Clinicopathological correlation of cutaneous manifestations in chronic kidney disease

Main Article Content



Perforating disorders, chronic kidney disease, Pruritus


Objective: To evaluate the frequency of dermatologic problems among patients with chronic kidney disease at private hospital.
Materials and methods: This is a cross sectional study done after obtaining the patient’s consent. 95 patients attending the dermatology OPD who were diagnosed with chronic kidney disease with cutaneous manifestations are included in the study as per the following inclusion & exclusion criteria.
Results: Out of the 95 cases studied, 60 (63.2%) were males and 35 (36.8%) were females. Maximum CKD patients belonged to the age group between 51-60 years (41.1%). 38 patients (40%) had stage III and 30 patients (31.6%) had stage IV CKD. Out of the 95 CKD patients, 53(55.8%) were under maintenance hemodialysis. Among the cutaneous manifestations, majority of the patients(61%) had xerosis followed by skin infections (32.6%) and perforating dermatosis (16.8%). Skin biopsy done for clinic pathological diagnosis for 41 patients, out of which 29 (70.7%) patients has had positive clinicopathological relationship.
Conclusion: Early recognition of the cutaneous manifestation with the help of specific investigations can prevent or decrease some of the adverse cutaneous changes and reduce morbidity and thereby improving quality of life in these patients.

Abstract 74 | pdf Downloads 66


1. Levillard DT, kambil SM. Cutaneous manifestations in chronic renal disease- An observation study of skin changes, new findings, their association with hemodialysis and their correlation with severity of CKD, IJSRP.2015(5): 1-9
2. Asokan S, Narasimhan M, Rajagopalan V. Cutaneous manifestations in chronic renal failure patients on hemodialysis and medical management. Int J Res Dermatol 2017; 3(1): 24-32
3. Udayakumar P, Balasubramanian S, Ramalingam K S, Lakshmi C, Srinivas C R, Mathew AC. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian J Dermatol Venereol Leprol 2006; 72:119-25
4. Attia EA, Hassan SI, Nagwa M, Youssef. Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case-controlled study. Int J Dermatol 2010; 49: 1024 -1030
5. Beheshti A, Charkhchain M, Zangivand A et al. Dermatological manifestations among patients on maintenance hemodialysis. Wounds 2013; 25: 61-67
6. Deshmukh SP, Sharma YK, Dash K, Chaudhari NC, Deo KS. Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis. Indian Dermatol Online J 2013; 4: 18-21
7. Salem A, Mokadem A, Attwa E, Raoof SA, Ebrahim HM, Faheem KT. Nail changes in chronic renal failure patients under hemodialysis. JEADV 2008; 22: 1326-1331
8. Dyachenko P, Shustak A, Rozenman D. Hemodialysis- related pruritus and associated cutaneous manifestations. Int J Dermatol 2006; 45: 664-667.