Correlations of cancer antigen 19-9 and Carcinoembryonic antigen with histopathological and clinical features among malignant thyroid tumors

Main Article Content

Yadgar Aziz Abdullah
Abdulwahid Mohammed Salih
Ari Mohammed Abdullah
Mohammed Abdalkarim Hama Ali
Ali Hattem Hussain

Keywords

Thyroid, tumors, CEA, CA 19-9, Sulaimani city

Abstract

Background: CEA and CA19-9 are important serum tumor marker for malignant tumors especially gastrointestinal tumors. This study aimed to reveal the correlations of CA19-9 and CEA titers with malignant thyroid tumors (MTTs).
Methodology: This study enrolled patients’ with MTTs (n=50), and control group (n=50). Thyroid biopsies were taken from MTTs and examined histopathologically and the sera of the patients’ and control groups were tested for both CEA and CA19-9, the patients’ group was tested twice, preoperatively and post operatively.
Results: Papillary thyroid carcinoma (PTC) was the most common MTT [n=46, (92%)]. Neck swelling was the most frequent (89.1%) feature among PTC patients. For the patients’ group, the median serum CEA results preoperatively was 1.57 (1.08-2.30) ng/ml, then it became 1.57 (0.94-2.05) ng/ml postoperatively, while the median preoperative serum CA19-9 was 12.17 (6.50-18.68) U/ml, then it became 12.24 (6.57-20.11) U/ml postoperatively; for both tumor markers, the differences between preoperative and postoperative concentrations were statistically significant (<0.05). The differences between median CEA concentrations between patients’ group and control group were statistically significant (p=0.001); while for CA 19-9 were statistically non-significant (p=0.936). Histologically, 97.92% of the differentiated thyroid tumors were in stage I.
Conclusion: There is significant decline in CEA concentration postoperatively among papillary thyroid carcinoma patients, while CA 19-9 was significantly increased postoperatively. The CEA concentration is higher in MTTs than in normal population and there is non-significant difference in CA 19-9 concentrations in MTTs and in normal population.

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