Clinical characteristics and complications of kidney transplantation among an Egyptian pediatric cohort
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Keywords
kidney transplantation, pediatric, complications
Abstract
Background: kidney transplantation is the treatment of choice in children with end stage kidney disease. Acute rejection represents a major complication with high risk of graft loss. Hence, the use of immunosuppressive therapy is inevitable to prevent allograft rejection. However, the excess use of immunosuppressive drugs can increase the risk of post-transplant infections with higher morbidity and mortality. The judicious use of the immunosuppressive drugs is crucial to enhance the transplant outcomes. Tacrolimus is the backbone of immunosuppressive therapy in the recent era of kidney transplantation. However, it is associated with many side effects. Close clinical and laboratory monitoring of tacrolimus trough level and serum creatinine are essential in all patients.
Methods: Analysis of the clinical data of 83 kidney transplant recipients with follow up data as graft function, post-transplant complications as acute rejection and infections were documented. Tacrolimus adverse effects were reported during at least 36 months of follow up post-transplant.
Results: Acute rejection was encountered in 43.4 % and post-transplant infections in 41 % of the included cases in the current study. In addition, tacrolimus side effects occurred in 32.5 % of the cases.
Conclusion: close follow up of kidney transplant recipients is essential for early detection and prompt management of graft rejection and infectious complications.
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