Febrile Seizures in Children: What Do We Know?

Main Article Content

Khaled Saad, Eman F. Gad, Anas Elgenidy, Ibrahim Fawzi , Tariq Agina, ElHussein Eladl , David Maher Zaki , Mohammad A. Elshereef , Abd El-Monem M. Hassan




Febrile seizures (FS), which affect 2-5% of children, are the most common seizure disorder in childhood. Febrile seizures pose a significant challenge in pediatric practice due to their high prevalence in children and their tendency to recur. In the assessment of FS, medical practitioners focus on determining the underlying cause of the fever while simultaneously evaluating the child's overall health and developmental status. It is essential to differentiate febrile seizures from other types of seizures, as the latter may require different management approaches. This article provides an update on the current understanding of febrile seizures, along with an overview of their assessment and treatment.

Abstract 307 | pdf Downloads 202


1. Syndi Seinfeld D, Pellock JM. Recent Research on Febrile Seizures: A Review. J Neurol Neurophysiol. 2013 Sep 25;4(165):19519.
2. Saad K. Childhood epilepsy: an update on diagnosis and management. American Journal of Neuroscience. 2014;5:36–51.
3. Kılıç B. Clinical Features and Evaluation in Terms of Prophylaxis of Patients With Febrile Seizures. Sisli Etfal Hastan Tip Bul. 2019;53(3):276-283.
4. Saad K, Hammad E, Hassan AF, Badry R. Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy. Int J Neurosci. 2014 Mar;124(3):181-6.
5. Fetveit A. Assessment of febrile seizures in children. Eur J Pediatr. 2008;167(1):17–27.
6. Tiwari A, Meshram RJ, Kumar Singh R. Febrile Seizures in Children: A Review. Cureus. 2022 Nov 14;14(11):e31509. doi: 10.7759/cureus.31509.
7. Lux AL. Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizure. Evid Based Med. 2010;15:15–16.
8. Natsume J, Hamano SI, Iyoda K, et al. New guidelines for management of febrile seizures in Japan. Brain Dev. 2017;39(1):2-9.
9. Offringa M, Newton R, Cozijnsen MA, Nevitt SJ. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2017;2:CD003031.
10. Saad K, El-Houfey AA, Abd El-Hamed MA, El-Asheer OM, Al-Atram AA, Tawfeek MS. A randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc in children with intractable epilepsy. Funct Neurol. 2015 Jul-Sep;30(3):181-5.