A COMPARATIVE STUDY OF ADIPOKINE PROFILES IN DIABETIC AND NON-DIABETIC INDIVIDUALS WITH A HISTORY OF SUBSTANCE ABUSE
Main Article Content
Keywords
Adipokines, diabetes mellitus, substance abuse, adiponectin, leptin, resistin
Abstract
Background: Adipokines play crucial roles in glucose homeostasis and metabolic regulation. The concurrent presence of diabetes and substance abuse may create unique metabolic perturbations affecting adipokine profiles. This study aimed to compare adipokine levels between diabetic and non-diabetic individuals with substance abuse history.
Methods: A comparative cross-sectional study was conducted at Maa Vindhyawasini Autonomous State Medical College, Mirzapur, from January to August 2025. One hundred participants with documented substance abuse history were enrolled: 50 with type 2 diabetes and 50 non-diabetic controls. Serum adiponectin, leptin, and resistin levels were measured using ELISA. Clinical parameters, anthropometric measurements, and substance abuse patterns were assessed.
Results: Diabetic participants showed significantly lower adiponectin levels (4.8±2.6 vs 9.2±3.8 μg/ml, p<0.001) and higher leptin (14.6±8.4 vs 8.8±5.2 ng/ml, p<0.001) and resistin levels (18.4±6.8 vs 12.6±4.2 ng/ml, p<0.001) compared to non-diabetic individuals. The leptin-to-adiponectin ratio was 3.2-fold higher in diabetic participants (3.8±2.1 vs 1.2±0.8, p<0.001). Strong correlations were observed between adipokine levels and metabolic parameters including BMI, HbA1c, and HOMA-IR. Multiple regression analysis identified diabetes status, BMI, and substance abuse duration as independent predictors of adipokine alterations.
Conclusion: Individuals with concurrent diabetes and substance abuse demonstrate profound adipokine dysregulation characterized by severe hypoadiponectinemia and elevated pro-inflammatory adipokines. These findings suggest heightened metabolic risk requiring targeted interventions and intensive monitoring in this vulnerable population.
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Dr. Jaipal Singh
Associate Professor, Department of Biochemistry, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, jaypaul88@gmail.com
Dr. Jitendra Kumar Singh
Assistant Professor, Department of Biochemistry, Autonomous State Medical College, Sonebhadra, jitendra.singh.3576224@gmail.com, Orcid id: 0009-0003-2230-3571
Dr. Barkha Chauhan
Assistant Professor, Department of Biochemistry, School of Medical Sciences and Research, Greater Noida, barkhachauhan06@gmail.com, U.P., Orcid id: 0009-0005-3498-5789
Dr. Ankit Singh
Assistant Professor, Department of Community Medicine, Autonomous State Medical College, Sonebhadra, ankitbiostat@gmail.com Orcid id: 0000-0001-9896-047X
