IMIPRAMINE AMELIORATE ALTERED BIOCHEMICAL PARAMETERS AND OXIDATIVE DAMAGE IN DEPRESSION
Main Article Content
Keywords
Depression, Oxidative stress, lipid peroxidation, reduced glutathione, Serum glutamate oxaloacetate transaminase, Serum glutamate pyruate transaminase, Glucose
Abstract
Background: The study was undertaken to investigate the effect of imipramine on various biochemical parameters and oxidative stress markers in short and long term depression in rats.
Method: Rats were subjected for short (21 days) and long term (84 days) social isolation for and checked for depression on force swim test and tail suspension method. Various markers of oxidative stress like lipid peroxidation (LPO), reduced glutathione (GSH), Supersoxide dismutase (SOD), catalase (CAT) and biochemical parameters like Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruate transaminase (SGPT), and blood glucose were determined in depressed, control, imipramine and Vitamin E treated group.
Result: The rats displayed an increase in depression on force swim test and tail suspension method relative to control. There was a significant increase in the level of LPO and decrease in the levels of GSH, SOD and CAT after short and long term depression.
Conclusion: Increased oxidative stress in depression, which may lead to, alteration of biochemical parameters. Treatment with imipramine (tricyclic antidepressant) significantly decreases the level of LPO, SGOT, SGPT and increase in the levels of GSH, SOD and CAT in long term depression
References
2. Russo A.J., Increased serum Cu/Zn SOD in Individuals with Clinical Depression normalizes after zinc and antioxidant therapy, Nutrition and Metabolic Insights 2010, 3: 1-6.
3. Celeste Bolin And Fernando Cardozo-Pelaez, Assessing Biomarkers of Oxidative Stress:Analysis of Guanosine and Oxidized Guanosine Nucleotide Triphosphates by High Performance Liquid Chromatography with Electrochemical Detection.NIH Public Acess., 2007, 121-130.
4. Yager Sarah, Forlenza M.J., Miller G.E., depression and oxidative damage to lipids, Psychoneuroendocrinology, 2010, 35: 1356-1362.
5. Salam O.M.E. Abdel, Mohammed N.A., Saleem, Farrag A.R., the antidepressant drug on thioacetamide-induced oxidative stress., European review for medical an pharmacological sciences, 2013, 17: 735-744.
6. Sanchez V.V., Chavez T. NC, Uribe M., Mendez S.N., role of oxidative stress and molecular changes in liver fibrosis: a review, Curr. Med. Chem., 2012, 19 (28): 4850-60.
7. Maity T., Adhikari A., Bhattacharya K., Biswas S., Debnath P. K. and Maharana C.S. A study on evalution of antidepressant effect of Imipramine adjunct with Aswagandha and Bramhi. Nepal Med Coll J. 2011, 3(4): 250-253.
8. Kim D.W., Kim D.S., Kim M.J.., Kwon S.W., Ahn E.H., et al., Imipramine enhances neuroprotective effect of PEP-1-Catalase against ischemic neuronal damage, BMB reports, 2011,647-652.
9. Lepola U, Arató M, Zhu Y, Austin C., Sertraline versus imipramine treatment of comorbid panic disorder and major depressive disorder. J Clin Psychiatry. 2003, 64 (6): 654–62.
10. Bebbington P.E. The origin of sex differences in depressive disorder : bridging the gap. International Review of Psychiatry, 1996, 8: 295-332.
11. Sycanlarda Sosyal, Yzolasyonun Oksidan, Stres ve, Eritrosit Deformabilitesi, Uzerine Etkileri. Consequences of Social Isolation in Rats on Their Antioxidant Defense System and Erythrocyte Deformability, Erciyes Typ Dergisi (Erciyes Medical Journal), 2009, 31(1):009-014
12. Gavrilovic L., Spasojevic N., Zivkovic M. and Dronjak S. Effect of immobilization stress on gene expression of catecholamine biosynthetic enzymes in heart auricles of socially isolated rats, Braz J Med Biol Res. 2009, 42(12): 1185-1190.
13. Bajaj, S. and Vohora, S.B. Anti-Cataleptic, Anti-Anxiety And Anti-Depressant Activity Of Gold Preparations Used In Indian Systems Of Medicine Indian J. Pharmacology. 2000, 32(3): 339-346
14. Fedra R. Hinojosa, Luiz Spricigo Jr., Geison S. Izidio, Gustavo R. Bruske, Douglas M. Lopes, Andre Ramos. Evaluation of two genetic animal models in behavioral tests of anxiety and depression, Behavioural Brain Research, 2006 168: 127–136.
15. Stocks J and Dormandy TL. The autoxidation of human red cell lipids induced by hydrogen peroxide. Br. J. Hematol. 1971, 20: 95.
16. Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121.
17. McCord J and Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 1969, 244: 6049-6055.
18. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biphys. 1959, 82: 70-77.
19. Osama M. S., Rawhia E., Harisa G. E. Experimental Diabetic Nephropathy Can Be Prevented By Propolis: Effect on Metabolic Disturbances And Renal Oxidative Parameters Pak. J. Pharm. Sci. 2009, 22( 2) : 205-210.
20. Ambali SF, Shuaib K, Edeh R, Orieji BC, Shittu M, Akande M., Hyperglycemia induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Role of pancreatic lipoperoxidation and alleviating effect of vitamin C, Biology and Medicine, 2011, 3 (1): 6-14.
21. Reitman, S., Frankel, S. A colorimetric method for the determinationof serum glutamic oxaloacetic acid and glutamic pyruvic transaminases. American Journal of Clinical Pathology, 1957, 28: 56–63.
22. Macho L., Ezova D.J., Zorad S., Fickova M. “Postnatal Monosodium Glutamate treatment results in attenuation of corticosterone metabolic rate in adult rats” Endocrine regulations. 1999, 33:61-67.
23. Kitamura Y., Araki H., Nagatani T., Takao K., Shibata and Gomita Y., influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats, Acta Med. Okayama, 2004, 58 (6): 271-274.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
D.S. Mohale
Deepak Suresh Mohale, 91, “Gun-Prabha”, Vaishali Nagar Behind Nandurkar college, Yavatmal, 445001, M.S.Mob. No. 09823654965
O.S. Bilone
P. Wadhwani College of Pharmacy, Yavatmal-445001, Maharashtra, India.
P. J. Wadhwani
P. Wadhwani College of Pharmacy, Yavatmal-445001, Maharashtra, India.
A.V. Shrirao
P. Wadhwani College of Pharmacy, Yavatmal-445001, Maharashtra, India.
S.T. Landge
P. Wadhwani College of Pharmacy, Yavatmal-445001, Maharashtra, India
A.V. Chandewar
P. Wadhwani College of Pharmacy, Yavatmal-445001, Maharashtra, India.