FREQUENCY AND FACTORS IN NEONATAL PNEUMONIA AND ITS COMPLICATIONS IN ADMITTED ICU PATIENTS OF TERTIARY CARE HOSPITAL OF PESHAWAR. A CROSS-SECTIONAL ANALYTICAL STUDY
Main Article Content
Keywords
Neonatal pneumonia, Prematurity, NICU, Complications
Abstract
Background :Neonatal pneumonia is one of the leading causes of neonatal morbidity and mortality in neonatal intensive care units, particularly in developing countries. Some of the known factors include maternal infection, low birth weight, and premature birth. Early identification of associated risk factors and complications can increase the chance of surviving as a neonate and having a better clinical outcome.
Objective:To find out the prevalence of neonatal pneumonia, factors, and complications of the neonates who were admitted to the ICU of a tertiary care hospital in Peshawar.
Methodology:The study was cross-sectional and analytical in the Neonatal Intensive Care Unit of a tertiary care hospital in Peshawar for six months. One hundred neonatal cases aged 0-28 days with clinical and radiological signs of pneumonia were recruited using a non-probability consecutive sampling. A structured proforma was used to obtain the data on the demographic characteristics, maternal and neonatal risk factors, and complications. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 26. Quantitative variables were analyzed using mean ± standard deviation, and qualitative variables were analyzed using frequency and percentage. The data were analyzed by the Chi-Square test, and a p-level of < 0.05 was regarded as statistically significant.
Result:The mean age of neonates was 12.4 ± 6.2 days. Male neonates accounted for 61% of cases, while 56% were preterm and 63% had low birth weight. Prolonged rupture of membranes was present in 35% of mothers, and mechanical ventilation was required in 29% of neonates. Prolonged hospital stay (40%) and sepsis (31%) were the most common complications. Mortality was observed in 17% of patients. Prematurity and low birth weight showed significant association with adverse outcomes (p=0.02 and p=0.03 respectively).
Conclusion:Neonatal pneumonia is also a serious complication and cause of death in the neonate admitted to the NICU. Prematurity and low weight are significant risk factors for poor outcomes. Early diagnosis and enhanced neonatal care can bring down the burden of disease and death.
References
2. Yang SM, Liu Y, Liu C, Yin AH, Wu YF, Zheng XE, Yang HM, Yang J. Hearing-loss-associated gene detection in neonatal intensive care unit. J Matern Fetal Neonatal Med. 2018 Feb;31(3):284-288. doi: 10.1080/14767058.2017.1282454.
3. Yun ZY, Dong LJ, Fu W, Peng YQ, Wang YH, Yu YP, Shen BY. [An analysis of various diseases and hearing screening in NICU infants]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jul 20;30(14):1134-1136. Chinese. doi: 10.13201/j.issn.1001-1781.2016.14.011.
4. Brooks B, Olm MR, Firek BA, Baker R, Thomas BC, Morowitz MJ, Banfield JF. Strain-resolved analysis of hospital rooms and infants reveals overlap between the human and room microbiome. Nat Commun. 2017 Nov 27;8(1):1814. doi: 10.1038/s41467-017-02018-w.
5. Sammons JS, Graf EH, Townsend S, Hoeg CL, Smathers SA, Coffin SE, Williams K, Mitchell SL, Nawab U, Munson D, Quinn G, Birenbaum G. Outbreak of Adenovirus in a Neonatal Intensive Care Unit: Critical Importance of Equipment Cleaning During Inpatient Ophthalmologic Examinations. Ophthalmology. 2019 Jan;126(1):137-143. doi: 10.1016/j.ophtha.2018.07.008.
6. Yap PS, Ahmad Kamar A, Chong CW, Yap IK, Thong KL, Choo YM, Md Yusof MY, Teh CS. Intestinal carriage of multidrug-resistant gram-negative bacteria in preterm-infants during hospitalization in neonatal intensive care unit (NICU). Patho Glob Health. 2016 Sep;110(6):238-246. doi: 10.1080/20477724.2016.1229884.
