Synthesis, Characterization, Biological and Antioxidant estimation of Mixed Schiff Base Ligand and Heterocyclic Compound with Some Metal ions

Main Article Content

Saba H.Mahdi
Dhuha Khudhair Rashid Al-Musawi
Lekaa K.Abdul Karem

Keywords

Schiff base ligand, ortho- phen, elemental analysis, antimicrobial activities, geometry shape

Abstract

In this research, a group of complexes were prepared which were derived from Schiff base ligands, which is called (1E,1'E)-1,1'-(1,2-phenylene)bis(N-(2,4-dichlorophenyl) methanimine) (L) with ortho-phenanthroline (o-phen). The prepared complexes are M(II) [Co(II),Ni(II),Cu(II), Zn(II), Cd(II),and Hg(II)]. A range of spectroscopic and technical techniques have been used to characterize these materials, including: The FTIR, 1H-NMR, LC-Mass Spectrum, UV-Visbale, molar conductance, and magnatic moment, atomic absorbtion, chlorid contents. Spectral results obtained are showen that (ortho-phen) and (L) behave as neutral coordinating to the central metal ion by the donating atoms (N2) of the both compounds. The geometry shape of the mono ligand (L) complexes were tetrahedral, while the geometry shape of mixed ligands (L) as first ligand with (ortho-phen) as second ligand were octahedral geometry. The antimicrobial activities of the prepared compounds were experienced by using disc diffusion process touching different types of selected bacteria; two gram positive and two gram negative, and one type of fungi.

Abstract 102 | PDF Downloads 116

References

1. Ming L , Structure and Function of ‘‘Metalloantibiotics’’. Medical Research and Reviews. 2003; 23: 697-762.
2. Skyes P., "A Guide Book to Mechanisim in Organic Chemistry" Longmans, London. 1974.
3. Kalaivani S, Priya NP, and Arunachalam S, facial synthesis, spectral characterization and biocidal studies. I. J. A. B. P. T. 2012; 3 : 219-223.
4. Keerthi KCT, Keshavayya J, Rajesh T, Peethambar SK. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5 : 1.
5. Wail A. International Journal of Organic Chemistry. 2013; 3 : 73-95.
6. El-Sherif AA, Shehata MR, Shoukry MM, Barakat MHJ. Spectrochemica Acta Part A. 2012; 96: 889-897.
7. El-Sherif AA, Shoukry MM, Abd-Elgawad MMA, Spectrochemica Acta Part A. 2012; 98: 307-321.
8. Konstantinivi SS, Radovanovi BC, Caki ., Vasic V. J. Ser. Chem. Soc. 2003; 68: 641-648.
9. Luman CR, Castellano FN, Phe.
10. Sammes PG, Yahioglu G, Chemical Society Reviews. 1994; 23: 327-334.
11. Farrell N, Transition Metal Complexes as Drugs and Chemotherapeutic Agents,Kluwer Academic, Dordrecht. 1989.
12. Saba HM, Lekaa KAK, International Journal of Pharmaceutical research. 2020; 1:1734-1740.
13. Hanan FAE, Gehad GM, Eman AMK, Journal of Moulecular Stracture. 2017; 5: 92.
14. Agwara MO, Ndifon PT, Ndosiri AB, Paboudam AG, Yufanyi DM, and Mohamadou A. Chemical Society of Ethiopia. 2010; 24(3): 383-389.
15. Reddy PM, Prasad AVS, Rohini R and Ravinder V,.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2008; 70: 704-712.
16. Rehab KR, Lekaa KAK and Faaza HG. Oriental Journal of chemistry. 2018; 34 (2): 1105-1113.
17. Taghreed HAN. and Lekaa KAK. Journal of Medical Sciences. 2016; 3(2): 64-75.21.
18. Fernandez TM J, International journal of chemistry. 2013; 9(2): 33-40. 19. Yuan F. Li, Xiao W. Shen, Cheng Z. Huang; (2008) : 1041-1045.
20. Saba HM, Lekaa KA, Oriental Journal of Chemistry. 2018; 34 (3): 1566.
21. Silverstein RM, Bassler GC, and Morrill TC. Spectroscopic Identification of Organic Compounds. 4th Ed, John Wiley and Sons, NJ. USA. 1981; 112-132.
22. Merve E, Ali C, and Levent T.Synthesis and characterization of conductingcopolymers of succinic acid bis-(4-pyrrol-1-yl-phenyl) ester and their electrochromic properties. Journal of the Synthetic Metals . 2004; 143.pp 49–58.
23. Kamaljit S, Hardeep K, and Prasad VB. European Journal of Medicinal Chemistry. 2012; 52.pp 82-97.
24. Sharma RSB, Reddi SB and Hattacharya RN.. Journal of Solid State Chemistry. 2012; 190.pp 226–232.
25. Al-Obidi LK, and Al-Noor TH. Ibn AL-Haitham Journal for Pure and Applied Science. 2018; 235-247.
26. Naji Sh H, Lekaa KA, and Falih HM. Ibn AL-Haitham Journal for Pure and Applied Science. 2017; 26.1 193-207.
27. Meixian HU, Ning LI, Kemin Yao, Frontier chemistry in chaina. 2006; 4: 369-373.
28. Sharma R, Samadhiya P, Srivastava SD, Srivastava SK, journal of organic community. 2011; 4: 369-373.
29. Manjula VD, Chakraborty and Bhattacharya PK, Indian Journal of Chemistry Section A: Inorganic Bioinorganic Physical Theoretical and analytical Chemistry. 1990; 29(6): 577-580.
30. Al-Hamdani A A S, Balkhi AM, Falah A and Shaker ShA, Journal of the Chilean Chemical Society. 2015; 60 (1): 2774-2785.
31. Al-Noor TH, Mohapatra RK, Azam M, Karem, L KA, Mohapatra PK, Ibrahim AA, Pintilie L. Journal of Molecular Structure, 2021; 1229, 129832.