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Dr. Pravin Suradkar
Raj Shekhar
Dr. Amit Gangwal
Dr. Lorika Sahu
Dr. Anima Rout


Anti-inflammatory properties, NSAIDs, ADMET analysis, Albino rats


Inflammation is a complicated biological reaction to damaging stimuli such as infections, poisons, and physical damage. NSAIDs and corticosteroids are commonly used to manage inflammation. NSAIDs function by reducing the COX enzyme activity, which has the role in the formation of prostaglandins, a kind of pro-inflammatory mediator. Most nonsteroidal anti-inflammatory medicines (NSAIDs) are very acidic in nature and are associated with a variety of adverse effects, the most prevalent of which is gastrointestinal damage. Moreover, recently developed NSAIDS are either non-acidic or weakly acidic drug like Nabumetone, Nemuliside and meloxicam possessed substantially lower incidence of gastric ulcers, hence it is worthwhile to explore synthesis of new non-steroidal anti-inflammatory inhibitors with an attempt that these newly developed. Inflammatory inhibitors will exhibit superiority over the already existing acidic anti-inflammatory,non-steroidal, andnon-acidicdrugs. According to researchers, some newer derivatives of quinazolinone, indole, naphthalene, thiadiazole, thiazolidinone, and azetidinone will be synthesized for effective anti-inflammatory agents than existing drugs. We have chosen four compounds quinazolinone, indole, naphthalene, thiadiazole against inflammation and checked the anti-inflammatory properties of these drug compounds on Albino rodents and its ADMET properties.

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