“STUDY OF THROMBOCYTOPENIA AMONG CASES OF NEONATAL SEPSIS”
Main Article Content
Keywords
Neonatal sepsis; Thrombocytopenia; Platelet count; Serial platelet monitoring; Neonatal septicemia; Klebsiella pneumoniae; Mortality; Platelet transfusion; Blood culture; Neonatal intensive care unit.
Abstract
Thrombocytopenia is frequently associated with neonatal septicemia. In view of higher incidence of thrombocytopenia in neonatal sepsis, the serial platelet count should be done routinely in all cases of neonatal septicemia.
Aims and objectives: Study of thrombocytopenia among cases of Neonatal Sepsis
Methodology: 190 neonates with inclusion criteria taken for study from 21/03/18 to 31/04/19 in our NICU. Initial platelet count (day1) was recorded and was followed by on day 3, 6 , 9 (and as on when necessary) till the count reached the normal limit. Neonatal data like gender, gestational age, birth weight, occurrence of haemorrhage, use of platelet transfusion, blood investigations, length of hospital stay and neonatal mortality was recorded.Results of analysis and statistical data were recorded and presented in formulated tables.
Results: Thrombocytopenia was seen in 77.9% of septic neonates. Very Severe degree of thrombocytopenia was seen in 12.11% of septic neonates. The decreasing trend in the platelet count showed significant mortality (p value <0.05). In cases of mortality, 6 cases (13.95%) had very severe degree of thrombocytopenia.
Conclusion: In this study, we concluded that there was high incidence of thrombocytopenia in neonatal sepsis (77.9%). Klebsiella pneumoniae (38%) was the most common pathogen isolated in the blood culture. There was significant increase in the hospital stay in neonatal septicaemia in culture positive cases (p value<0.05).On comparing serial platelet count it was found that, serial platelet was in a decreasing trend in neonates who had mortality. (p value<0.05), and in an increasing trend in the platelet count showed decreased mortality(p value<0.05).Hence, serial thrombocytopenia monitoring is necessary in neonatal sepsis.
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31. Tallur SS,Kastur AV,Nadgir SD,Tallur SS.Clinicobacteriological study of neonatal septicemia in Hubli,Indian J pediatr 2000;67(3):169-174
32. Philip AGS and Hewitt JR.Early diagnosis of neonatal sepsis, Pediatric 1980;65(5):1036-41
33. Benitz WE,Han MY,Madan A,Ramachandra P.Serial Serum C-Reactive Proteinlevels in the Diagnosis of Neonatal Infection,pediatrics 1998;102(4):41-45
34. Deodhar S.C-Reactive Protein;The Best Laboratory Indicator Available for Monitoring Disease Activity, Cleve clin J 1989;56:126-130
35. Horns K.M.Neoteric Physiologic and Immunologic methods for Assessing Early – Onset Neonatal Sepsis, J Perinat Neonat Nurs 2000;13(4):50-66
36. Yentis SM,Soni N,Sheldon J.C-Reactive Protein as an Indicator of Resolution of Sepsis in the Intensive Care Med 1995;21:602-605
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38. Greer JP,Foerster J,Lukens JN.Miscellaneous Causes Of Thrombocytopenia, Chapter 55,Wintrobe clinical Hematology 10th edition,Levine SP,Williams and Willkins,Volume 2 phildelphia 2004;1569-1570
39. Rodwell RL,Leslic AL,Tudehope DI.Early Diagnosis of Neonatal Sepsis using a Hematologic Scoring System, J.Pediatr: 1988;112:761-767
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Oct 27, 2025
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Dr. Vinay Kumar M, Dr Narendra, & Dr. S.S.Sarawade. (2025). “STUDY OF THROMBOCYTOPENIA AMONG CASES OF NEONATAL SEPSIS”. Journal of Population Therapeutics and Clinical Pharmacology, 32(10), 2402-2415. https://doi.org/10.69980/jy5dds96
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Author Biographies
Dr. Vinay Kumar M
Assistant Professor , Department Of Pediatrics ,MVJ Medical College and Research Institute
Dr Narendra
Pediatric Neurologist -Parijma Medical Centre and Rangadore Memorial Hospital, Bengaluru
Dr. S.S.Sarawade
Professor, Department Of Pediatrics Rajarshee Chhatrapati Shahu Maharaj, Government Medical College, Kolhapur. Email: [email protected]
How to Cite
Dr. Vinay Kumar M, Dr Narendra, & Dr. S.S.Sarawade. (2025). “STUDY OF THROMBOCYTOPENIA AMONG CASES OF NEONATAL SEPSIS”. Journal of Population Therapeutics and Clinical Pharmacology, 32(10), 2402-2415. https://doi.org/10.69980/jy5dds96
