Studies On Effect of Super disintegrant and Ph Modifiers in Formulation Of Telmisartan Fast Disintegrating Tablet
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Keywords
Telmisartan, solid dispersion, FDT’s, superdisintegrant, pH modifier
Abstract
Telmisartan is an ARB receptor blocker and is a class II drug having low solubility and high permeability. Fast disintegrating tablet of Telmisartan was formulated by incorporating drug in solid dispersion using carrier PEG 6000. Effect of superdisintegrant i.e., Croscarmellose sodium amd pH modifier i.e., sodium carbonate was investigated in the formulation. 32 factorial design was employed in the formulation. Compatibility of drug with excipients was analysed by DSC and FTIR. Pre-compression evaluation of blend showed good flowability and compressibility. Post-compression evaluation of formulated tablets showed suitable hardness, friability, disintegration and drug release. Optimised formulation F4 reported drug release of 94.01% and disintegration time of 115 seconds. Optimised formulation F4 in comparison with marketed product showed better bioavailability and drug release. Short term stability studies concluded formulation to be stable. Hence fast disintegration tablets of Telmisartan were potential and effective to provide drug with enhanced solubility.
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