New sulfamethoxazole derivatives contain 1,2,3-triazoline ring in Vitro antibacterial agents

Hayder Ghanim Chfat; Ezzat Hussein Zimam

doi:10.47750/jptcp.2023.30.13.017

Hayder Ghanim Chfat

Ministry of Education, The General Directorate of Educational in Najaf Al-Ashraf, Najaf, Iraq

Ezzat Hussein Zimam

Department of Chemistry, Faculty of Science, Kufa University, Al-Najaf-Iraq

Keywords

1,2,3-triazoline, Sulfametoxazole, Antibacterial activity, Click chemistry, Alkyl chain

Abstract

Triazoles stand out among the heterocyclic nitrogen-containing chemicals for their exceptional pharmacological uses. In this study, 6 novel sulfamethoxazole-triazole derivatives were synthesized and their antibacterial activities were investigated. Using melting point and spectroscopic methods (1H and 13C NMR), the produced compounds were thoroughly analyzed. Compounds (9 and 12) showed the greatest efficacy against E. coli with an inhibitory zone of 18 μg/mL when the in vitro antibacterial activities of synthesized compounds were assessed against two bacterial strains, S. aureus and E. coli. In addition, compound (12) with a MIC value of 22 μg/mL.had the strongest antibacterial activity against Staphyloccocus aureus.

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Published

Jun 3, 2023

DOI https://doi.org/10.47750/jptcp.2023.30.13.017

How to Cite

Hayder Ghanim Chfat, & Ezzat Hussein Zimam. (2023). New sulfamethoxazole derivatives contain 1,2,3-triazoline ring in Vitro antibacterial agents. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 170–177. https://doi.org/10.47750/jptcp.2023.30.13.017