–11.
119 Karam MRA, Habibi M, Bouzari S. Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran. Osong Public Health Res Perspect. 2018 Oct;9(5):217-224. doi: 10.24171/j.phrp.2018.9.5.02. PMID: 30402376; PMCID: PMC6202021.
120 Sundaresan, A. K., Vincent, K., Babu, G., Mohan, M., & Ramakrishnan, J. (2022). Journal of Global Antimicrobial Resistance Association of sequence types , antimicrobial resistance and virulence genes in Indian isolates of Klebsiella pneumoniae : A comparative genomics study. Journal of Global Antimicrobial Resistance, 30, 431–441. https://doi.org/10.1016/j.jgar.2022.05.006
121 Popoiag, R. E., Panaitescu, E., Suceveanu, A. I., Suceveanu, A. P., Micu, S. I., Mazilu, L., Parepa, I., Voinea, F., Costea, D. O., Enache, F., & Fierbințeanu-braticevici, C. (2021). Spontaneous bacterial peritonitis mortality trends of cirrhotic patients in the last decade in Constanta County. 1–6. https://doi.org/10.3892/etm.2021.10164
122 Kim JJ, Tsukamoto MM, Mathur AK, Ghomri YM, Hou LA, Sheibani S, Runyon BA: Delayed paracentesis is associated with increased in-hospital mortality in patients
123 Ding, X., Yu, Y., Chen, M., Wang, C., Kang, Y., & Lou, J. (2019). Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients : community-acquired versus nosocomial infections. 1–8.
124 Cheong HS, Kang CI, Lee JA, Moon SY, Joung MK, Chung DR, Koh KC, Lee NY, Song JH, Peck KR. Clinical significance and outcome of nosocomial acquisition of spontaneous bacterial peritonitis in patients with liver cirrhosis. Clin Infect Dis. 2009;48(9):1230–6.
125 Fernández J, Navasa M, Gómez J, Colmenero J, Vila J, Arroyo V, Rodés J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology. 2002;35(1):140–8.
126 Song JY, Jung SJ, Park CW, Sohn JW, Kim WJ, Kim MJ, Cheong HJ.Prognostic significance of infection acquisition sites in spontaneous bacterial peritonitis: nosocomial versus community acquired. J Korean Med Sci. 2006;21(4):666–71.
127 Chaulk J, Carbonneau M, Qamar H, Keough A, Chang HJ, Ma M, Kumar D, Tandon P. Third-generation cephalosporin-resistant spontaneous bacterial peritonitis: a single-Centre experience and summary of existing studies. Can J Gastroenterol Hepatol. 2014;28(2):83–8.
128 Park YH, Lee HC, Song HG, Jung S, Ryu SH, Shin JW, Chung YH, Lee YS, Suh DJ. Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea. J Gastroenterol Hepatol. 2003;18(8):927–33.
129 Heo J, Seo YS, Yim HJ, Hahn T, Park SH, Ahn SH, Park JY, Park JY, Kim MY, Park SK, et al. Clinical features and prognosis of spontaneous bacterial peritonitis in Korean patients with liver cirrhosis: a multicenter retrospective study. Gut Liver. 2009;3(3):197–204.
130 Macnaughtan J, Jalan R. Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis. Am J Gastroenterol 2015; 110:1399-410; quiz 1411.
131 Bhattacharya, C., Das-mondal, M., & Gupta, D. (2019). Annals of Hepatology Infection in cirrhosis : A prospective study. Annals of Hepatology, 18(6), 862–868. https://doi.org/10.1016/j.aohep.2019.07.010
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Fatma Atef Ibrahim, Alshymaa A. Ahmed, Maha Roushdy Abd El Wahed, Marwan Elgohary, & Rehab Mohamed Ateya. (2023). Value of Neutrophil gelatinase-associated Lipocalin in serum and peritoneal fluids in the Diagnosis of Spontaneous Bacterial Peritonitis and the Prediction of In hospital mortality. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 934–955. https://doi.org/10.53555/jptcp.v30i17.2659
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Author Biographies
Fatma Atef Ibrahim
Department of clinical pathology, faculty of medicine, Zagazig University, Alsharquia, Egypt
Alshymaa A. Ahmed
Department of clinical pathology, faculty of medicine, Zagazig University, Alsharquia, Egypt
Maha Roushdy Abd El Wahed
Department of clinical pathology, faculty of medicine, Zagazig University, Alsharquia, Egypt
Marwan Elgohary
Department of Internal medicine, faculty of medicine, Zagazig University, Alsharquia, Egypt
Rehab Mohamed Ateya
Department of clinical pathology, faculty of medicine, Zagazig University, Alsharquia, Egypt