SALIVARY BIOMARKERS OF INFLAMMATION IN RESPONSE TO DENTAL MATERIALS IN ORAL PRECANCEROUS CONDITIONS IN AFGHAN POPULATION
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Keywords
Saliva, Biomarkers, Inflammation, Dental materials, Oral precancerous conditions, Cytokines.
Abstract
: Salivary biomarkers are non-invasive, cost-effective means to assess inflammatory responses and identify precancerous lesions in the oral cavity. The dental materials that are used may have an impact on local inflammation, altering the course of the disease and the state of the mucosa.
Objective: The primary purpose of the study was to measure the salivary biomarkers of inflammation (IL-1β, IL-6, and IL-8) generated in response to dental materials in patients with oral precancerous conditions in Afghan population.
Methods: A study was performed during the period September, 2024 to February, 2025 at National Stomatology Curative and Specialty Hospital, Kabul, Afghanistan. The study comprised 40 patients with oral precancerous lesions, who were randomly assigned to two groups: composite resin and amalgam.
Results: Significant increases in IL-1β, IL-6, and IL-8 were observed at 1-week post-treatment, especially in the composite resin group, followed by a gradual decline over two months.
Conclusion: Dental materials trigger transient inflammatory responses; salivary biomarkers can effectively monitor oral inflammation.
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Behzad Ali Khan
Mphil Oral Pathology Scholar, Khyber Medical University, Peshawar
Ali Mohammad Salamzai
Mphil Oral Pathology Scholar, Khyber Medical University, Peshawar
Fakhruddin Khalid
Mphil Oral Pathology Scholar, Khyber Medical University, Peshawar
Shabnam Mohmand
Kabul Medical University (Abu Ali Ibn e Sina)