Synthesis new derivatives related to indole contains 1,3,4-thiadiazole ring tethered to β-lactam ring and study their antibacterial activity

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Rana Ali Hussein
Ziad T I Alkayar


Indole-3-acetic acid, 1,3,4-thiadiazole, β-lactam, antibacterial


Indole are important heterocyclic in medicinal compounds. We report the synthesis of some compounds related to indole, the reaction of indole-3-acetic acid (IAA) with thiosemicarbazide in the presence of POCl3 gave good yield of compound 5-((1H-indol-3-yl)methyl)-1,3,4-thiadiazol-2-amine (1). Then imine group was generated by the reaction of compound (1) with different aldehydes to give compound 2a-f in good yields. Further treating with chloroacetyl chloride produced compounds 3a-f with β-lactam in good yields. The antibacterial activities were tested against two types of bacteria; gram +ve and –ve and the results were good.

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