Administration of Ulva lactuca increased the expression of AR and ER mRNA receptors in ovaries after Monosodium Glutamate induction in Ratts
Main Article Content
Keywords
Ulva lactuca, mRNA AR and ER, Monosodium glutamate, Ovarian disorders, Hormonal regulation
Abstract
Excessive consumption of foods containing monosodium glutamate (MSG) can trigger ovarian disorders, especially in hormonal regulation, leading to adverse effects on DNA activation for mRNA transcription and protein synthesis. Ulva lactuca, a type of seaweed, is a natural therapy for treating this condition due to its various nutrients, antioxidants, and sterols. The aim of this study was to investigate whether the administration of Ulva lactuca could increase ovarian AR and ER mRNA receptors after exposure to MSG, a toxic agent. A true experiment was conducted using 30 females Rattus norvegicus divided into five groups. Statistical analysis using the Kruskal Wallis test revealed that AR mRNA showed a P value of 0.007, ERα showed a P value of 0.084, and ERβ showed a P value of 0.018. This suggests that there was a significant difference in AR and ERβ mRNA expression between the control group and the Ulva lactuca treatment group, which tended to increase after initial exposure to MSG. These findings indicate that the administration of Ulva lactuca can improve ovarian function after exposure to MSG-induced organ dysfunction.
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Luh Ari Arini, Eddy Bagus Wasito, & Arifa Mustika. (2023). Administration of Ulva lactuca increased the expression of AR and ER mRNA receptors in ovaries after Monosodium Glutamate induction in Ratts. Journal of Population Therapeutics and Clinical Pharmacology, 30(11), 239–264. https://doi.org/10.47750/jptcp.2023.30.11.026
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