ASSOCIATION OF VITAMIN D STATUS WITH THYROID FUNCTION AND BIOCHEMICAL PARAMETERS IN NEWLY DIAGNOSED PRIMARY HYPOTHYROIDISM: A CASE–CONTROL STUDY.
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Keywords
Hypothyroidism, Vitamin D deficiency, Thyroid function, Anti-TPO antibodies, Case–control study
Abstract
Background:Vitamin D plays an important role in immune modulation and endocrine regulation. Deficiency has been associated with autoimmune thyroid disorders and altered metabolic parameters. Data from Indian populations remain limited.
Objective:To assess serum vitamin D levels in newly diagnosed primary hypothyroidism and evaluate their association with thyroid function and biochemical parameters.
Methods:A hospital-based case–control study was conducted including 50 patients with newly diagnosed primary hypothyroidism and 50 age- and sex-matched healthy controls. Serum FT3, FT4, TSH, vitamin D, anti-TPO antibodies, and calcium were measured. Statistical analysis included comparison of means and correlation analysis.
Results:Mean serum vitamin D levels were significantly lower in cases (18.50 ± 12.20 ng/ml) compared to controls (37.14 ± 16.90 ng/ml) (p<0.001). FT3 and FT4 levels were significantly lower, while TSH and anti-TPO antibody levels were significantly higher in cases. Correlation analysis showed a weak positive correlation between vitamin D and FT3 (r = 0.134, p>0.05) and a moderate positive correlation between vitamin D and serum calcium (r = 0.494, p<0.05).
Conclusion:Vitamin D deficiency is highly prevalent in hypothyroid patients and is associated with altered thyroid function and calcium metabolism. Screening and correction of deficiency may have clinical benefits.
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Dr. Guru Kumar Sain
Associate Professor, Department of General Medicine, Govt. Medical College, Dungarpur.
Dr. Ajesh Kumar Damor
Associate Professor, Department of General Medicine, Govt. Medical College, Dungarpur.
Dr. Ajit Kumar Roat
Assistant Professor, Department of General Medicine, Govt. Medical College, Dungarpur.
Dr. Ankit Bhagora
Assistant Professor, Department of CommunityMedicine, Govt. Medical College, Dungarpur
