Synthesis and biological activity of 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones and their o -glucosides

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Mahavir Chhajed
Vidyasagar College of Pharmacy, Indore, (M.P.) – India

Sumeet Dwivedi
Acropolis Institute of Pharmaceutical Education and Research, Indore, (M.P.) – India

Shikha Jain
Royal Institute of Pharmacy, Ratlam, (M.P.) – India

Rahul Shriramsa Bijwar
Jagadambha Institute of Pharmacy & Research, Kalamb, Yavatmal, (M.H.) – India

Sachin Vijay Chordiya
Gangamai Institute of Pharmacy, Nagaon, Dhule, (M.H.) – India

Bharti Khichi
Senior Research, SAGE University, Bhopal, (M.P.) – India

Shrutika Joshi
Faculty of Pharmacy, Oriental University, Indore, (M.P.) – India

Atika Chhajed
Vidyasagar College of Pharmacy, Indore, (M.P.) – India

Keywords

Oxazolone, α - acetobromoglucose, decetylation, o -glucosides, antimicrobial and antifungal activity.

Abstract

The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 treated with various aldehydes in the presence of acetic acid to form 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i which were glucosylated by using α-acetobromoglucose as a glucosyl donor to affords 4-(4-o-β-d-tetra-o-acetyl- glucoxybenzylidene)-2-(substituted styryl) oxazol-5-ones 3a-i which was deacetylated by using Zinc acetate in absolute methanol to formed 4-(4-o-β-d-glucoxybenzylidene)-2-(substituted styryl) oxazol-5-ones 4a-i. Compounds showed good antimicrobial and antifungal activity.

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Published
Jun 1, 2023
DOI https://doi.org/10.47750/jptcp.2023.30.12.025

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How to Cite
Mahavir Chhajed, Sumeet Dwivedi, Shikha Jain, Rahul Shriramsa Bijwar, Sachin Vijay Chordiya, Bharti Khichi, Shrutika Joshi, & Atika Chhajed. (2023). Synthesis and biological activity of 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones and their o -glucosides. Journal of Population Therapeutics and Clinical Pharmacology, 30(12), 218–226. https://doi.org/10.47750/jptcp.2023.30.12.025
Issue
Vol. 30 No. 12 (2023): JPTCP
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