ASSOCIATION OF hs-CRP, Pro-BNP AND TROPONIN-I IN PATIENTS WITH CORONARY ARTERY DISEASE
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Keywords
hs-CRP, pro-BNP, Troponin-I, Coronary Artery Disease, Biomarkers, Inflammation.
Abstract
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality globally. Inflammatory and myocardial injury biomarkers such as high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-B-type natriuretic peptide (pro-BNP), and cardiac troponin-I have emerged as sensitive indicators of risk, severity, and clinical outcomes.
Aim: To assess the association of hs-CRP, pro-BNP, and troponin-I with the biochemical severity of CAD. Methods: A hospital-based cross-sectional study was conducted among 120 subjects—90 CAD patients and 30 age-matched healthy controls. Serum hs-CRP, plasma pro-BNP, and troponin-I were measured using chemiluminescence immunoassays. CAD patients were categorized according to angiographic severity. Results: All three biomarkers were significantly elevated in CAD patients compared to controls (p < 0.001). Levels increased proportionally with the severity of vessel involvement. A positive correlation was observed among hs-CRP, pro-BNP, and troponin-I, indicating a combined inflammatory–ischemic burden. Conclusion: hs-CRP, pro-BNP, and troponin-I together provide a strong biochemical profile for evaluating severity and risk in CAD patients.
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Dr. Ashish Chandna
Assistant Professor, Dept. of Biochemistry, Saraswati Medical College, Unnao, Email- chandnapath@gmail.com
