Role Of Oxidative Stress as An Etiological Agent in Temporomandibular Disorders: A Systematic Review
Main Article Content
Keywords
TMD, Temporomandibular disorders, TMJ, oxidative stress, splints
Abstract
Introduction: Since oxidative stress is related to the pathogenesis of TMD, it has been shown that an increase in the generation of free radicals, the release of neuropeptides and cytokines, and the activation of matrix-degrading enzymes from various TMJ tissues were observed. Few studies reported reactive oxygen species (ROS) in TMD. This systematic review aimed to evaluate the role of oxidative stress as an etiological agent in temporomandibular disorders.
Materials And Methods: The search was done on Pubmed, Embase, and Cochrane till January 2023. A title scan was done to identify relevant articles, which were further analyzed for inclusion criteria. Studies that assessed the oxidative stress markers before and after any treatment modality in TMD patients, were included.
Results: A total of three studies were included in this review, which consisted of prospective clinical trials. Risk of bias assessment was done by RevMan software. All the studies show low risk of bias. The included studies show occlusal splints is proven to be effective in the managment of TMD with reduction of oxidative stress marker levels.
Conclusion: It is evident that improvement of the oxidative stress would raise the possibility of constructing novel treatment strategies for TMD. We could postulate new treatment strategies such as antioxidant therapy for TMD in the near future.
References
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29. J, Pradeep Christopher, Thenaruvi Marimuthu, Krithika C, Poorna Devadoss, and Santhosh M. Kumar. 2018. “Prevalence and Measurement of Anterior Loop of the Mandibular Canal Using CBCT: A Cross Sectional Study.” Clinical Implant Dentistry and Related Research 20 (4): 531–34.
30. Kanimozhi, I., Mahesh Ramakrishnan, Dhanalakshmi Ravikumar, and Ningthoujam Sharna. 2018. “Management of Crown-Root Fracture in Primary Canine by Surgical Extrusion: A Case Report with 1-Year Follow-Up.” Case Reports in Dentistry 2018 (August): 3753807.
31. Kavarthapu, Avinash, and Kaarthikeyan Gurumoorthy. 2021. “Linking Chronic Periodontitis and Oral Cancer: A Review.” Oral Oncology 121 (October): 105375.
32. Marimuthu, Madhulaxmi, Manoharan Andiappan, Abdul Wahab, M. R. Muthusekhar, Anandan Balakrishnan, and Sambandham Shanmugam. 2018. “Canonical Wnt Pathway Gene Expression and Their Clinical Correlation in Oral Squamous Cell Carcinoma.” Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research 29 (3): 291–97.
33. Ramesh, Asha, Radha Vellayappan, Sheethalan Ravi, and Kaarthikeyan Gurumoorthy. 2019. “Esthetic Lip Repositioning: A Cosmetic Approach for Correction of Gummy Smile - A Case Series.” Journal of Indian Society of Periodontology 23 (3): 290–94.
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2. Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015 Mar 15;91(6):378–86.
3. Thaddeus Connelly S, Tartaglia GM, Silva RG. Contemporary Management of Temporomandibular Disorders: Fundamentals and Pathway to Diagnosis. Springer; 2019. 227 p.
4. Temporomandibular disorders. Am Fam Physician. 2015 Mar 15;91(6):Online.
5. American Academy of Family Physicians. Temporomandibular joint (TMJ) pain. Am Fam Physician. 2007 Nov 15;76(10):1483–4.
6. Mishra R. Global Burden of Temporomandibular Disorder (TMD): A Systematic Review of TMD Prevalence and Incidence (1990- January 2019). 2019. 55 p.
7. Rauch A, Angrik C, Zenthöfer A, Weber S, Hahnel S, Nitschke I, et al. [Prevalence of temporomandibular disorders in seniors-Symptom-related analyses in younger and older seniors]. Z Gerontol Geriatr [Internet]. 2021 Aug 5; Available from: http://dx.doi.org/10.1007/s00391-021-01954-z
8. Nagori SA, Roy Chowdhury SK, Thukral H, Jose A, Roychoudhury A. Single puncture versus standard double needle arthrocentesis for the management of temporomandibular joint disorders: A systematic review. J Oral Rehabil. 2018 Oct;45(10):810–8.
