The prevelance of inapproperiate use of proton pump inhibitors and its associated side effects among Basrah city population

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Sheima N. Kadhim
Asmaa M. Al-Ali
Muntadher L. Abdulsahib


Proton pump inhibitors, Inapproperiate use, self-treating, adverse effects


One of the most often prescribed medications is PPIs (proton pump inhibitors). Because of an increase in proton pump inhibitors that may be purchased without a prescription, their use is probably even higher than previously thought. Regrettably, Proton pump inhibitors are frequently used off-label for prolonged durations of time. In the last two decades, there has been an upsurge in the use of PPIs, raising concerns about their potential side effects. Numerous research have looked into the connection between infection and PPI use, notably pneumonia and Clostridium difficile. It is hypothesized that PPI use alters the gastrointestinal microbiota, which creates an environment that is favorable for the growth of these infections. It has been reported by at least one study that dementia risk may be increased by long-term PPI use. When prescribing any medication, drug interactions are a crucial but frequently ignored factor. One of the latest concerns about the use of PPI is its role in progression or development of chronic renal disease.
Thus, This study's aim was to evaluate the prevelance of improper use of proton pump inhibitors and to estimate the link between the use of PPI and its associated severe side effects given growing worries regarding PPI misuse in the general population.
Methodology and Study design: This study is a questionnaire-based descriptive study, carried out from November 2021 to April 2022, the data collected from 406 individuals (83 males and 323 females), average of age (6-58) who were taken any type of PPI or not taken any one in Basrah city, the second questionnaire was specific for pharmacist in Basra (71) which composed (12) questions. The ethics committee of college of pharmacy university of Basrah approved the protocol.
Result: The questionnaire was collect and responses of 406 participant were analyzed 196(48.3%) of them wrere used PPI, most of them 153(78.1%)were females.Also the large number of PPI user 171(87.2%)were unhealthy with different comorbid illnesses. omeprazole was the most popular choice among the study's participants, took by 110 (56.1%). 77 (39.3%), 21(29.6%) were taken their treatment by Physician prescription as shown on individual and pharmacist questionnaire respectively, and 54 (27.6%), 21(29.6%) treated by pharmacist prescription. In addition the results showed large number of participants were on self-treating without prescription 44 (22.4%), 29(40.8%) as shown on individual and pharmacist questionnaire respectively. Headaches affected about 30 (15.3%) of PPI user participants, and nausea affected about 40 (20.4%). In addition to 27 (13.8%) cases of abdominal pain, 30 (15.3%) cases of constipation, 20 (10.2%) cases of diarrhea, 5 (2.6%) cases of skin rash, and13 (6.6%) cases of muscle spasm and arrhythmia. In addition, some participants have kidney illness 10 (5.1%) or hematuria (2, 1%)and (2, 1%) bone fruture however 111 (56.6%), of them do not have any symptoms.
Conclusion: It's necessary to carefully balance the benefits and risks of long-term PPI use, notably in young patients, whose treated with these drugs may continue for many years. Although these medications have a number of known system-related side effects, for most patients with appropriate short-term causes, PPIs' benefits are expected to outweigh their dangers.

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