Pathophysiological Detection of Alpha-Fetoprotein in Iraqi Women with Polycystic Ovarian Syndrome

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Hajras Shaker Saleh
Iqbal A. AlRufaei
Enass Saleh Jawad


Alpha-Fetoprotein, Polycystic Ovary Syndrome, Diagnostic, Iraqi women


Polycystic ovary syndrome (PCOS), is one of the most common endocrinpathies in premenopausal women, which has been reclassified as a reproductive and metabolism disorder after the recognition of the important role of insulin resistance in the pathophysiology of the syndrome. Current surveillance strategy for patients with polycystic ovary syndrome at risk of nonalcoholic fatty liver disease
development is unsatisfactory. We aimed to investigate the diagnostic accuracy of alpha-fetoprotein (AFP). Moreover, existing data support that androgen excess, which existing data support that androgen excess, which is the main feature of PCOS and is interrelated to insulin resistance, may be an additional contributing factor to the development of non-alcoholic fatty liver disease (NAFLD).
The biomarker (AFP) was investigated in group of PCOS women (75) and group control (50). AFP showed higher in patients with PCOS (80 ± 0.22) compared to control group (0.67 ± 0.19) at p. value < 0.05. The results also showed a significant increase of AFP in PCOS women than control in all BMI categories with except normal weight was not scored significant difference at p. value < 0.05. The serum AFP levels estimated relationship between fatty liver disease and PCOS can effectively improve the diagnostic performance of PCOS, providing a new indicator that is simple, economical and pervasive for clinic.

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