Assessment of Quality of life in irritable bowel syndrome patients and detecting the factors that are associated with QoL in Thi-Qar- Iraq

Main Article Content

Suha Nadem Muhsin
Alyaa Abdalrazaq Abass
Makarim M. Ali Hassan

Keywords

Anxiety, Irritable bowel syndrome, gender, Quality of life

Abstract

Background: Patients with irritable bowel syndrome have significantly worse quality of life (QOL) in contrast with the predominant community, and QOL is a typical measure of outcomes in treatment trials, cost effectiveness analysis, and clinical practice. The goals of this research were to: employing a 34-item self-report questionnaire, we analyzed QOL in IBS subtypes in a group of Iraqi patients, and identify the elements that are inversely related to quality of life in this patient population. Methods: Between February and September of 2022, a cross-sectional research was conducted on 80 patients with IBS who were all aged 18 or older, with a mean ( SD) age of 38.89 ( 13.16) years. Laboratory tests, a physical examination, and the patient's history were used to identify gastrointestinal disorders. Rome-3 criteria were used to divide sufferers into three groups: those that are irritable bowel syndrome with constipation (IBS-C), those that are irritable bowel syndrome with diarrhea (IBS-D), and those that are irritable bowel syndrome with mixed symptoms (IBS-M). QOL is measured using a self-report questionnaire, anxiety with the (Stait-trait anxiety assessment), and depression with the Beck depression inventory.
Results: There was no significant difference between the mixed subtype of IBS (2.68± 0.29), the constipation predominant subtype (2.83± 0.23), and the diarrhea predominant subtype (2.71± 0.27 ) in terms of mean QOL ratings (P value: 0.05). Severity of anxiety symptoms was inversely associated with QOL. There was a negative correlation between age [Standardized beta: 0.138, (95% confidence interval: -1.006, -4.518) and QOL scores, [Standardized beta: 0.753, (95% confidence interval: 0.365, 0.557)]. The probability is less than zero .05]
Conclusion: QOL was not difference between IBS subtyps and the other it was independently associated with Anxiety and gender while the ages, depression symptom, IBS subtypes, geographic distribution, educational, and marital status didn't have any relate to QOL.

