CORRELATION OF VISCERAL ADIPOSITY INDICES AND HEPATIC STEATOSIS VIA ULTRASONOGRAPHY WITH METABOLIC SYNDROME RISK: A CROSS-SECTIONAL MULTI-CENTER STUDY IN INDUSTRIAL URBAN POPULATIONS

Main Article Content

Dr. Maushumi Barthakur
dr. Chaudhary Milan
dr. Sumithra Bongu

Keywords

Visceral Adiposity Index, Hepatic Steatosis, Ultrasonography, Metabolic Syndrome, Industrial Health.

Abstract

Background: The rising prevalence of metabolic syndrome (MetS) in industrial urban centers presents a significant public health challenge. While Body Mass Index (BMI) is a common metric, it often fails to distinguish between subcutaneous and visceral fat. This study investigates the correlation between specific Visceral Adiposity Indices (VAI), the presence of Hepatic Steatosis (HS) detected via ultrasonography, and the overall risk of MetS.


Methods: A cross-sectional, multi-center study was conducted across tertiary healthcare centers in Durgapur and Ahmedabad. A total of 450 adult participants were screened. Physiological assessments included blood pressure, lipid profiles, and fasting glucose levels to determine MetS status according to NCEP-ATP III criteria. Anthropometric data were used to calculate VAI. Radio-diagnosis specialists performed transabdominal ultrasonography to grade hepatic steatosis (Non-Alcoholic Fatty Liver Disease).


Results: Preliminary findings indicate a strong positive correlation (r > 0.65, p < 0.001) between elevated VAI and the severity of hepatic steatosis. Subjects with Grade II and III steatosis exhibited a significantly higher incidence of hypertension and dyslipidemia compared to those with normal liver echoes. Furthermore, VAI demonstrated higher sensitivity in predicting metabolic risk than traditional BMI measurements within this industrial cohort.


Conclusion: Integrating physiological markers with radiological screening provides a more robust framework for early MetS detection. The high prevalence of hepatic steatosis in these regions suggests that ultrasonography should be considered a routine screening tool for at-risk urban populations to mitigate long-term cardiovascular and metabolic complications.


 

Abstract 0 | Pdf Downloads 0

References

1. Amato, M. C., et al. (2010). "Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk." Diabetes Care, 33(4), 920-922. (The foundational paper for VAI calculation).
2. Amato, M. C., & Giordano, C. (2014). "Visceral Adiposity Index: an indicator of adipose tissue dysfunction." European Journal of Clinical Nutrition, 68(6), 634-640.
3. Knowles, K. M., et al. (2011). "Visceral Adiposity Index: A potential surrogate for visceral fat in children and adolescents." Metabolic Syndrome and Related Disorders, 9(6), 445-450.
4. Vaisman, N., et al. (2012). "Visceral adiposity index is a better predictor of liver fat content than Body Mass Index." Clinical Nutrition, 31(6), 901-905.
5. Ji, B., et al. (2016). "The Visceral Adiposity Index is associated with Non-alcoholic Fatty Liver Disease in Chinese Adults." Scientific Reports, 6, 26585.
6. Misra, A., & Khurana, L. (2009). "The metabolic syndrome in South Asians: epidemiology, determinants, and management." Metabolic Syndrome and Related Disorders, 7(6), 497-514.
7. Misra, A., et al. (2009). "Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and dietary management." Journal of the Association of Physicians of India, 57, 163-170.
8. Alberti, K. G., et al. (2009). "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention." Circulation, 120(16), 1640-1645.
9. Enas, E. A., et al. (2007). "The metabolic syndrome and dyslipidemic hyperinsulinemia in Asian Indians: a population-at-risk." Journal of the Association of Physicians of India, 55, 224-232.
10. Gupta, R., et al. (2012). "Trends in prevalence of coronary heart disease and risk factors over 60 years in India." Indian Heart Journal, 64(3), 274-281.
11. Farrell, G. C., & Larter, C. Z. (2006). "Nonalcoholic fatty liver disease: from steatosis to steatohepatitis." Hepatology, 43(S1), S99-S112.
12. Saadeh, S., et al. (2002). "The utility of real-time B-mode ultrasonography in the diagnosis of hepatic steatosis." Gastroenterology, 123(3), 745-750. (Crucial for the Radio-diagnosis methodology).
13. Hernaez, R., et al. (2011). "Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis." Hepatology, 54(3), 1082-1090.
14. Dasarathy, S., et al. (2009). "Validity of real time ultrasound in the diagnosis of hepatic steatosis: a multi-observer study of 133 liver biopsies." European Journal of Radiology, 70(3), 529-534.
15. Duseja, A., et al. (2007). "Non-alcoholic fatty liver disease (NAFLD) is extremely common in the North Indian anomalies of metabolic syndrome." Journal of Gastroenterology and Hepatology, 22(8), 1214-1217.
16. Prabhakaran, D., et al. (2005). "Cardiovascular risk factors for coronary heart disease in two industrial populations in India." Journal of the American College of Cardiology, 45(1), 67-73.
17. Reddy, K. S., et al. (2006). "Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations." Bulletin of the World Health Organization, 84(6), 461-469.
18. Ahmad, J., et al. (2012). "Prevalence of metabolic syndrome in an industrial population of North India." Indian Journal of Endocrinology and Metabolism, 16(6), 954-960.
19. Shah, N. S., et al. (2015). "Urbanization and the epidemiology of non-communicable diseases in South Asia." The Lancet Global Health, 3(8), e444-e445.
20. Yudkin, J. S., et al. (1999). "Inflammation, obesity, insulin resistance and coronary heart disease: is there a common link?" Atherosclerosis, 145(2), 209-214.