Anatomical Evaluation of The Corpus Callosum in Multiple Sclerosis Patients Using MRI

Main Article Content

Hussam Alabdullah
Mennan Ece Pirzirenli
Aslı Tanrıvermiş Sayıt
Aymen Warille

Keywords

corpus callosum, multiple sclerosis, MRI, brain atrophy

Abstract

Background: Multiple sclerosis MS is a chronic, complicated disease of still unknown exact etiology that impacts the whole central nervous system (CNS). Corpus callosum atrophy in MS patients may serve as a disease-progression biomarker because it is a representation of the permanent process of degenerative injury. We designed this study with the aim of addressing the anatomical changes of the corpus callosum in multiple sclerosis patients using easy linear MRI measurements and comparing the results with those in the normal population.
Methods: MRI images for 50 participants (25 MS patients and 25 healthy controls) were collected. The chosen MRI scans were carried out between 2017 and 2021. Five anatomical parameters of the corpus callosum were measured in the best MRI mid-sagittal plane.
Results: In the patient group, the mean thickness of genu G, body B, splenium S, anterior-posterior diameter AP, and corpus callosum index CCI were 9.75 ±1.85mm, 4.83±1.17 mm, 9.96±2.1 mm, 66.24 ±4.33 mm, and 0.37 ±0.06 respectively. In the control group, the mean G, B, S, AP, and CCI were 12.9 ±1.86mm, 7.54 ±1.19mm, 13.01±1.53mm, 69.72±4.47mm, and 0.48±0.04 respectively. The results of the t-test revealed that there is a statistically significant difference between the two groups for G (P=0.000), B (P=0.000), S (P=0.000), AP (P=0.008), and CCI (P=0.000). All dimensions were smaller in the patients group than in the control group.
Conclusion: Morphometric evaluation revealed that patients with MS had significantly thinner CC segments than their neurologically normal counterparts. We believe that these findings may serve as a baseline to guide subsequent analyses with other groups, as well as studies of forensic and MS-related alterations in the CC in Turkish young adults.

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