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References

1. Adriani, Alessandro, et al. "Irritable bowel syndrome: the clinical approach." Panminerva Medica 60.4 (2018): 213-222.
2. Jamali, R., Jamali, A., Poorrahnama, M., Omidi, A., Jamali, B., Moslemi, N., ... & Ebrahimi Daryani, N. (2012). Evaluation of health related quality of life in irritable bowel syndrome patients. Health and Quality of Life Outcomes, 10(1), 1-6.
3. Trindade, Inês A., et al. "Quality of life in irritable bowel syndrome: Exploring mediating factors through structural equation modelling." Journal of Psychosomatic Research 159 (2022): 110809.
4. Melchior, C., Colomier, E., Trindade, I. A., Khadija, M., Hreinsson, J. P., Törnblom, H., & Simrén, M. (2022). Irritable bowel syndrome: Factors of importance for disease‐specific quality of life. United European Gastroenterology Journal.
5. Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B., & Mayer, E. A. (2000). The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology, 119(3), 654-660.
6. Brandt, L. N., Schoenfeld, P., Prather, C., Quigley, E., Schiller, L., & Talley, N. (2005). American College of Gastroenterology Functional Gastrointestinal Disorders Task Force. An evidence based approach to the management of chronic constipation in North America. Am. J. Gastroenterol, 100, 1-21.
7. Spiegel, B. M., Gralnek, I. M., Bolus, R., Chang, L., Dulai, G. S., Mayer, E. A., & Naliboff, B. (2004). Clinical determinants of health-related quality of life in patients with irritable bowel syndrome. Archives of internal medicine, 164(16), 1773-1780.
8. Faresjö A, Anastasiou F, Lionis C, Johansson S, Wallander MA, Faresjö T: Health-related quality of life of irritable bowel syndrome patients in different cultural settings. Health Qual Life Outcomes 2006, 4:21.
9. Kovacs Z, Kovacs F: Depressive and anxiety symptoms, dysfunctional attitudes and social aspects in irritable bowel syndrome and inflammatory bowel disease. Int J Psychiatry Med 2007, 37:245-255.
10. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC: Functional bowel disorders. Gastroenterology 2006, 130:1480-1491.
11. Minguez Perez M, Benages Martinez A: The Bristol scale - a useful system to assess stool form? Rev Esp Enferm Dig 2009, 101:305-311.
12. Patrick DL, Drossman DA, Frederick IO, DiCesare J, Puder KL: Quality of life in persons with irritable bowel syndrome: development and validation of a new measure. Dig Dis Sci 1998, 43:400-411.
13. Richter P, Werner J, Heerlein A, Kraus A, Sauer H: On the validity of the Beck Depression Inventory. A review. Psychopathology 1998, 31:160-168.
14. Beck AT, Steer RA, Ball R, Ranieri W: Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess 1996, 67:588-597.
15. Carey, Michael P., Michael E. Faulstich, and Tracy C. Carey. "Assessment of anxiety in adolescents: concurrent and factorial validities of the Trait Anxiety scale of Spielberger's State-Trait Anxiety Inventory for Children." Psychological reports (1994).
16. Katsinelos P, Lazaraki G, Kountouras J, Paroutoglou G, Oikonomidou I,
17. Mimidis K, Koutras C, Gelas G, Tziomalos K, Zavos C, Pilpilidis I, Chatzimavroudis G: Prevalence, bowel habit subtypes and medical careseeking behaviour of patients with irritable bowel syndrome in Northern Greece. Eur J Gastroenterol Hepatol 2009, 21:183-189.
18. Ma, Kai, et al. "Brain functional interaction of acupuncture effects in diarrhea-dominant irritable bowel syndrome." Frontiers in Neuroscience 14 (2020): 608688.
19. Balmus, Ioana-Miruna, et al. "Irritable bowel syndrome and neurological deficiencies: is there a relationship? The possible relevance of the oxidative stress status." Medicina 56.4 (2020): 175.
20. Cassar, Gillian E., et al. "Health-related quality of life in irritable bowel syndrome: a systematic review and meta-analysis." Gastroenterology nursing 43.3 (2020): E102-E122.
21. Singh P, Staller K, Barshop K, Dai E, Newman J, Yoon S, Castel S, Kuo B. Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation. World J Gastroenterol. 2015 Jul 14;21(26):8103-9. doi: 10.3748/wjg.v21.i26.8103. PMID: 26185382; PMCID: PMC4499353.
22. Katsinelos P, Lazaraki G, Kountouras J, Paroutoglou G, Oikonomidou I, Mimidis K, Koutras C, Gelas G, Tziomalos K, Zavos C, Pilpilidis I, Chatzimavroudis G: Prevalence, bowel habit subtypes and medical care seeking behaviour of patients with irritable bowel syndrome in Northern Greece. Eur J Gastroenterol Hepatol 2009, 21:183-189.
23. Jerndal P, Ringström G, Agerforz P, Karpefors M, Akkermans LM, Bayati A, Simrén M: Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS. Neurogastroenterol Motil 22:646-e179.
24. Simrén M, Abrahamsson H, Svedlund J, Björnsson ES. Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel pattern. Scand J Gastroenterol. 2001 May;36(5):545-52. doi: 10.1080/003655201750153476. PMID: 11346211.
25. Kim YS, Kim N. Sex-Gender Differences in Irritable Bowel Syndrome. J Neurogastroenterol Motil. 2018 Oct 1;24(4):544-558. doi: 10.5056/jnm18082. PMID: 30347934; PMCID: PMC6175559.
26. Mohebbi, Zinat, et al. "Effect of Hypnotism on the Severity of Gastrointestinal Symptoms and Quality of Life in Individuals With Irritable Bowel Syndrome." Journal of Psychosocial Nursing and Mental Health Services 60.5 (2022): 55-62.