Role Of Serum Leptin Levels In Patients With Metabolic Syndrome In A Tertiary Care Hospital In South India

Main Article Content

Sanjeevi Krishnan P
K Shanmuganandan

Keywords

Metabolic syndrome, Insulin resistance, Serum leptin levels, BMI, Blood pressure, HDL, TGL, FBS

Abstract

Background: Metabolic syndrome is a spectrum of metabolic disorders that can lead to cardiovascular issues, and the risk of morbidity and mortality has significantly increased. The study aims to analyze the serum leptin levels in patients with metabolic syndrome and compare them with a disease-free population.
Methods: This cross-sectional study was conducted at the Sree Balaji Medical College and Hospital for 1.5 years. All 81 patients who fulfilled the NCEP ATP -III criteria for metabolic syndrome were selected, and informed consent was obtained from every subject. The physical examination (BMI/waist-hip ratio) or all the old records are collected. All the patients involved in the study were subjected to detailed clinical history, general and systemic examination and routine blood investigations.
Results: The study included 81 patients, 54.3% males and 45.7% females, with a mean age of 44.915.26 years, BMI of 23-24.9, religious distribution of 7.4% Christians, 84% married, education of 14.8% graduates, 43.2% skilled, 49.4% unskilled, 1.25% vegetarian, 98.8% mixed diet. 15% of participants had hypertension, 7.4% had diabetes, 11.1% had SBP >150 mg/dl, 9.9% had fasting blood glucose >126 mg/dl, and all had 150-200 mg/dl of triglyceride levels. Body mass index, blood pressure, waist circumference, triglycerides, HDL, and FBS all positively correlate with serum leptin levels.
Conclusion: Leptin has multiple biological functions that influence autonomic, cardiovascular, and kidney functions and regulate feeding and metabolism. Decreasing leptin through dietary or pharmacological intervention can reduce non-communicable diseases' prevalence.

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