COMPARATIVE ANALYSIS OF BONE METABOLISM PARAMETERS IN LUNG CANCER PATIENTS
Main Article Content
Keywords
Lung cancer, Vitamin D, Calcium, Phosphorus, ALP, Bone parameters
Abstract
Background: Lung cancer is one of the growing health concerns worldwide due to its high prevalence. Diagnosis of the disease at an early stage may decrease the mortality associated and improve its prognosis. Vitamin D has been reported to have antioncogenic properties and estimation of its levels along with other parameters of bone metabolism may improve the diagnosis of lung cancer.
Methods: Serum levels of vitamin D, calcium, phosphorus and alkaline phosphatase (ALP) in patients with lung cancer before and after standard chemoradiation were estimated in 25 patients with lung cancer before and 4 weeks after standard treatment by chemoradiation. The levels were also analyzed in 25 apparently healthy controls and data was compared among different groups using appropriate statistical analysis.
Results: The levels of vitamin D in lung cancer patients were found to be statistically significantly altered as compared to controls and also after completion of treatment (p<0.05). The levels of ALP were also found to be statistically significantly decreased in patients as compared to controls (p<0.05) but the difference was not statistically significant in patients before and after treatment (p>0.05). Similarly, difference in serum calcium and phosphorus levels in different groups was also not statistically significant (p>0.05).
Conclusions: Estimation of serum vitamin D along with calcium, phosphorus and ALP may aid in improving the diagnosis and understanding the etiopathogenesis of lung cancer.
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Dr. Kiran Dahiya
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
Dr. Praveen Prashant
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
Dr. Rakesh Dhankhar
Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
Dr. Rajeev Atri
Department of Radiation Oncology, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
Dr., Gulshan Prakash
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
Kumud Dhankhar
MBBS, JSS Medical College, Mysore, Karnataka, India.
Ajay Momi
Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India.
