PREVALENCE OF MULTI DRUG RESISTANT GRAM-NEGATIVE BACTERIA AND ITS SUSCEPTIBILITY PATTERNISOLATED FROM ADMITTED PATIENTSIN A HOSPITAL OF CENTRAL INDIA;AN EMERGING GLOBAL PROBLEM

Main Article Content

Dr.Ashish Saraswat
Deepak Gawali
Abhi Mishra
Dr Nidhi Sharma
Ashok Kumar Rastogi
Mehrunisha Ansari

Keywords

Multi drug resistant, Pulmonary infiltrate, Excessive use of antibiotics

Abstract

Introduction:The multi-drug resistant gram-negative bacterial infections are the principle threats tothe critically ill patients.Multidrug-resistant Gram-negative rods (MDR-GNR) are emerging as amajor challenge to human health.The prevalence of drug-resistant cases is increasing globally.However, the impact of these infections on the patient’s clinical outcome has not yet been clearlyevaluated.


Aim:Todetermine the incidence and associated clinical outcome of multi-drug resistant gram-negative bacterial infections.


Materials and Methods:This record-based retrospective cross-sectional study was designed toanalyseMDR-GNB positive cases at a tertiary care hospital of central India. MLBMedical collegewith attached.Hospital is a700-bedreferral tertiary care centre.An increase of MDR-GNB was seenfrom September 2022 to June 2023 in the hospital. A retrospective analysis of blood culture GNB-positive samples was performed to evaluate MDR-GNB-positive cases at admission.


Results:The total number of positive blood cultures inSeptember2022toJune2023, November toJanuary 2023and February to April2023 were 236,186and206, respectively, with 76.83%,80.%and71.83% GNB-positive. Total MDR-GNB-positive cases were27.08%,34.98% and32.65%,


respectively, and amongst these MDR-GNB, 24%, 32% and5% where positive at time of admissiontothe hospital. The MDR-GNB wereEscherichiacoli,Klebsiella,Acinetobacter,Pseudomonasand
Enterobacter,Klebsiellapneumoniae,Acinetobacterspp.,Pseudomonas aeruginosaandEscherichiacolihave alarming degrees of antimicrobial resistance and are associated with high mortality andmorbidity.


Conclusion:The incidence of multi-drug resistant gram-negative bacterial infections was remarkablyhigh in our hospitals and showed a significant association with healthcare-associated infections andin-hospital-mortality.

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