9. Hilgenberg-Sydney PB, Schenato LF, Marques HB, de Paiva Bertoli FM, Bonotto D. Interexaminer reliability for tomographic findings in temporomandibular joint degenerative disease and its agreement with clinical diagnosis: a blinded controlled cross sectional study. Oral Radiol. 2022 Jan;38(1):155–61.
10. Milam SB, Zardeneta G, Schmitz JP. Oxidative stress and degenerative temporomandibular joint disease: a proposed hypothesis. J Oral Maxillofac Surg. 1998 Feb;56(2):214–23.
11. Özben T. Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance. Springer Science & Business Media; 2013. 395 p.
12. Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757–72.
13. Website [Internet]. Available from: Hilgenberg-Sydney PB, Schenato LF, Marques HB, de Paiva Bertoli FM, Bonotto D. Interexaminer reliability for tomographic findings in temporomandibular joint degenerative disease and its agreement with clinical diagnosis: a blinded controlled cross sectional study. Oral Radiol [Internet]. 2021 May 24; Available from: http://dx.doi.org/10.1007/s11282-021-00539-1
14. Muthukrishnan A, Sekar G. Prevalence of temporomandibular disorders in Chennai population [Internet]. Vol. 27, Journal of Indian Academy of Oral Medicine and Radiology. 2015. p. 508. Available from: http://dx.doi.org/10.4103/0972-1363.188686
15. Cai HX, Luo JM, Long X, Li XD, Cheng Y. Free-radical oxidation and superoxide dismutase activity in synovial fluid of patients with temporomandibular disorders. J Orofac Pain. 2006 Winter;20(1):53–8.
16. Güven O, Tekin US, Durak I, Keller EE, Hatipoglu M. Superoxide dismutase activity in synovial fluids in patients with temporomandibular joint internal derangement. J Oral Maxillofac Surg. 2007 Oct;65(10):1940–3.
17. Nitzan DW, Goldfarb A, Gati I, Kohen R. Changes in the reducing power of synovial fluid from temporomandibular joints with “anchored disc phenomenon.” J Oral Maxillofac Surg. 2002 Jul;60(7):735–40.
18. Richards RS, McGregor NR, Roberts TK. Association Between Oxidative Damage Markers and Self-Reported Temporomandibular Dysfunction Symptoms in Patients with Chronic Fatigue Syndrome [Internet]. Vol. 12, Journal of Chronic Fatigue Syndrome. 2004. p. 45–61. Available from: http://dx.doi.org/10.1300/j092v12n03_04
19. Rodríguez de Sotillo D, Velly AM, Hadley M, Fricton JR. Evidence of oxidative stress in temporomandibular disorders: a pilot study. J Oral Rehabil. 2011 Oct;38(10):722–8.
20. Almeida C de, de Almeida C, Amenábar JM. Changes in the salivary oxidative status in individuals with temporomandibular disorders and pain [Internet]. Vol. 6, Journal of Oral Biology and Craniofacial Research. 2016. p. S1–4. Available from: http://dx.doi.org/10.1016/j.jobcr.2016.10.006
21. Vrbanović E, Lapić I, Rogić D, Alajbeg IZ. Changes in salivary oxidative status, salivary cortisol, and clinical symptoms in female patients with temporomandibular disorders during occlusal splint therapy: a 3-month follow up. BMC Oral Health. 2019 Jun 6;19(1):100.
22. Etöz OA, Akçay H, Neşelioğlu S, Erel Ö, Alkan A. Total antioxidant capacity and total oxidant status of synovial fluids in patients with temporomandibular joint pain and dysfunction. Clin Oral Investig. 2012 Dec;16(6):1557–61.
