COMPARING FOLIC ACID PHARM ACOKINETICS AMONG WOMEN OF CHILDBEARING AGE: SINGLE DOSE INGESTION OF 1.1 MG VERSUS 5 MG FOLIC ACID

Main Article Content

Patricia Nguyen
Rada Boskovic
Parvaneh Yazdani
Bhushan Kapur
Hilde Vandenberghe
Gideon Koren

Keywords

Folic acid, pharmacokinetics, NTD, pregnancy, multivitamin

Abstract

Background


A 2001 study suggested that supplementation with 5 mg folic acid, among women of childbearing age, is needed to render maximum protection against neural tube defects (NTD). No human study is presently available which examined the pharmacokinetics of 5 mg folic acid.


 Objective


To compare the pharmacokinetics of ingesting a single dose of 5 mg versus 1.1 mg folic acid contained in 2 prenatal multivitamins (PregVit®  and PregVit-Folic 5®), and to estimate its contribution to steady-state folate levels.


 Method


The pharmacokinetics of 1.1 mg folic acid was determined in a previously published study. The method was replicated among 6 healthy, non-pregnant women who were given 5 mg folic acid to ingest. Blood samples were drawn and serum folate concentrations  were measured at various time points during 10 hours  post-ingestion.   Standard   pharmacokinetic   parameters   were   determined   and  compared   with Student’s t-test, when appropriate.


 Results


The mean area under the curve (AUC) of 1.1 mg and 5 mg folic acid were 147.6 ± 52.8 (ng/mL)?hr and 997.5 ± 271.9 (ng/mL)?hr, respectively (p<0.0002). An approximate 5-fold difference was detected in the peak concentrations (Cmax ) between the 2 groups (p<0.0005), alongside a slight difference in the times to peak (Tmax) (p=0.02). The estimated steady-state serum folate concentrations produced by 1.1 mg and 5 mg  folic  acid  were  6.2  ±  2.2  ng/mL  and  41.6  ±  11.3  ng/mL,  respectively  (p<0.0002),  prior  to  its summation with initial (baseline) steady-state levels.


 Conclusion


Single dose administration between 1.1 mg and 5 mg folic acid demonstrated linear pharmacokinetics, with approximately a 5-fold difference between the 2 doses in serum folate contribution to steady-state levels, under ideal adherence.

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