ASSOCIATION OF TELOMERASE ACTIVITY WITH OXIDATIVE STRESS AND ENDOTHELIAL FUNCTION IN PREHYPERTENSION.
Main Article Content
Keywords
Prehypertension, Telomerase activity, Oxidative stress, Endothelial dysfunction, Vascular aging, Endothelin-1.
Abstract
Background: Prehypertension is an early blood pressure phenotype associated with increased cardiovascular risk; however, its cellular and vascular mechanisms in young adults remain incompletely defined. This study evaluated telomerase activity, oxidative stress, and endothelial function biomarkers in young adults with prehypertension compared to normotensive controls.
Methods: This analytical cross-sectional study included 91 young adults, comprising 47 normotensive controls and 44 individuals with prehypertension, classified according to the JNC 7 blood pressure criteria. Anthropometric parameters and blood pressure were measured using standardized methods. Serum telomerase activity, thiobarbituric acid reactive substances (TBARS), vascular cell adhesion molecule (VCAM), endothelin-1 (ET-1), soluble E-selectin, vascular endothelial growth factor (VEGF), and resistin levels were assessed. Between-group comparisons were performed using appropriate parametric and non-parametric tests. The correlations between telomerase activity, oxidative stress, and endothelial biomarkers were evaluated.
Results: Age and height were comparable between the groups. Prehypertensive participants had significantly higher body weight, body mass index, systolic blood pressure, and diastolic blood pressure than those of the controls. Compared with normotensive controls, the prehypertensive group showed significantly higher VCAM, ET-1, TBARS, telomerase activity, resistin, soluble E-selectin, and VEGF levels and lower NO levels. Telomerase activity was strongly positively correlated with VCAM, ET-1, VEGF, resistin, and soluble E-selectin levels. TBARS levels were also positively correlated with VCAM, ET-1, VEGF, and telomerase activity.
Conclusion: Young adults with prehypertension demonstrate a coordinated oxidative–endothelial–cellular stress phenotype characterized by elevated oxidative stress, endothelial activation, inflammatory vascular biomarkers, angiogenic response, and altered telomerase activity. Longitudinal studies are required to determine whether these biomarkers can predict the progression to established hypertension.
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Bandi Hari Krishna
Assistant Professor of Physiology, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
Madhusudhana Pulaganti
Research Scientist, Multidisciplinary Research Unit, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
Anantha Soma Kireeti
Nodal Officer, Multidisciplinary Research Unit, and Professor of Pediatrics, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
