Evaluation some immune aspects in Iraqi women patients with breast cancer
Main Article Content
Keywords
breast cancer, Naturall killer cells, dendritic cells,CD56,CD1a.
Abstract
The current experiment have been conducted to to determinate the activity of natural killer cells of CD56 and dendritic cells of CD1a by estimating the expression for both markers depending on flow cytometery technique . Blood samples are taken from 60 patients women with breast cancer to represent patients group and 40 women’s without breast cancer to represent control group, the ages of both groups ranged from 30 to more than 50 years in the Al.Diwaniyah General Teaching Hospital in AL-Qadisyaha province .
Also ROC curve analyzed is used to demonstrate the accuracy and validity of previous parameters in detecting women with breast cancer and to estimate the sensitivity and specificity.
The results of this study show that the patients group have recorded highly significant (p<0.01) superiority in natural killer cells of CD56 (23.780) comparison with control group which is (10.708 ) , in addition to the patients group have appeared significant increase in dendritic cells of CD1a on control group by 5.741. .
Age groups have showed significant (p<0.05)effect on natural killer cells of CD56 , there is decline in natural killer cells of CD56 with age progress, while the decline in dendritic cells of CD1a with age progress do not reach to significant level .
Analysis of ROC curve for CD56 and CD1a has been showed that these characters are excellent indicators to detecting actually patients with breast cancer,the sensevity and specificity for CD56 and CD1a is 90.90,20 and 25% respectively. The cut-off for CD56 and CD1a is more 11.85 and more than 2.65 respectively.
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