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Dr. Swathi Gurajala ,Dr. Gayathri Pandurangam ,Dr. Greeshma Matharasi abc


Drug-resistance, drug repurposing, drug repositioning, antimicrobial activity, microbial infections, treatment


Antimicrobial drug repurposing, occasionally referred to as drug repositioning or drug reprofiling, is a strategy used to find novel therapeutic uses for currently available antimicrobial medications. Repurposing currently available medications offers a viable strategy to deal with the rising antimicrobial resistance and the limited supply of innovative antimicrobial medicines that are causing this global health problem. Identifying medications with well-known safety profiles and modes of action that may be useful in treating various microbial targets or diseases . Repurposing avoids many of the early stages of drug development by making use of the substantial information and research already undertaken on existing medications, hastening the discovery of new treatment options. Additionally, by using medications with distinct mechanisms of action, repurposing may be able to overcome drug resistance. Understanding the drug's mechanism of action, conducting high-throughput screening, preclinical investigations, and clinical trials to assess efficacy and safety are often milestones in the process. There are successful cases of repurposing antimicrobial drugs, which shows the promise of this strategy to meet unmet needs in infectious diseases. Antimicrobial medication repurposing, which offers quicker and more affordable options to conventional drug development techniques, is an overall promising strategy to address antimicrobial resistance.

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