EFFECTS OF VITAMIN D SUPPLEMENTATION ON UTERINE FIBROID–RELATED HEAVY MENSTRUAL BLEEDING
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Keywords
Uterine fibroid, leiomyoma, vitamin D, heavy menstrual bleeding.
Abstract
Objective: To evaluate the association between vitamin D deficiency and heavy menstrual bleeding in women with uterine fibroids and to determine the therapeutic effect of vitamin D supplementation alongside conventional therapy.
Methods: This randomized controlled interventional study was conducted at the Department of Pharmacology, BMSI, in collaboration with the Department of Obstetrics and Gynecology, Jinnah Postgraduate Medical Centre (JPMC), Karachi. A total of 111 premenopausal women (30–50 years) diagnosed with uterine fibroids (3–13 cm) were enrolled. Serum vitamin D levels were assessed, and transvaginal ultrasonography (TVS) was performed. Vitamin D–deficient patients received oral vitamin D supplementation (50,000 IU/week) in combination with tranexamic acid (500 mg) and dydrogesterone (10 mg) for 24 weeks. Pre- and post-intervention comparisons were performed using a paired t-test (p ≤ 0.01).
Results: Among 111 patients, 81 (73%) were vitamin D deficient. Heavy menstrual bleeding was present in 95 patients. After 90 days, mean serum vitamin D levels significantly increased (22.56 ± 8.25 to 40.25 ± 7.48 ng/mL; p=0.001), while mean fibroid size significantly decreased (8.43 ± 1.95 cm to 3.55 ± 1.30 cm; p=0.001).
Conclusion: Vitamin D supplementation significantly improved serum vitamin D levels, reduced fibroid size, and decreased heavy menstrual bleeding. Vitamin D may serve as a safe, noninvasive adjunct therapy in women with uterine fibroids.
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Dr Nida Ayesha
Assistant Professor, Pharmacology Department, Jinnah Sindh Medical University
Dr Farah Asad
prof, Pharmacology Department, Jinnah Sindh Medical University
Dr Salahuddin Qureshi
prof, Pharmacology Department, Jinnah Sindh Medical University
Dr Nadia Naeem
Assistant Professor, Pharmacology Department, Jinnah Sindh Medical University
Dr Mohammad Azhar Mughal
prof, Pharmacology Department, Jinnah Sindh Medical University
Dr Fayaz Ahmed
Senior Register, Anesthesia Department, Liaquat National Medical Hospital
