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Dr. Vaghasiya Keyurkumar Mansukhbhai
Dr. Sujata Jadhav
Dr. Ajish Mangot
Dr. Chitra Khanwelkar
Dr. Aditya Shah


Antidepressants, Ashwagandha, Liver function test, MDD (Major depressive Disorder), Sertraline


Aim and Objectives: Aim: To study the effect of administration of sertraline alone and sertraline with ashwagandha on liver function parameters in patients with MDD (Major Depressive Disorder).. Objectives:1.To estimate the effect of sertraline on Liver Function parameters in patients with MDD. 2.To estimate the effect of co-administration of ashwagandha with sertraline on liver function parameters. 3. To compare liver function parameters of both the groups before and after treatment. Material and Methods: This was an open labelled, randomized, comparative, prospective study involving 80 newly diagnosed patients with MDD (Major depressive Disorder) according to inclusion and exclusion criteria. After enrolling, patients were randomly allocated in either of the groups. One who are taking routine treatment with sertraline (Sertraline Group) and another who are given ashwagandha 250mg twice a day with their routine treatment with sertraline (Sertraline + Ashwagandha Group). All liver function parameters were investigated before starting the treatment and reinvestigated after a period of 3 months of drug treatment in both the groups. Results: In sertraline group, values of SGOT, SGPT, Total Protein and Globulin levels were significantly increased. Whereas there was no significant difference in values of other parameters. In sertraline + ashwagandha group, there was no significant difference in values of any liver function parameters before and after three months of treatment. Conclusion: We can conclude prolonged treatment with sertraline can increase few liver function parameters i.e., SGOT, SGPT, Total proteins and Globulin which can be prevented by using ashwagandha with the sertraline. However, sertraline + ashwagandha does not have any effect on any liver parameters.

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