7. Liao N, Luo J, Zhou X, Qin J. [Therapeutic effect of one-day outpatient on gestational diabetes mellitus patients]. Zhong Nan Da Xue Bao Yi Xue Ban. 2017 Aug 28;42(8):966-972. Chinese. doi: 10.11817/j.issn.1672-7347.2017.08.015.
8. Yusef D, Shamakhi T, Awad S, Algaroba H, Khazanah W. Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug-resistant organisms: A retrospective review. Pediatric Neonatol. 2018 Feb;59(1):35-41. doi: 10.1016/j.pedneo.2017.06.001.
9. Lu L, Yan Y, Yang B, Xiao Z, Feng X, Wang Y, Ji W, Mize M, Hao C, Chen Z. Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China. BMC Infect Dis. 2015 Oct 15; 15:431. doi: 10.1186/s12879-015-1155-x.
10. Vayalthrikkovil S, Vorhies E, Stritzke A, Bashir RA, Mohammad K, Kamaluddeen M, Thomas S, Al Awad E, Murthy P, Sora Isham A. Prospective study of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Pediatric Pulmonol. 2019 Feb;54(2):171-178. doi: 10.1002/ppul.24211.
11. Das I, Das RN, Paul B, Mandal B, Mukherjee S, Chatterjee U. A study of spectrum of pulmonary pathology and expression of thyroid transcription factor-1 during neonatal period. Indian J Patho Microbiol. 2018 Jul-Sep;61(3):334-338. doi: 10.4103/IJPM.IJPM_650_17.
12. Kurek Eken M, Tuten A, Oz kaya E, Dinçer E, Şenol T, Karate kin G, Karateka A. Evaluation of the maternal and fetal risk factors associated with neonatal care unit hospitalization time. J Matern Fetal Neonatal Med. 2016 Nov;29(21):3553-7. doi: 10.3109/14767058.2016.1138466.
13. Chen SW, Fu W, Liu J, Wang Y. Routine application of lung ultrasonography in the neonatal intensive care unit. Medicine (Baltimore). 2017 Jan;96(2): e5826. doi: 10.1097/MD.0000000000005826.
14. Ibrahim M, Omran A, Abdallah NB, Ibrahim M, El-Sharkey S. Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress. J Neonatal Perinatal Med. 2018;11(3):281-287. doi: 10.3233/NPM-181796.
15. Chiu Chetta FS, Munhoz TN, Santos IS, Menezes AM, Albernaz E, Barros FC, Matijevic A. Neonatal ventilatory support and respiratory diseases in children up to six years of age: the 2004 Pelotas (Brazil) Birth Cohort study. Cad Saude Publica. 2015 Jul;31(7):1403-15. English, Portuguese. doi: 10.1590/0102-311X00087614.
16. Cagan E, Kirya Baş E, Asker HS. Use of Colistin in a Neonatal Intensive Care Unit: A Cohort Study of 65 Patients. Med Sci Monit. 2017 Jan 30; 23:548-554. doi: 10.12659/msm.898213.
17. Cantey JB, Wozniak PS, Pruszynski JE, Sánchez PJ. Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study. Lancet Infect Dis. 2016 Oct;16(10):1178-1184. doi: 10.1016/S1473-3099(16)30205-5.
18. Rodríguez-Fanjul J, Bal cells C, Aldecoa-Bilbao V, Moreno J, Irion do M. Lung Ultrasound as a Predictor of Mechanical Ventilation in Neonates Older than 32 Weeks. Neonatology. 2016;110(3):198-203. doi: 10.1159/000445932.
19. Zhou F, Ning H, Chen F, Wu W, Chen A, Zhang J. Burkholderia gladioli infection isolated from the blood cultures of newborns in the neonatal intensive care unit. Eury J Clin Microbial Infect Dis. 2015 Aug;34(8):1533-7. doi: 10.1007/s10096-015-2382-1.
20. Thakur S, Thakur K, Sood A, Chaudhary S. Bacteriological profile and antibiotic sensitivity pattern of neonatal septicemia in a rural tertiary care hospital in North India. Indian J Med Microbial. 2016 Jan-Mar;34(1):67-71. doi: 10.4103/0255-0857.174108.

