CORRELATION OF DASHAVIDHA PARIKSHA WITH SPECIFIC PRO-INFLAMMATORY CYTOKINE PROFILES IN PATIENTS WITH RHEUMATOID ARTHRITIS (AMAVATA )

Abstract

Rheumatoid Arthritis (RA), clinically correlated with Amavata  is a chronic autoimmune syndrome characterized by persistent synovial inflammation and systemic immune dysregulation. While modern rheumatology utilizes objective biomarkers, Ayurveda employs the Dashavidha Pariksha (Tenfold Examination) for comprehensive patient phenotyping. This study analyzes the correlation between the ten parameters Prakriti, Vikriti, Sara, Samhanana, Pramana, Satmya, Satva, Ahara Shakti, Vyayama Shakti, and Vaya and the systemic titers of pro-inflammatory cytokines, specifically Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and Interleukin-1 (IL-1).[i] Evidence suggests that Vata -predominant Prakriti and high-degree Vikriti scores are associated with elevated TNF-α and IL-6 levels. Furthermore, parameters like Satva and Ahara Shakti demonstrate significant correlations with the neuro-endocrine-immune axis and gut-microbiota-driven inflammation. Integrating these ancient diagnostic metrics provides a robust framework for personalized medicine and patient-centric prognosis in autoimmune pathology.