23. Vrbanović E, Alajbeg IZ, Vuletić L, Lapić I, Rogić D, Rogulj AA, et al. Salivary Oxidant/Antioxidant Status in Chronic Temporomandibular Disorders Is Dependent on Source and Intensity of Pain – A Pilot Study [Internet]. Vol. 9, Frontiers in Physiology. 2018. Available from: http://dx.doi.org/10.3389/fphys.2018.01405
24. Atul Tanaji Lakde & Dr. Laxman Babasaheb Patil. 2023. Indian Council of Social Science and Research Celebrating Azadi Ka Amrit Mahotsav Sponsored. Ashok Yakkaldevi.
25. Chandrasekar, Raghavan, Shyamala Chandrasekhar, K. K. Shantha Sundari, and Poornima Ravi. 2020. “Development and Validation of a Formula for Objective Assessment of Cervical Vertebral Bone Age.” Progress in Orthodontics 21 (1): 38.
26. Govindaraju, Lavanya, and Ganesh Jeevanandan. 2023. “Evaluation of the Antimicrobial Efficacy of Different Concentrations of a Novel Root Canal Filling Material for Primary Teeth - An Study.” Dental Research Journal 20 (February): 20.
27. Gupta, Pushkar, Padma Ariga, and Suryakant C. Deogade. 2018. “Effect of Monopoly-Coating Agent on the Surface Roughness of a Tissue Conditioner Subjected to Cleansing and Disinfection: A Contact Profilometric Study.” Contemporary Clinical Dentistry 9 (Suppl 1): S122–26.
28. Jeevanandan, Ganesh, Lavanya Govindaraju, Erulappan Muthu Ganapathi Subramanian, and Pragyna Priyadarshini. 2021. “Comparative Evaluation of Quality of Obturation and Its Effect on Postoperative Pain between Pediatric Hand and Rotary Files: A Double-Blinded Randomized Controlled Trial.” International Journal of Clinical Pediatric Dentistry 14 (1): 88–96.
29. J, Pradeep Christopher, Thenaruvi Marimuthu, Krithika C, Poorna Devadoss, and Santhosh M. Kumar. 2018. “Prevalence and Measurement of Anterior Loop of the Mandibular Canal Using CBCT: A Cross Sectional Study.” Clinical Implant Dentistry and Related Research 20 (4): 531–34.
30. Kanimozhi, I., Mahesh Ramakrishnan, Dhanalakshmi Ravikumar, and Ningthoujam Sharna. 2018. “Management of Crown-Root Fracture in Primary Canine by Surgical Extrusion: A Case Report with 1-Year Follow-Up.” Case Reports in Dentistry 2018 (August): 3753807.
31. Kavarthapu, Avinash, and Kaarthikeyan Gurumoorthy. 2021. “Linking Chronic Periodontitis and Oral Cancer: A Review.” Oral Oncology 121 (October): 105375.
32. Marimuthu, Madhulaxmi, Manoharan Andiappan, Abdul Wahab, M. R. Muthusekhar, Anandan Balakrishnan, and Sambandham Shanmugam. 2018. “Canonical Wnt Pathway Gene Expression and Their Clinical Correlation in Oral Squamous Cell Carcinoma.” Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research 29 (3): 291–97.
33. Ramesh, Asha, Radha Vellayappan, Sheethalan Ravi, and Kaarthikeyan Gurumoorthy. 2019. “Esthetic Lip Repositioning: A Cosmetic Approach for Correction of Gummy Smile - A Case Series.” Journal of Indian Society of Periodontology 23 (3): 290–94.
34. Vijayashree Priyadharsini, J., A. S. Smiline Girija, and A. Paramasivam. 2018. “An Insight into the Emergence of as an Oro-Dental Pathogen and Its Drug Resistance Gene Profile - An in Silico Approach.” Heliyon 4 (12): e01051.
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May 13, 2023
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Pavithra M, & Arvind Muthukrishnan. (2023). Role Of Oxidative Stress as An Etiological Agent in Temporomandibular Disorders: A Systematic Review. Journal of Population Therapeutics and Clinical Pharmacology, 30(10), 154–161. https://doi.org/10.47750/jptcp.2023.30.10.020
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