Estimation of Spexin level and some biochemical indicators in obese and non-obese woman's with polycystic ovary syndrome

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Zainab Eskander Mahmood
Sayran Sattar Saleh


Periodontitis, Estimation, Control


The research aimed to measure the level of the hormone spexin and a number of biochemical variables, including (glucose, cholesterol (ch), triglycerides (T.G), very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), high-density lipoproteins ( HDL) in obese, non-obese, non (PCOS) women.
The research was conducted on (90) blood samples, 60 samples from patients with (PCOS) and 30 of them were healthy females. Blood samples were collected from women attending outpatient clinics in Kirkuk Governorate, after their diagnosis. By obstetrics and gynecology doctors for the period from 11/20/2021 to 25/2/2022, as their ages ranged between (17-42) years, and they according to the body mass index, into three groups was divided, The first group (30) samples for patients with (PCOS) who are obese with BMI of more than 30 kg / m2, and the second group (30) samples for ladies without obesity who have polycystic ovarian syndrome with BMI less than 25 kg / m2, and the third group (30) samples for non-infected women Those with BMI more than 30 kg/m2 as the control group.
The findings of this research show following:
*A notable reduction (P≤0.05) in the level of the hormone spexin when comparing the obese group of PCOS women with the healthy female, However a significant decrease shown P- value (P≤0.01) when comparing the obese women with PCOS with the non-obese.
* There are non-significant differences in the value of body mass index when comparing between female suffers (PCOS) and healthy individuals, while the results reported rose in ( BMI) when comparing two groups, the probability level (P0.01) women with PCOS who are obese and non-obese.
* P- Value rise (P 0.01) in glucose concentration when comparing obese PCOS patients with control, while the reported showed raised (P≤0.05) when comparing obese PCOS patients with non-obese PCOS patients.
P- Value rise (P≤0.01)) in the booth's concentration triglycerides and very low-density proteins when comparing obese PCOS patients with control, and also when comparing between PCOS individuals with and without obesity.
* Increase that is statistically significant (P 0.05) in the concentration both cholesterol and low-density lipoproteins when comparing obese women with PCOS with control, and no significant differences when comparing between PCOS-afflicted obese and non-obese women.
* A non-significant decrease when concentrating of LDL in obese PCOS patients to compared with healthy individuals. It reported lowered when comparing obese PCOS female with non-obese ones.Estimation of Spexin level and some biochemical indicators in obese and non-obese woman's with polycystic ovarysyndrome

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