Association between Allergic diseases and irritable bowel syndrome (IBS)

Main Article Content

Kazem Pourabbas
Maryam Baghiani
Abbas Khalili

Keywords

Irritable Bowel Syndrome (IBS), asthma, allergic rhinitis, eczema

Abstract

Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disease and the most common cause of long-term abdominal pain and bowel disorders. The association between allergic disease and IBS is limitedly understood. we aimed to investigate the frequencies of asthma, eczema and allergic rhinitis in IBS patients and as well as the relationship of these allergic diseases with IBS.
Materials and Methods: In this case-control study, we included 300 patients with IBS over 5 years of age who were referred gastrointestinal clinics of Shahid Sadoughi University of Medical Sciences, Yazd in 2021. The control group includes 300 healthy individuals without IBS. Demographic and clinical information of two groups were recorded in the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, based on which eczema, asthma and allergic rhinitis were diagnosed. Then, the frequencies of asthma, allergic rhinitis and eczema was then compared between the two groups.
Results: The frequency of asthma was significantly higher in the IBS group (P<0.001). In addition, allergic rhinitis and eczema frequencies were significantly higher in the group with IBS compared to control group(P<0.001). It was found IBS patients were 5.37 (95%CI: 3.130-8.763) more likely to develop asthma significantly compared to healthy controls. The risk of allergic rhinitis in patients with IBS is 2.87 (95% CI: 1.900-4.084) times higher than non-IBS patients.
Conclusions: Due to the association between IBS and allergic diseases, treatment of comorbid conditions such as asthma, allergic rhinitis, and eczema may be effective in treating IBS. Our data suggest that there is a need to monitor IBS patients for the potential of developing allergic diseases, and vice versa.

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References

1. Wang T, Rijnaarts I, Hermes GD, de Roos NM, Witteman BJ, de Wit NJ, et al. Fecal Microbiota Signatures Are Not Consistently Related to Symptom Severity in Irritable Bowel Syndrome. Digestive Diseases and Sciences. 2022:1-12.
2. El-Salhy M. Irritable bowel syndrome: diagnosis and pathogenesis. World journal of gastroenterology: WJG. 2012;18(37):5151.
3. Camilleri M. Diagnosis and treatment of irritable bowel syndrome: a review. Jama. 2021;325(9):865-77.
4. Siddiqui S, Misra SP, Dwivedi M, Pant S. Irritable Bowel Syndrome and Bronchial Asthma: Are They Associated in Indian Population? Journal of Clinical and Diagnostic Research: JCDR. 2017;11(2):OC21.
5. Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A. Gastrointestinal disorders associated with migraine: a comprehensive review. World journal of gastroenterology. 2016;22(36):8149.
6. Riedl A, Schmidtmann M, Stengel A, Goebel M, Wisser A-S, Klapp BF, et al. Somatic comorbidities of irritable bowel syndrome: a systematic analysis. Journal of psychosomatic research. 2008;64(6):573-82.
7. Hungin A, Whorwell P, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40 000 subjects. Alimentary pharmacology & therapeutics. 2003;17 ( 5 :) 643 - 50 .
8. Tan T-K, Chen A-C, Lin C-L, Shen T-C, Li T-C, Wei C-C. Preschoolers with allergic diseases have an increased risk of irritable bowel syndrome when reaching school age. Journal of Pediatric Gastroenterology and Nutrition. 2017;64(1):26-30.
9. Tobin MC, Moparty B, Farhadi A, DeMeo MT, Bansal PJ, Keshavarzian A. Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Annals of Allergy, Asthma & Immunology. 2008;100(1):49-53.
10. Fang Z-Y, Zhang H-T, Lu C, Lu Q-M, Yu C-H, Wang H-Y. Association between allergic diseases and irritable bowel syndrome: a retrospective study. International Archives of Allergy and Immunology. 2018;177(2):153-9.
11. Eifan AO, Durham SR. Pathogenesis of rhinitis. Clinical & Experimental Allergy. 2016;46(9):1139-51.
12. Jones M, Walker M, Ford A, Talley N. The overlap of atopy and functional gastrointestinal disorders among 23 471 patients in primary care. Alimentary pharmacology & therapeutics. 2014;40(4):382-91.
13. Lacy BE, Mearin F, Chang L, Chey WD, Lembo AJ, Simren M, et al. Bowel disorders. Gastroenterology. 2016;150(6):1393-407. e5.
14. Ng QX, Soh AYS, Loke W, Lim DY, Yeo W-S. The role of inflammation in irritable bowel syndrome (IBS). Journal of inflammation research. 2018;11:345.
15. Ekici A, Guliter S, Ekici M, Kalpaklioglu F, Kara T, Keles H, et al. Irritable bowel syndrome in young and elderly patients with stable asthma. Digestive and liver disease. 2005;37(10):773-8.
16. Shen T-C, Lin C-L, Wei C-C, Chen C-H, Tu C-Y, Hsia T-C, et al. Bidirectional association between asthma and irritable bowel syndrome: two population-based retrospective cohort studies. PLoS One. 2016;11(4):e0153911.
17. Yazar A, Atis S, Konca K, Pata C, Akbay E, Calikoglu M, et al. Respiratory symptoms and pulmonary functional changes in patients with irritable bowel syndrome. The American journal of gastroenterology. 2001;96(5):1511-6.
18. Jun DW, Lee OY, Yoon HJ, Lee HL, Yoon BC, Choi HS, et al. Bronchial hyperresponsiveness in irritable bowel syndrome. Digestive diseases and sciences. 2005;50(9):1688-91.
19. Riccioni G, Della Vecchia R, Menna V, Staniscia T, Di Ilio C, Conti P, et al. Irritable bowel syndrome and bronchial hyperresponsiveness: is there a link? Digestion. 2004;69(3):185 - 9 .
20. Lauriello M, Eibenstein A, Angelone AM, Pasqua M, Tucci C, Di Giacomo C, et al. Association between vasomotor rhinitis and irritable bowel syndrome. Allergy & Rhinology. 2016;7(4):ar. 2016.7. 0184.
21. Nybacka S, Öhman L, Störsrud S, Mybeck M, Böhn L, Wilpart K, et al. Neither self‐reported atopy nor IgE‐mediated allergy are linked to gastrointestinal symptoms in patients with irritable bowel syndrome. Neurogastroenterology & Motility. 2018;30(10):e13379.
22. Rönmark EP, Ekerljung L, Mincheva R, Sjölander S, Hagstad S, Wennergren G, et al. Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clinical and translational allergy. 2016;6(1):1-10.
23. Ziyab AH. Prevalence and risk factors of asthma, rhinitis, and eczema and their multimorbidity among young adults in Kuwait: a cross-sectional study. BioMed Research International. 2017;2017.